A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

291

Participants

Timeline

Start Date

February 11, 2020

Primary Completion Date

May 22, 2023

Study Completion Date

February 28, 2026

Conditions
Medullary Thyroid Cancer
Interventions
DRUG

Selpercatinib

Administered orally

DRUG

Cabozantinib

Administered orally

DRUG

Vandetanib

Administered orally

Trial Locations (143)

2065

Royal North Shore Hospital, St Leonards

3004

The Alfred Hospital, Melbourne

3050

Peter MacCallum Cancer Centre, Melbourne

3080

Seoul National University Hospital, Seoul

3722

Severance Hospital, Yonsei University Health System, Seoul

4000

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman, Liège

6009

Sir Charles Gairdner Hospital, Perth

6351

Samsung Medical Center, Seoul

8035

Hospital Universitari Vall d'Hebron, Barcelona

8907

Instituto Catalan de Oncologia - Hospital Duran i Reynals, L'Hospitalet de Llobregat

10017

Memorial Sloan Kettering Cancer Center, New York

10117

Charité Universitaetsmedizin Berlin - Campus Mitte, Berlin

10126

Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin

10408

National Cancer Center, Goyang-si

13620

Seoul National University Bundang Hospital, Seongnam

13915

Assistance Publique Hôpitaux de Marseille - Hôpital Nord, Marseille

14076

Centre François Baclesse, Caen

17007

Institut Català d'Oncologia (ICO) - Girona, Girona

19104

University of Pennsylvania Hospital, Philadelphia

19114

Thomas Jefferson University, Philadelphia

20122

Istituto Auxologico Italiano, Milan

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20251

Hämato-Onkologie Hamburg, Prof. Laack und Partner, Hamburg

21079

Centre Georges François Leclerc, Dijon

28009

Hospital General Universitario Gregorio Marañon, Madrid

28027

Clinica Universidad de Navarra, Madrid

28034

Hospital Universitario Ramón y Cajal, Madrid

28040

Hospital Clinico San Carlos, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28644

Chungbuk National University Hospital, Jungbuk

29010

Hospital Universitario Virgen de la Victoria, Málaga

30322

Emory University, Atlanta

30625

Medizinische Hochschule Hannover, Hanover

31008

Clinica Universidad de Navarra, Pamplona

31059

Institut Claudius Regaud, Toulouse

33076

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux

35128

Istituto Oncologico Veneto IRCCS, Padua

35249

University of Alabama at Birmingham, Birmingham

39120

Otto-von-Guericke-Universität Magdeburg, Magdeburg

43210

The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center, Columbus

45122

Universitaetsklinikum Essen, Essen

45219

University of Cincinnati Medical Center, Cincinnati

48109

University of Michigan, Ann Arbor

49933

Centre Hospitalier Universitaire d'Angers, Angers

50009

Hospital Universitario Miguel Servet, Zaragoza

53100

Ospedale Le Scotte, Siena

53792

University of Wisconsin Hospitals and Clinics, Madison

55131

Universitätsmedizin Johannes Gutenberg Universität Mainz, Mainz

56124

Azienda Ospedaliera Universitaria Pisana, Pisa

59037

Hopital Claude Huriez - CHU de Lille, Lille

60637

University of Chicago Medical Center, Chicago

63011

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne, Clermont-Ferrand

67065

Centre Paul Strauss, Strasbourg

69008

Centre Leon Berard, Lyon

75013

Pitie Salpetriere University Hospital, Paris

77030

University of Texas MD Anderson Cancer Center, Houston

80131

University of Naples Federico II, Napoli

81337

Klinikum der Universität München Großhadern, München

90095

UCLA Hematology/Oncology - Westwood (Building 100), Los Angeles

90502

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance

94800

Gustave Roussy, Villejuif

95124

Azienda Ospedaliera Garibaldi, Catania

95817

University of California Davis (UC Davis) Comprehensive Cancer Center, Sacramento

97080

Klinikum der Universität München Großhadern, Würzburg

100730

Beijing Tongren Hospital affiliated to Capital Medical University, Beijing

115478

"Fed State Budgetary Inst N.N. Blokhin Med Center of Oncology MHRF", Moscow

117292

Endocrinology Research Center of Rosmedtechnologies, Moscow

132000

Jilin Cancer Hospital, Changchun

150081

Harbin Medical University Cancer Hospital, Harbin

160012

Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh

190020

Saint Petersburg State University, Saint Petersburg

198255

Saint-Petersburg City Clinical Oncology Dispensary, Saint Petersburg

200032

Fudan University Shanghai Cancer Center, Shanghai

210000

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing

230071

Anhui Provincial Hospital, Hefei

249036

A. Tsyb Medical Radiological Research Center - branch of the National Medical Research Radiological, Obninsk

250013

Jinan Central Hospital, Jinan

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310014

Zhejiang Provincial People's Hospital, Hangzhou

310016

Sir Run Run Shaw Hospital, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

350005

The First Affiliated Hospital Of Fujian Medical University, Fuzhou

400030

Chongqing University Cancer Hospital, Chongqing

410013

Hunan Cancer Hospital, Changsha

411001

Grant Medical Foundation - Ruby Hall Clinic, Pune

411004

Deenanath Mangeshkar Hospital & Research Centre, Pune

422001

HCG Manavata Cancer Centre, Nashik

450008

Henan Cancer Hospital, Zhengzhou

454048

Clinic Evimed, Chelyabinsk

510060

Sun Yat-Sen University Cancer Centre, Guangzhou

610041

West China Hospital, Sichuan University, Chengdu

650032

First Affiliated Hospital of Kunming Medical University, Kunming

695011

Regional Cancer Centre - Thiruvananthapuram, Thiruvananthapuram

700054

Apollo Gleneagles Hospitals Kolkata, Kolkata

730050

Gansu Cancer Hospital, Lanzhou

4941492

Rabin Medical Center, Petah Tikva

5265601

Sheba Medical Center, Ramat Gan

9112001

Hadassah Medical Center, Jerusalem

14784400

Fundação Pio XII - Hospital de Câncer de Barretos, Barretos

91010-0269

City of Hope National Medical Center, Duarte

02114

Massachusetts General Hospital, Boston

30380-680

Oncocentro, Belo Horizonte

86015-520

Hospital de Cancer de Londrina, Londrina

90035-903

Hospital de Clinicas de Porto Alegre, Porto Alegre

13060-904

Centro de Pesquisa Sao Lucas, Campinas

14051-140

Hospital de Clínicas de Ribeirão Preto, Ribeirão Preto

01308-060

Hospital Sírio Libanês, São Paulo

04543-000

Instituto D'Or de Pesquisa e Ensino (IDOR), São Paulo

20230-130

Instituto Nacional de Câncer - INCA, Rio de Janeiro

22250-905

Grupo Oncoclínicas Botafogo, Rio de Janeiro

22775-001

Grupo COI - Clínicas Oncológicas Integradas, Rio de Janeiro

01246-000

Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo

01452-000

Centro Paulista de Oncologia Clínica, São Paulo

M5G 2M9

Princess Margaret Cancer Centre, Toronto

625 00

Fakultní nemocnice Brno Bohunice, Brno

150 06

Fakultni nemocnice Motol, Prague

779 00

Fakultni nemocnice Olomouc, Olomouc

115 28

Alexandra Hospital, Athens

711 10

University General Hospital of Heraklion, Heraklion

570 01

European Interbalkan Medical Center, Thessaloniki

00161

Policlinico Umberto I, Rome

00144

Istituto Nazionale Tumori Regina Elena, Rome

464-8681

Aichi Cancer Center Hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa

060-8648

Hokkaido University Hospital, Sapporo

650-0017

Kobe University Hospital, Kobe

236-0004

Yokohama City University Hospital, Yokohama

565-0871

Osaka University Hospital, Suita

135-8550

Japanese Foundation for Cancer Research, Koto

810-8563

National Hospital Organization Kyushu Medical Center, Fukuoka

6229 HX

Maastricht UMC+, Maastricht

1066 CX

Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL), Amsterdam

2333 ZA

Leids Universitair Medisch Centrum, Leiden

9713 GR

University Medical Center Groningen, Groningen

44-101

Narodowy Instytut Onkologii - Oddzial w Gliwicach, Gliwice

25-734

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej, Kielce

CF14 2TL

Velindre Cancer Centre, Cardiff

S10 2SJ

Weston Park Hospital, Sheffield

g12OYN

Gartnavel General Hospital, Glasgow

SW3 6JJ

Royal Marsden Hospital (Chelsea), London

NW1 2PG

University College London Hospital, London

SM2 5PT

Royal Marsden Hospital (Sutton), London

Sponsors
All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

lead

Loxo Oncology, Inc.

INDUSTRY

NCT04211337 - A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer | Biotech Hunter | Biotech Hunter