Single-dose/Multiple-doses Incremental Intravenous Injection of SY-005 (Recombinant Human Annexin A5)in Healthy Subjects

PHASE1CompletedINTERVENTIONAL
Enrollment

96

Participants

Timeline

Start Date

April 26, 2019

Primary Completion Date

October 5, 2019

Study Completion Date

August 19, 2020

Conditions
Sepsis
Interventions
DRUG

SY-005

This single-dose group will be initiated in healthy subjects at a 0.75mg dose that is the maximum recommended starting dose(MRSD). Doses will be escalated in subsequent dosing process, after appropriate review of safety data. The subsequent planned doses are2.5mg, 5mg, 10mg, 15mg, 20mg successively. The dose of multiple-doses groups are depending on the results of single-dose groups.

Trial Locations (1)

210029

Jiangsu Province Hospital, Nanjing

All Listed Sponsors
lead

Suzhou Yabao Pharmaceutical R&D Co., Ltd.

INDUSTRY

NCT04217629 - Single-dose/Multiple-doses Incremental Intravenous Injection of SY-005 (Recombinant Human Annexin A5)in Healthy Subjects | Biotech Hunter | Biotech Hunter