Dose-finding Study of Selective Serotonin Reuptake Inhibitors to Enhance Neuroplasticity

PHASE1/PHASE2WithdrawnINTERVENTIONAL
0
Timeline

Start Date

March 11, 2020

Primary Completion Date

February 9, 2021

Study Completion Date

February 9, 2021

Conditions
Stroke, Ischemic
Interventions
DRUG

Administration of SSRI escitalopram

Participants will be administered 5, 10 or 20mg of SRRI escitalopram prior to paired associative stimulation

BEHAVIORAL

Paired Associative stimulation

Participants will receive paired associative stimulation (transcranial magnetic stimulation and peripheral nerve stimulation) with an inter-stimulus interval length known to modulate corticospinal excitability.

DRUG

Administration of Placebo

Participants will be administered a placebo prior to paired associative stimulation

Trial Locations (1)

10605

Burke Neurological Institute, White Plains

All Listed Sponsors
lead

Burke Medical Research Institute

OTHER