800
Participants
Start Date
November 5, 2019
Primary Completion Date
November 30, 2026
Study Completion Date
November 30, 2032
Vincristine
1.5 mg/m2 (max dose 2 mg)
Carboplatin
750 mg/m2
Etoposide
175 mg/m2
Vindesine
3 mg/m2/day (max dose 6 mg)
Dacarbazine
200 mg/m2/day
Ifosfamide
1500 mg/m2/day
Doxorubicin
30 mg/m2/dose
Busulfan
\< 9kg: 1.0 mg/kg/dose 9 kg to \< 16 kg : 1.2 mg/kg/dose 16 kg to 23 kg : 1.1 mg/kg/dose \>23 kg to 34 kg: 0.95 mg/kg/dose \>34 kg: 0.8 mg/kg/dose Infusion IV over 2 hours Administration every 6 hours for a total of 16 doses
Melphalan
140 mg/m2/dose IV short infusion (15'), at least 24 h after the last busulfan dose
Thiotepa
300 mg/m2/day over 2 hours
Radiotherapy
21.6 Gy 21.6 Gy + boost de 14.4 Gy
Dinutuximab Beta
Patients \>12 kg are dosed based on the BSA: 10 mg/m\^2/day Patients ≤ 12 kg are dosed according to their body weight: 0.33 mg/kg/day
Cisplatin
80 mg/m2/24h
Temozolomide 100 MG
100 mg/m²/Day
Irinotecan
50 mg/m²/jour de J0 à J4
Cyclophosphamid
Cyclophosphamide has been demonstrated to have a cytostatic effect in many tumour types. The active metabolites of cyclophosphamide are alkylating agents which transfer alkyl groups to DNA during the process of cell division, thus preventing normal synthesis of DNA.
RECRUITING
University medical center Ljubljana, University Children's Hospital Ljubljana, Slovenia, Ljubljana
RECRUITING
Hôpital Universitaire des Enfants Reine Fabiola (ULB), Brussels
RECRUITING
Cliniques Universitaires Saint-Luc (UCL), Brussels
RECRUITING
University Hospitals Leuven, Leuven
RECRUITING
CHR Citadelle, Liège
RECRUITING
University Hospital Gent, Ghent
ACTIVE_NOT_RECRUITING
Universitair Medisch Centrum Groningen, Groningen
RECRUITING
"Children's General Hospital I AGHIA SOFIA", Athens
RECRUITING
"Children's General Hospital P. & A. KYRIAKOU", Athens
RECRUITING
charite universitatsmedizin Berlin, Berlin
RECRUITING
University Hospital Motol, Prague
RECRUITING
"MITERA Private, General, Obstetrics - Gynaecology, Paediatric Clinic S.A.", Athens
RECRUITING
Hospital Clínico Universitario de Santiago, Santiago de Compostela
RECRUITING
instituto Giannina Gaslini genova, Genova
RECRUITING
"IRCCS Istituto Giannina Gaslini", Genova
RECRUITING
Hospital Universitario Donostia, San Sebastián
RECRUITING
Policlino San matteo di Pavia, Pavia
RECRUITING
Hospital Universitario Infantil Niño Jesús, Madrid
RECRUITING
Hospital Universitario La Paz, Madrid
RECRUITING
Hospital Regional Universitario de Málaga, Málaga
RECRUITING
CHU Brest, Brest
RECRUITING
Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar
RECRUITING
CHU Bordeaux, Bordeaux
RECRUITING
IRCCS Burlo Garoflo oncoematologia, Trieste
RECRUITING
U.O.C oncoematologia pediatrica ospedale Donna Bambino, Verona
RECRUITING
Hospital Universitario Virgen del Rocío, Seville
RECRUITING
Azienda Policlinico di Modena, Modena
RECRUITING
Azienda ospedaliero universitaria di Parma, Parma
RECRUITING
U.O Pediatria, SS Oncoematologia pediatrica, Rimini
RECRUITING
Hospital Universitario Cruces, Cruces
RECRUITING
Azienda ospedaliero universtaria Anna Meyer, Florence
NOT_YET_RECRUITING
Uniklinik Köln, Klinik und Poliklinik für Kinder und Jugendmedizin, Cologne
RECRUITING
"University General Hospital of Thessaloniki AHEPA", Thessaloniki
RECRUITING
"General Hospital of Thessaloniki IPPOKRATIO", Thessaloniki
RECRUITING
A.O.U Policlinico di Bari, Bari
RECRUITING
University General Hospital of Heraklion (UnGHH), Heraklion
RECRUITING
CHU d'AMIENS, Amiens
RECRUITING
Gustave Roussy, Villejuif
RECRUITING
policlinico rodolico San marco, Catania
RECRUITING
Spedali civili Ospedale Dei Bambini Oncoematologia pediatrica e TMO, Brescia
RECRUITING
Sydney children Hospital, Sydney
ACTIVE_NOT_RECRUITING
Australian and New Zealand Children's Hematology/oncology Group, Sydney
RECRUITING
sydney children Hospital, Sydney
RECRUITING
Children's Cancer Centre, Monash Children's Hospital, Clayton
SUSPENDED
Oncology/Haematology Department, Perth Children's Hospital, Nedlands
RECRUITING
Children's Cancer & Haematology Services, John Hunter Children's Hospital, New Lambton Heights
SUSPENDED
Cancer Centre for Children, The Children's Hospital, Westmead
RECRUITING
Medical University Graz, Graz
RECRUITING
Landeskrankenhaus-Universitätsklinikum Innsbruck, Innsbruck
RECRUITING
Kepler Universitatsklinikum Linz, Linz
RECRUITING
Universitastsklinikum Salzburg, Salzburg
NOT_YET_RECRUITING
Kuopio University Hospital, Kuopio
NOT_YET_RECRUITING
Oulu University Hospital, Oulu
NOT_YET_RECRUITING
Tampere University Hospital, Tampere
NOT_YET_RECRUITING
Turku University Hospital, Turku
RECRUITING
CHU angers, Angers
RECRUITING
CHU-Pôle Médico-Chirurgical de l'Enfant et l'Adolescant, Besançon
RECRUITING
Groupe Hospitalier Pellegrin - Chu - Bordeaux, Bordeaux
RECRUITING
CHU Brest - Hôpital du Morvan, Brest
ACTIVE_NOT_RECRUITING
Centre François Baclesse, Caen
RECRUITING
CHU de Caen, Caen
RECRUITING
CHU Estaing, Clermont-Ferrand
ACTIVE_NOT_RECRUITING
Centre Georges-François Leclerc, Dijon
RECRUITING
Hopital d'enfants Marechal de lattre, Dijon
RECRUITING
Hôpital Couple-Enfant CHU de Grenoble, Grenoble
RECRUITING
Chu de La Reunion - St Denis, La Réunion
RECRUITING
centre Oscar lambert, Lille
RECRUITING
Hôpital de la Mère et de l'Enfant - CHU Limoges, Limoges
RECRUITING
Centre Léon Berard, Lyon
RECRUITING
hopital la Timone, Marseille
RECRUITING
CHRU Nancy-Hôpital Brabois Enfant, Nancy
ACTIVE_NOT_RECRUITING
Institut de cancérologie de Loraine, Nancy
ACTIVE_NOT_RECRUITING
Centre Antoine Lacassagne, Nice
RECRUITING
CHU Nice-Hôpital d'Archet, Nice
RECRUITING
Hôpital Armand Trousseau, Paris
RECRUITING
institut Curie, Paris
RECRUITING
CHU Poitiers, Poitiers
RECRUITING
Hôpital Américain -CHU Reims, Reims
ACTIVE_NOT_RECRUITING
Centre Eugène Marquis, Rennes
RECRUITING
CHU Rennes, Rennes
RECRUITING
Hôpital des Enfants - CHU Rouen, Rouen
RECRUITING
CHU Saint Etienne, Saint-Etienne
ACTIVE_NOT_RECRUITING
Institut de cancérologie de l'Ouest - Sité René Gauducheau, Saint-Herblain
RECRUITING
CHU Haute Pierre, Strasbourg
ACTIVE_NOT_RECRUITING
Institut de Cancérologie Strasbourg, Strasbourg
RECRUITING
Hopital des enfants-CHU Toulouse, Toulouse
ACTIVE_NOT_RECRUITING
IUCT Oncopole, Toulouse
RECRUITING
CHU Tours Hôpital Clocheville, Tours
RECRUITING
"Children's General Hospital AGHIA SOFIA", Athens
RECRUITING
RAMBAM Medical Center, Haifa
RECRUITING
Haukeland University Hospital, Haukeland
NOT_YET_RECRUITING
University Hospital Northern Norway, Tromsoe, Tromsø
NOT_YET_RECRUITING
St Olavs Hospital,, Trondheim
RECRUITING
Hospital Universitario Politécnico de La FE, Valencia
NOT_YET_RECRUITING
Sahlgrenska University Hospital, Gothenburg
NOT_YET_RECRUITING
Linköping University Hospital, Linköping
NOT_YET_RECRUITING
Skåne University Hospital, Lund
NOT_YET_RECRUITING
Karolinska University Hospital, Stockholm, Stockholm
NOT_YET_RECRUITING
Norrland University Hospital, Umeå
NOT_YET_RECRUITING
Uppsala University Hospital, Uppsala
RECRUITING
Royal Aberdeen Children's Hospital, Aberdeen
NOT_YET_RECRUITING
Royal Belfast Hospital for Sick Children, Belfast
RECRUITING
Addenbrookes Hospital, Cambridge, Cambridge
NOT_YET_RECRUITING
Noah's Ark Children's Hospital for Wales - Cardiff, Cardiff
NOT_YET_RECRUITING
Royal Hospital for Sick Children - Edinburgh, Edinburgh
RECRUITING
Leeds General Infirmary, Leeds
RECRUITING
Alder Hey Children's Hospital - Liverpool, Liverpool
RECRUITING
Great Ormond Street Hospital - London, London
RECRUITING
Royal Manchester Children's Hospital, Manchester
RECRUITING
Royal Victoria Infirmary, Newcastle, Newcastle
RECRUITING
Nottingham Children's Hospital, Nottingham
RECRUITING
Southampton General Hospital, Southampton
RECRUITING
St Anna'S Children Hospital, Vienna
NOT_YET_RECRUITING
Klinika dětské onkologie FN Brno, Brno
RECRUITING
Aarhus University Hospital, Aarhus
RECRUITING
Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen
RECRUITING
The Hans Christian Andersen Children's Hospital, University of Southern Denmark, Odense
NOT_YET_RECRUITING
New Children's Hospital, Helsinki University Hospital, Helsinki and Uusimaa Hospital District, Helsinki
NOT_YET_RECRUITING
Vilnius University Hospital Santaros Klinikos, Vilnius
NOT_YET_RECRUITING
National Cancer Institute, Vilnius
RECRUITING
Princess Maxima center, Utrecht
RECRUITING
Oslo University Hospital, Oslo
NOT_YET_RECRUITING
Children's University Hospital Banská Bystrica, Banská Bystrica
NOT_YET_RECRUITING
NÚDCH- National Institute of Children's Diseases,, Bratislava
NOT_YET_RECRUITING
Children's University Hospital Košice, Košice
RECRUITING
Hospital Universitario Son Espases, Balea
RECRUITING
Hospital Universitario Vall D´Hebron, Barcelona
RECRUITING
Kantonsspital Aarau AG Klinik für Kinder und Jugendliche, Aarau
RECRUITING
Universitäts-Kinderspital beider Basel (UKBB), Basel
RECRUITING
Ospedale San Giovanni Pediatria, Emato-oncologia pediatrica, Bellinzona
RECRUITING
Inselspital, Universitätsklinik für Kinderheilkunde, Bern
RECRUITING
HUG Hôpitaux Universitaires de Genève Unité d'Hémato-Oncologie Pédiatrique, Geneva
RECRUITING
CHUV - Centre Hospitalier Universitaire Vaudois, Lausanne
RECRUITING
Luzerner Kantonsspital, Kinderspital pädiatrische Hämatologie/Onkologie, Lucerne
RECRUITING
Ostschweizer Kinderspital Hämatologie/Onkologie Claudiusstrasse 6, Sankt Gallen
RECRUITING
Division of Pediatric Oncology Universitäts-Kinderspital Zürich, Zurich
RECRUITING
Birmingham children's Hospital, Birmingham
ACTIVE_NOT_RECRUITING
University Hospitals Birmingham Queen Elisabeth Hospital(UHB), Birmingham
RECRUITING
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol
RECRUITING
Royal Hospital for Children Glasgow, Glasgow
RECRUITING
Sheffield Children's Hospital, Sheffield
RECRUITING
Royal Marsden Hospital, Sutton
Gustave Roussy, Cancer Campus, Grand Paris
OTHER