Safety and Efficacy of a Switch to Doravirine/Islatravir in Participants With HIV-1 (MK-8591A-017)

PHASE3CompletedINTERVENTIONAL
Enrollment

672

Participants

Timeline

Start Date

February 18, 2020

Primary Completion Date

September 8, 2021

Study Completion Date

August 26, 2024

Conditions
HIV Infection
Interventions
DRUG

DOR/ISL

A FDC of 100 mg DOR/ 0.75 mg ISL taken in tablet form, orally, once daily

DRUG

ART

Baseline ART regimen will be administered as per approved label. ART medication will not be provided by the Sponsor; participants will provide their own ART medications. Allowed drug classes include nucleoside analog reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), integrase strand transferase inhibitors (InSTIs), fusion inhibitors, chemokine receptor 5 (CCR5) antagonists, post-attachment inhibitor, and pharmacokinetic (PK) boosters.

Trial Locations (78)

1211

Hopitaux Universitaires de Geneve HUG. ( Site 3304), Geneva

2010

Holdsworth House Medical Practice ( Site 2300), Sydney

3010

Inselspital Universitaetsspital Bern ( Site 3303), Bern

3053

Melbourne Sexual Health Centre ( Site 2305), Carlton

4029

Royal Brisbane and Womens Hospital- Infectious Diseases Unit ( Site 2309), Herston

4031

Universitaetsspital Basel ( Site 3302), Basel

6150

Fiona Stanley Hospital ( Site 2301), Murdoch

6903

Ospedale Regionale di Lugano Civico ( Site 3305), Lugano

7925

Desmond Tutu HIV Foundation Clinical Trial Unit ( Site 1414), Cape Town

8011

Christchurch Hospital ( Site 2303), Christchurch

8091

Universitaetsspital Zuerich ( Site 3300), Zurich

9007

Kantonsspital St. Gallen ( Site 3301), Sankt Gallen

9301

JOSHA Research ( Site 1406), Bloemfontein

19104

University of Pennsylvania ( Site 1038), Philadelphia

20007

Georgetown University Hospital ( Site 1018), Washington D.C.

20157

ASST Fatebenefratelli-Ospedale Sacco ( Site 2200), Milan

21079

Hopital Francois Mitterrand ( Site 2019), Dijon

27599

University of North Carolina at Chapel Hill ( Site 1042), Chapel Hill

28007

Hospital General Universitario Gregorio Maranon ( Site 1603), Madrid

28031

Hospital Universitario Infanta Leonor ( Site 1601), Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz ( Site 1602), Madrid

28046

Hospital Universitario La Paz ( Site 1604), Madrid

31059

CHU de Toulouse - Hopital Purpan ( Site 2004), Toulouse

31401

Chatham County Health Department ( Site 1043), Savannah

32803

Orlando Immunology Center ( Site 1007), Orlando

32806

Bliss Healthcare Services ( Site 1025), Orlando

33075

CHU de Bordeaux- Hopital Saint Andre ( Site 2015), Bordeaux

33407

Triple O Research Institute, P.A. ( Site 1026), West Palm Beach

34982

Midway Immunology and Research ( Site 1030), Ft. Pierce

44093

CHU Hotel Dieu Nantes ( Site 2020), Nantes

60657

Northstar Healthcare ( Site 1002), Chicago

64111

Kansas City CARE Health Center ( Site 1008), Kansas City

69317

Hopital de la Croix-Rousse ( Site 2027), Lyon

75010

A.P.H. Paris, Hopital Saint Louis ( Site 2014), Paris

75246

North Texas ID Consultants, PA ( Site 1003), Dallas

76031

CHU de Rouen ( Site 2005), Rouen

76104

Texas Centers for Infectious Disease Associates P.A. ( Site 1022), Fort Worth

77098

The Crofoot Research Center, Inc. ( Site 1005), Houston

77401

Saint Hope Foundation, Inc. ( Site 1037), Bellaire

80131

A.O.U. Universita degli Studi della Campania-Luigi Vanvitelli ( Site 2208), Napoli

105275

Federal Scientific Methodological AIDS Prevention and Control Center ( Site 1703), Moscow

Infectious Clinical Hospital #2 ( Site 1719), Moscow

190020

Saint Petersburg Center for Prophylactic of AIDS and Inf. Diseases ( Site 1701), Saint Petersburg

196645

FGU Republican Clinical Infectious Hospital of Roszdrav ( Site 1700), Saint Petersburg

420140

Republican Clinical Hospital of Infectious Diseases n. a. A.F.Agafonov ( Site 1707), Kazan'

620102

Regional Center for Prevent. and Control of AIDS and Inf. Diseases ( Site 1715), Yekaterinburg

650056

Kemerovo Regional Center for the Prevention and Control of AIDS ( Site 1713), Kemerovo

660049

Krasnoyarsk Regional Center for Prevention and Control of AIDS ( Site 1712), Krasnoyarsk

760032

Fundacion Valle del Lili ( Site 1201), Santiago de Cali

4781151

Hospital Dr. Hernan Henriquez Aravena ( Site 1305), Temuco

7560994

Clinica Arauco Salud ( Site 1300), Santiago

8330034

Centro de Investigacion Clinica UC CICUC ( Site 1303), Santiago

08844

ID Care ( Site 1023), Hillsborough

T2R 0X7

Southern Alberta HIV Clinic ( Site 1108), Calgary

V6Z 2C7

Vancouver ID Research and Care Centre Society ( Site 1100), Vancouver

L8L 2X2

Hamilton Health Sciences ( Site 1103), Hamilton

M5G 1K2

Maple Leaf Research ( Site 1112), Toronto

M5G 2N2

Toronto General Hospital - University Health Network ( Site 1105), Toronto

H2L 4E9

Clinique de Medecine Urbaine du Quartier Latin ( Site 1104), Montreal

H2L 4P9

Clinique Medicale L Actuel ( Site 1114), Montreal

00168

Policlinico Gemelli Instituto di Clinica Chirurgica ( Site 2206), Roma

460-0001

National Hospital Organization Nagoya Medical Center ( Site 2403), Nagoya

540-0006

National Hospital Organization Osaka National Hospital ( Site 2402), Osaka

113-8677

Tokyo Metropolitan Komagome Hospital ( Site 2406), Tokyo

160-0023

Tokyo Medical University Hospital ( Site 2404), Tokyo

162-8655

Center Hospital of the National Center for Global Health and Medicine ( Site 2401), Tokyo

50-220

EMC Instytut Medyczny SA Przychodnia przy ul. Lowieckiej we Wroclawiu ( Site 1500), Wroclaw

01-201

SP ZOZ Wojewodzki Szpital Zakazny ( Site 1505), Warsaw

50-136

Wroclawskie Centrum Zdrowia SP ZOZ ( Site 1507), Wroclaw

91-347

Wojewodzki Szpital Specjalistyczny im. dr. Wladyslawa Bieganskiego ( Site 1503), Lodz-Baluty

03202

Hospital General de Elche ( Site 1608), Elche

08916

Hospital Universitari Germans Trias i Pujol ( Site 1606), Badalona

08036

Hospital Clinic i Provincial ( Site 1600), Barcelona

BN2 1ES

Brighton and Sussex University Hospital NHS Trust ( Site 1908), Brighton

BS10 5NB

Southmead Hospital ( Site 1910), Bristol

NW3 2QG

Royal Free Hospital ( Site 1904), London

SE5 9RJ

Kings College Hospital NHS Foundation Trust ( Site 1907), London

M8 5RB

North Manchester General Hospital ( Site 1902), Manchester

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT04223778 - Safety and Efficacy of a Switch to Doravirine/Islatravir in Participants With HIV-1 (MK-8591A-017) | Biotech Hunter | Biotech Hunter