NK Cells Infusions With Irinotecan, Temozolomide, and Dinutuximab

NK cells dose 1x 108 cells/ kg on day 8 of each cycle

Temozolomide 100mg/m2/dose PO or IV daily on Days 1-5; if given orally, must be at least one hour prior to Irinotecan. For patients whose body surface area is \<0.5m2, temozolomide dosing is based on body weight in (kg), at a dose of 3.3 mg/kg/dose.

Irinotecan 50mg/m2/dose IV daily on Days 1-5

Dinutuximab 17.5mg/m2/dose IV daily on Days 2-5

Sargramostim 250mcg/m2/dose subcutaneous daily on Days 6-12