A Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B

PHASE2CompletedINTERVENTIONAL
Enrollment

281

Participants

Timeline

Start Date

July 5, 2020

Primary Completion Date

July 19, 2024

Study Completion Date

July 19, 2024

Conditions
Hepatitis B, Chronic
Interventions
DRUG

Nucleos(t)ide (NUC)

Nucleos(t)ide (NUC) will be administered orally

DRUG

CpAM (RO7049389)

CpAM (RO7049389) will be administered orally

DRUG

TLR7 (RO7020531)

TLR7 (RO7020531) will be administered orally

DRUG

siRNA (RO7445482)

siRNA (RO7445482) will be administered subcutaneously

DRUG

PEG-IFN

PEG-IFN will be administered subcutaneously

DRUG

PD-L1 LNA (RO7191863)

PD-L1 LNA (RO7191863) will be administered subcutaneously

Trial Locations (33)

500

Changhua Christian Hospital, Chang-hua

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

1010

Auckland Clinical Studies Limited, Auckland

1407

Tokuda Hospital Sofia, Sofia

1431

"University Multiprofile Hospital For Active Treatment Sveti Ivan Rilski EAD", Sofia

10002

National Taiwan University Hospital, Taipei

10330

HIVNAT, Bangkok

10700

Siriraj Hospital, Bangkok

36212

Hospital Alvaro Cunqueiro, Vigo

40447

China Medical University Hospital, Taichung

40705

Taichung Veterans General Hospital, Taichung

50200

Maharaj Nakorn Chiang Mai Hospital, Chiang Mai

92118

Hopital Beaujon, Clichy

100050

Beijing Friendship Hospital, Beijing

130021

The First Hospital of Jilin University, Changchun

200025

Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai

200040

Huashan Hospital, Fudan University, Shanghai

400006

Spitalul Clinic Judetean de Urgenta Cluj Napoca, Cluj-Napoca

510515

Nanfang Hospital, Southern Medical University, Guangzhou

610041

West China Hospital, Sichuan University, Chengdu

1700000

Hospital San Juan de Dios La Serena, La Serena

T2N 2T9

University of Calgary, Calgary

T6G 2S2

Uni of Alberta Hospital, Edmonton

M6H 3M1

Toronto Liver Centre, Toronto

Unknown

Queen Mary Hospital, Hong Kong

Middlemore Clinical Trials, Auckland

Seoul National University College of Medicine, Liver Research Institute, Seoul

200-704

Chuncheon Sacred Heart Hospital, Gangwon-Do

138-736

Asan Medical Center / Clinical Trial Center, Seoul

156-707

SMG-SNU Boramae Medical Center, Seoul

08035

Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona

00704

National Cheng Kung Univ Hosp, Tainan City

SE5 9RS

King College Hospital NHS Foundation Trust, London

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT04225715 - A Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B | Biotech Hunter | Biotech Hunter