Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

168

Participants

Timeline

Start Date

April 9, 2020

Primary Completion Date

December 30, 2025

Study Completion Date

December 30, 2025

Conditions
Endometrial Endometrioid AdenocarcinomaStage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8Stage II Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8
Interventions
PROCEDURE

Biospecimen Collection

Undergo collection of blood

RADIATION

Brachytherapy

Undergo vaginal brachytherapy

PROCEDURE

Computed Tomography

Undergo CT

RADIATION

External Beam Radiation Therapy

Undergo EBRT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

BIOLOGICAL

Pembrolizumab

Given IV

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

PROCEDURE

X-Ray Imaging

Undergo x-rays

Trial Locations (280)

10011

Mount Sinai Chelsea, New York

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10019

Mount Sinai West, New York

10029

Mount Sinai Hospital, New York

10065

Memorial Sloan Kettering Cancer Center, New York

NYP/Weill Cornell Medical Center, New York

10604

Memorial Sloan Kettering Westchester, Harrison

11040

Long Island Jewish Medical Center, New Hyde Park

11042

Northwell Health/Center for Advanced Medicine, Lake Success

11215

New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn

11355

The New York Hospital Medical Center of Queens, Flushing

11501

NYU Langone Hospital - Long Island, Mineola

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

11794

Stony Brook University Medical Center, Stony Brook

12208

Women's Cancer Care Associates LLC, Albany

14620

Highland Hospital, Rochester

14642

University of Rochester, Rochester

15213

UPMC-Magee Womens Hospital, Pittsburgh

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

17015

Carlisle Regional Cancer Center, Carlisle

17042

Sechler Family Cancer Center, Lebanon

17050

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

17109

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17325

Adams Cancer Center, Gettysburg

17403

WellSpan Health-York Cancer Center, York

WellSpan Health-York Hospital, York

17522

Ephrata Cancer Center, Ephrata

17601

Lancaster General Ann B Barshinger Cancer Institute, Lancaster

17602

Lancaster General Hospital, Lancaster

19090

Asplundh Cancer Pavilion, Willow Grove

19096

Lankenau Medical Center, Wynnewood

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

Pennsylvania Hospital, Philadelphia

Thomas Jefferson University Hospital, Philadelphia

19301

Paoli Memorial Hospital, Paoli

19380

Chester County Hospital, West Chester

21215

Sinai Hospital of Baltimore, Baltimore

23235

VCU Massey Cancer Center at Stony Point, Richmond

23298

VCU Massey Comprehensive Cancer Center, Richmond

24033

Carilion Roanoke Memorial Hospital, Roanoke

25304

West Virginia University Charleston Division, Charleston

27403

Cone Health Cancer Center, Greensboro

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27607

Duke Women's Cancer Care Raleigh, Raleigh

27609

Duke Cancer Center Raleigh, Raleigh

27710

Duke University Medical Center, Durham

29601

Saint Francis Hospital, Greenville

29605

Prisma Health Cancer Institute - Faris, Greenville

29607

Saint Francis Cancer Center, Greenville

29910

Saint Joseph's/Candler - Bluffton Campus, Bluffton

30041

Northside Hospital-Forsyth, Cumming

30060

Wellstar Kennestone Hospital, Marietta

30265

CTCA at Southeastern Regional Medical Center, Newnan

30342

Northside Hospital, Atlanta

31404

Memorial Health University Medical Center, Savannah

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

33905

GenesisCare USA - FGO, Fort Myers

Regional Cancer Center-Lee Memorial Health System, Fort Myers

35233

University of Alabama at Birmingham Cancer Center, Birmingham

40207

Baptist Health Louisville, Louisville

40503

Baptist Health Lexington, Lexington

41017

Saint Elizabeth Healthcare Edgewood, Edgewood

43016

Dublin Methodist Hospital, Dublin

43054

Mount Carmel New Albany Surgical Hospital, New Albany

43081

Saint Ann's Hospital, Westerville

43123

Mount Carmel Grove City Hospital, Grove City

43210

Ohio State University Comprehensive Cancer Center, Columbus

43213

Mount Carmel East Hospital, Columbus

43214

Riverside Methodist Hospital, Columbus

43219

The Mark H Zangmeister Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43701

Genesis Healthcare System Cancer Care Center, Zanesville

44024

Geauga Hospital, Chardon

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44109

MetroHealth Medical Center, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44145

UH Seidman Cancer Center at Saint John Medical Center, Westlake

UHHS-Westlake Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44281

University Hospitals Sharon Health Center, Wadsworth

44710

Aultman Health Foundation, Canton

45005

Dayton Physicians LLC-Atrium, Franklin

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45415

Dayton Physician LLC - Englewood, Dayton

Miami Valley Hospital North, Dayton

45459

Dayton Physicians LLC-Miami Valley South, Centerville

Miami Valley Hospital South, Centerville

46260

Ascension Saint Vincent Indianapolis Hospital, Indianapolis

48073

Corewell Health William Beaumont University Hospital, Royal Oak

48085

Corewell Health Beaumont Troy Hospital, Troy

48124

Corewell Health Dearborn Hospital, Dearborn

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48334

Weisberg Cancer Treatment Center, Farmington Hills

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53045

Ascension Southeast Wisconsin Hospital - Elmbrook Campus, Brookfield

53097

Ascension Columbia Saint Mary's Hospital Ozaukee, Mequon

53132

Ascension Saint Francis - Reiman Cancer Center, Franklin

Ascension Southeast Wisconsin Hospital - Franklin, Franklin

53210

Ascension Southeast Wisconsin Hospital - Saint Joseph Campus, Milwaukee

53211

Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee

53215

Ascension Saint Francis Hospital, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

Ascension Medical Group Southeast Wisconsin - Mayfair Road, Wauwatosa

53405

Ascension All Saints Hospital, Racine

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Medical Center - Minocqua, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Minnesota Oncology - Burnsville, Burnsville

55362

Monticello Cancer Center, Monticello

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

56201

Rice Memorial Hospital, Willmar

56303

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

57105

Avera Cancer Institute, Sioux Falls

57701

Rapid City Regional Hospital, Rapid City

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60099

Midwestern Regional Medical Center, Zion

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60153

Loyola University Medical Center, Maywood

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

University of Chicago Medicine-Orland Park, Orland Park

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

Rush MD Anderson Cancer Center, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

62269

Cancer Care Center of O'Fallon, O'Fallon

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

62801

Centralia Oncology Clinic, Centralia

63080

Missouri Baptist Sullivan Hospital, Sullivan

63110

Washington University School of Medicine, St Louis

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

68114

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC, Omaha

Nebraska Methodist Hospital, Omaha

Oncology Associates PC, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

70006

East Jefferson General Hospital, Metairie

70112

Louisiana State University Health Science Center, New Orleans

University Medical Center New Orleans, New Orleans

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

75235

Parkland Memorial Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

Ben Taub General Hospital, Houston

Houston Methodist Hospital, Houston

M D Anderson Cancer Center, Houston

77070

Methodist Willowbrook Hospital, Houston

77079

MD Anderson West Houston, Houston

77094

Houston Methodist West Hospital, Houston

77384

MD Anderson in The Woodlands, Conroe

77385

Houston Methodist The Woodlands Hospital, The Woodlands

77478

MD Anderson in Sugar Land, Sugar Land

77479

Houston Methodist Sugar Land Hospital, Sugar Land

77573

MD Anderson League City, League City

80045

UCHealth University of Colorado Hospital, Aurora

80122

AdventHealth Littleton, Littleton

80129

UCHealth Highlands Ranch Hospital, Highlands Ranch

80138

AdventHealth Parker, Parker

80210

AdventHealth Porter, Denver

80907

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

80909

UCHealth Memorial Hospital Central, Colorado Springs

80920

Memorial Hospital North, Colorado Springs

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Luke's Cancer Institute - Nampa, Nampa

83712

Saint Luke's Cancer Institute - Boise, Boise

84025

Farmington Health Center, Farmington

84106

University of Utah Sugarhouse Health Center, Salt Lake City

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

87106

University of New Mexico Cancer Center, Albuquerque

89106

Women's Cancer Center of Nevada, Las Vegas

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

90095

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles

92093

UC San Diego Moores Cancer Center, La Jolla

93611

Community Cancer Institute, Clovis

University Oncology Associates, Clovis

94158

UCSF Medical Center-Mission Bay, San Francisco

94520

John Muir Medical Center-Concord, Concord

94598

John Muir Medical Center-Walnut Creek, Walnut Creek

96701

Hawaii Cancer Care - Westridge, ‘Aiea

Pali Momi Medical Center, ‘Aiea

96766

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Queen's Cancer Cenrer - POB I, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

Hawaii Cancer Care Inc-Liliha, Honolulu

Queen's Cancer Center - Kuakini, Honolulu

The Cancer Center of Hawaii-Liliha, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97030

Legacy Mount Hood Medical Center, Gresham

97062

Legacy Meridian Park Hospital, Tualatin

97132

Providence Newberg Medical Center, Newberg

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

98686

Legacy Salmon Creek Hospital, Vancouver

06810

Danbury Hospital, Danbury

06418

Smilow Cancer Hospital-Derby Care Center, Derby

06824

Smilow Cancer Hospital Care Center-Fairfield, Fairfield

06033

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury

06830

Smilow Cancer Hospital Care Center at Greenwich, Greenwich

06437

Smilow Cancer Hospital Care Center - Guilford, Guilford

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06510

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

Yale University, New Haven

06473

Yale-New Haven Hospital North Haven Medical Center, North Haven

06856

Norwalk Hospital, Norwalk

06477

Smilow Cancer Hospital-Orange Care Center, Orange

06790

Smilow Cancer Hospital-Torrington Care Center, Torrington

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06708

Smilow Cancer Hospital-Waterbury Care Center, Waterbury

06385

Smilow Cancer Hospital Care Center - Waterford, Waterford

04530

MaineHealth Coastal Cancer Treatment Center, Bath

04005

MaineHealth Maine Medical Center - Biddeford, Biddeford

04102

MaineHealth Maine Medical Center - Portland, Portland

04073

MaineHealth Cancer Care and IV Therapy - Sanford, Sanford

04074

MaineHealth Maine Medical Center- Scarborough, Scarborough

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

08103

Cooper Hospital University Medical Center, Camden

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

08057

Virtua Samson Cancer Center, Moorestown

07753

Jersey Shore Medical Center, Neptune City

08043

Virtua Voorhees, Voorhees Township

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

02905

Women and Infants Hospital, Providence

02891

Smilow Cancer Hospital Care Center - Westerly, Westerly

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

00959-5060

Cancer Center-Metro Medical Center Bayamon, Bayamón

00674

Doctors Cancer Center, Manatí

00917

San Juan Community Oncology Group, San Juan

00927

Centro Comprensivo de Cancer de UPR, San Juan

00936

San Juan City Hospital, San Juan

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH

NCT04214067 - Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer | Biotech Hunter | Biotech Hunter