Study of Intratumoral (IT) Ulevostinag (MK-1454) in Combination With Intravenous (IV) Pembrolizumab (MK-3475) Compared to IV Pembrolizumab Alone as the First Line Treatment of Metastatic or Unresectable, Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC) (MK-1454-002)

PHASE2CompletedINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

March 4, 2020

Primary Completion Date

September 30, 2022

Study Completion Date

September 30, 2022

Conditions
Head and Neck Squamous Cell Carcinoma (HNSCC)
Interventions
DRUG

Ulevostinag

IT injection

BIOLOGICAL

Pembrolizumab

IV infusion

Trial Locations (34)

1090

Allgemeines Krankenhaus der Stadt Wien ( Site 0049), Vienna/Wien

2050

Chris OBrien Lifehouse ( Site 0040), Camperdown

3168

Monash Health-Monash Medical Centre ( Site 0041), Clayton

4010

Ordensklinikum Linz Gmbh - Barmherzige Schwestern ( Site 0051), Linz

5020

SCRI-CCCIT GesmbH ( Site 0050), Salzburg

5021

Haukeland Universitetssykehus, Klinisk forskningspost voksne ( Site 0086), Bergen

5112

Calvary Central Districts Hospital ( Site 0042), Elizabeth Vale

28034

Hospital Universitario Ramon y Cajal ( Site 0115), Madrid

29010

Hospital Universitario Virgen de la Victoria ( Site 0114), Málaga

31059

IUCT - Oncopole ( Site 0069), Toulouse

48202

Henry Ford Hospital ( Site 0012), Detroit

57104

Sanford Cancer Center Oncology Clinic ( Site 0014), Sioux Falls

59000

Centre Oscar Lambret ( Site 0071), Lille

63110

Washington University ( Site 0021), St Louis

69373

Centre Leon Berard ( Site 0072), Lyon

84112

Huntsman Cancer Institute ( Site 0004), Salt Lake City

90095

UCLA Hematology & Oncology ( Site 0005), Los Angeles

94158

University of California at San Francisco ( Site 0006), San Francisco

94800

Gustave Roussy ( Site 0068), Villejuif

3109601

Rambam Medical Center ( Site 0077), Haifa

5265601

Chaim Sheba Medical Center ( Site 0076), Ramat Gan

9112001

Hadassah Medical Center. Ein Kerem ( Site 0078), Jerusalem

60336-232

Centro Regional Integrado de Oncologia ( Site 0062), Fortaleza

98700-000

Hospital de Caridade de Ijui ( Site 0061), Ijuí

01246-000

Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0058), São Paulo

01321-001

Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 0064), São Paulo

06189

Centre Antoine Lacassagne ( Site 0070), Nice

0379

Oslo Universitetssykehus Radiumhospitalet ( Site 0085), Oslo

03722

Severance Hospital ( Site 0103), Seoul

05505

Asan Medical Center ( Site 0104), Seoul

08035

H.U. Vall de Hebron ( Site 0112), Barcelona

08036

Hospital Clinico de Barcelona ( Site 0116), Barcelona

SW3 6JJ

Royal Marsden NHS Foundation Trust ( Site 0031), London

SM2 5PT

Royal Marsden Hospital Sutton-Surrey ( Site 0032), Sutton

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT04220866 - Study of Intratumoral (IT) Ulevostinag (MK-1454) in Combination With Intravenous (IV) Pembrolizumab (MK-3475) Compared to IV Pembrolizumab Alone as the First Line Treatment of Metastatic or Unresectable, Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC) (MK-1454-002) | Biotech Hunter | Biotech Hunter