A Study of CC-97540, CD19-targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

PHASE1CompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

May 21, 2020

Primary Completion Date

February 1, 2024

Study Completion Date

February 1, 2024

Conditions
Lymphoma Non-HodgkinAgressive LymphomaDiffuse-large B-cell Lymphoma (DLBCL)
Interventions
BIOLOGICAL

CC-97540

"Subjects will undergo leukapheresis to isolate peripheral blood mononuclear cells (PBMCs) to produce CC 97540.~During CC 97540 production, subjects may receive bridging chemotherapy for disease control. Upon successful generation of CC 97540 product, subjects will receive treatment with CC 97540 therapy.~Each cycle will include lymphodepleting chemotherapy followed by one dose of CC 97540 administered by intravenous (IV) injection."

Trial Locations (14)

10021

Local Institution - 001, New York

10065

Local Institution - 008, New York

28204

Local Institution - 010, Charlotte

30342

Local Institution - 004, Atlanta

68105

Nebraska Medicine Fred and Pamela Buffett Cancer Center, Omaha

84112

Huntsman Cancer Institute - University of Utah, Salt Lake City

97239

Oregon Health and Science University OHSU, Portland

35294-3300

Local Institution - 003, Birmingham

02114

Local Institution - 011, Boston

02215

Beth Israel Deaconess Medical Center, Boston

07601

Hackensack University Medical Center, Hackensack

T2N 2T9

Foothills Medical Centre - Tom Baker Cancer Centre, Calgary

V5Z 1M9

Vancouver General Hospital, Vancouver

L8V 1C3

Juravinski Cancer Centre, Hamilton

All Listed Sponsors
lead

Juno Therapeutics, a Subsidiary of Celgene

INDUSTRY

NCT04231747 - A Study of CC-97540, CD19-targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma | Biotech Hunter | Biotech Hunter