A Study of Nivolumab Plus Bempegaldesleukin (Bempeg/NKTR-214) vs Nivolumab Alone vs Standard of Care in Participants With Bladder Cancer That May Have Invaded The Muscle Wall of the Bladder and Who Cannot Get Cisplatin, A Type of Medicine Given To Treat Bladder Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

114

Participants

Timeline

Start Date

February 5, 2020

Primary Completion Date

June 7, 2023

Study Completion Date

June 7, 2023

Conditions
Bladder CancerBladder TumorMuscle-Invasive Bladder Cancer
Interventions
BIOLOGICAL

Nivolumab

Specified dose on specified days

PROCEDURE

Radical cystectomy (RC)

Surgical removal of the bladder

BIOLOGICAL

Bempegaldesleukin

Specified dose on specified days

Trial Locations (116)

1090

Local Institution - 0123, Vienna

Local Institution - 0101, Brussels

1160

Local Institution - 0150, Vienna

1419

Local Institution - 0096, Capital Federal

1426

Local Institution - 0028, Ciudad Autónoma de Buenos Aires

1900

Local Institution - 0124, La Plata

2250

Local Institution - 0137, Gosford

2610

Local Institution - 0083, Wilrijk

2650

Local Institution - 0098, Edegem

3065

Local Institution - 0157, Fitzroy

3084

Local Institution - 0011, Heidelberg

3350

Local Institution - 0158, Ballarat

4000

Local Institution - 0100, Liège

5000

Local Institution - 0097, Córdoba

6150

Local Institution - 0013, Murdoch

8036

Local Institution - 0148, Graz

9000

Local Institution - 0068, Ghent

10461

Local Institution - 0009, The Bronx

11528

Local Institution - 0178, Athens

12462

Local Institution - 0033, Chaïdári

13273

Local Institution - 0057, Marseille

14004

Local Institution - 0109, Córdoba

14059

Local Institution - 0021, Prague

14263

Local Institution - 0004, Buffalo

15006

Local Institution - 0104, A Coruña

15125

Local Institution - 0088, Athens

18103

Local Institution - 0005, Allentown

20089

Local Institution - 0044, Rozzano

20132

Local Institution - 0162, Milan

20133

Local Institution - 0025, Milan

20246

Local Institution - 0052, Hamburg

22763

Local Institution - 0051, Hamburg

23040

Local Institution - 0154, La Paz

23538

Local Institution - 0053, Lübeck

27100

Local Institution, Pavia

28007

Local Institution - 0105, Madrid

28034

Local Institution - 0108, Madrid

28041

Local Institution - 0103, Madrid

29000

Local Institution - 0064, Quimper

29425

Local Institution - 0007, Charleston

31096

Local Institution - 0129, Haifa

33075

Local Institution - 0091, Bordeaux

34298

Local Institution - 0075, Montpellier

37000

Local Institution - 0074, Tours

39008

Local Institution - 0107, Santander

40225

Local Institution - 0117, Düsseldorf

41013

Local Institution - 0111, Seville

44625

Local Institution - 0049, Herne

45147

Local Institution - 0050, Essen

48149

Local Institution - 0113, Münster

50134

Local Institution - 0149, Florence

51726

Local Institution - 0161, Reims

52242

Local Institution - 0002, Iowa City

52621

Local Institution - 0130, Tel Litwinsky

55905

Local Institution, Rochester

56126

Local Institution - 0026, Pisa

56429

Local Institution - 0035, Thessaloniki

63011

Local Institution - 0151, Clermont-Ferrand

64460

Local Institution - 0133, Monterrey

67200

Local Institution - 0058, Strasbourg

69008

Local Institution - 0071, Lyon

72076

Local Institution - 0046, Tübingen

75014

Local Institution - 0062, Paris

75908

Local Institution - 0060, Paris

76508

Local Institution - 0023, Temple

77030

Local Institution - 0139, Houston

77900

Local Institution - 0022, Olomouc

84918

Local Institution - 0077, Avignon

85000

Local Institution - 0059, La Roche-sur-Yon

85234

Local Institution - 0080, Gilbert

85724

Local Institution - 0136, Tucson

90419

Local Institution - 0048, Nuremberg

91054

Local Institution - 0119, Erlangen

92151

Local Institution - 0056, Suresnes

92868

Local Institution - 0015, Orange

98109

Local Institution - 0102, Seattle

98332

Local Institution - 0122, Gig Harbor

197758

Local Institution, Saint Petersburg

250117

Local Institution, Jinan

361003

Local Institution, Xiamen

400016

Local Institution - 0204, Chongqing

410031

Local Institution, Changsha

430022

Local Institution, Wuhan

450000

Local Institution, Zhengzhou

644013

Local Institution, Omsk

6423906

Local Institution - 0131, Tel Aviv

14784400

Local Institution - 0176, Barretos

92092-0698

Local Institution - 0029, La Jolla

08903

Local Institution - 0006, New Brunswick

C1280AEB

Local Institution - 0027, Capital Federal

S2000DTC

Local Institution - 0174, Rosario

90560-030

Local Institution - 0177, Porto Alegre

91350-200

Local Institution - 0039, Porto Alegre

17210-120

Local Institution - 0037, Jaú

01509-010

Local Institution - 0038, São Paulo

20231-050

Local Institution - 0041, Rio de Janeiro

01246-000

Local Institution - 0040, São Paulo

L1G 2B9

Local Institution - 0082, Oshawa

G1R3S1

Local Institution - 0018, Québec

JiH 5N4

Local Institution - 0036, Sherbrooke

Unknown

Local Institution, Taiyuan

150 06

Local Institution - 0020, Prague

06189

Local Institution - 0070, Nice

01307

Universitatsklinikum Carl Gustav Carus, Dresden

07747

Local Institution - 0045, Jena

00168

Local Institution - 0065, Roma

06100

Local Institution - 0132, Mexico City

06700

Local Institution - 0160, Mexico City

1066 CX

Local Institution - 0069, Amsterdam

21-505

Local Institution - 0167, Biała Podlaska

02-781

Local Institution - 0054, Warsaw

08916

Local Institution - 0106, Badalona

08035

Local Institution - 0110, Barcelona

SG1 4AB

Local Institution, Stevenage

LE1 5WW

Local Institution - 0085, Leicester

W6 8RF

Local Institution - 0042, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Nektar Therapeutics

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY