Neurobiology of Bulimia Nervosa

During estradiol administration, 2mg of estradiol is given twice daily via oral capsule.

During progesterone administration, 200mg of progesterone is given twice daily via oral capsule.

Initial 3.75 mg intramuscular injection administered approximately Day 6 of menstrual cycle and then monthly thereafter for a total of 3 months.

Placebo is administered during the addback phase when participants are not taking active medication. Placebo is given so that medication administration occurs throughout the entire 8-week addback period in order to blind participants to when and for how long they are on the active medication.