Safety, Tolerance and Pharmacokinetics Study of Compound Edaravone Injection

PHASE1CompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

June 5, 2019

Primary Completion Date

August 16, 2019

Study Completion Date

August 16, 2019

Conditions
Pharmacokinetics
Interventions
DRUG

Group 1: Compound Edaravone/Placebo Injection

Compound Edaravone 30mg-600mg (containing edaravone 30 mg and 2-aminoethanesulfonic acid 600 mg) / placebo single intravenous infusion for 30min

DRUG

Group 2: Compound Edaravone/Placebo Injection

Compound Edaravone 60mg-1200mg (containing edaravone 60 mg and 2-aminoethanesulfonic acid 1200 mg) / placebo single intravenous infusion for 30min

DRUG

Group 3: Compound Edaravone/Placebo Injection

Compound Edaravone 90mg-1800mg (containing edaravone 90 mg and 2-aminoethanesulfonic acid 1800 mg) / placebo single intravenous infusion for 30min

DRUG

Group 4: Compound Edaravone/Placebo Injection

Compound Edaravone 120mg-2400mg (containing edaravone 120 mg and 2-aminoethanesulfonic acid 2400 mg) / placebo single intravenous infusion for 30min

DRUG

Group 5: Compound Edaravone/Placebo Injection

Maximum tolerated dose of drug / placebo for a single intravenous infusion for 30 minutes three times a day at an interval of 8 h until the last dose on the morning of Day 3, after which the sequential test drug 30 mg-600 mg / placebo will be administered daily from Day 3 night Intravenous infusion, 30 minutes at 12-hour intervals until morning on Day 7

Trial Locations (1)

100050

Beijing Tiantan Hospital, Capital Medical University, Beijing

All Listed Sponsors
lead

Nanjing Yoko Biomedical Co., Ltd.

INDUSTRY

NCT04219865 - Safety, Tolerance and Pharmacokinetics Study of Compound Edaravone Injection | Biotech Hunter | Biotech Hunter