Testing the Addition of an Anti-cancer Drug, Berzosertib (M6620, VX-970), to the Usual Treatments (Carboplatin and Gemcitabine) and to Pembrolizumab for Patients With Advanced Squamous Cell Non-small Cell Lung Cancer

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

April 14, 2021

Primary Completion Date

March 31, 2024

Study Completion Date

April 12, 2025

Conditions
Lung Non-Small Cell Squamous CarcinomaStage IV Lung Cancer AJCC v8
Interventions
DRUG

Berzosertib

Given IV

PROCEDURE

Biospecimen Collection

Correlative studies

DRUG

Carboplatin

Given IV

PROCEDURE

Computed Tomography

Undergo CT

DRUG

Gemcitabine Hydrochloride

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

BIOLOGICAL

Pembrolizumab

Given IV

Trial Locations (34)

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

27012

Wake Forest University at Clemmons, Clemmons

27157

Wake Forest University Health Sciences, Winston-Salem

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33180

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64108

University Health Truman Medical Center, Kansas City

64116

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

66044

Lawrence Memorial Hospital, Lawrence

66061

Olathe Health Cancer Center, Olathe

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Clinical Research Center, Fairway

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66211

University of Kansas Hospital-Indian Creek Campus, Overland Park

66606

University of Kansas Health System Saint Francis Campus, Topeka

66762

Ascension Via Christi - Pittsburg, Pittsburg

67401

Salina Regional Health Center, Salina

67601

HaysMed, Hays

90020

Keck Medicine of USC Koreatown, Los Angeles

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

92663

USC Norris Oncology/Hematology-Newport Beach, Newport Beach

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH