A Phase II Study of Chemoradiotherapy With Nimotuzumab in Unresectable Esophageal Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

November 14, 2019

Primary Completion Date

December 30, 2022

Study Completion Date

June 30, 2023

Conditions
Esophageal CancerChemoradiotherapyNimotuzumabUnresectable Malignant Neoplasm
Interventions
RADIATION

Radiotherapy

44.94Gy and 37.8Gy in 21 fractions to PGTV and PTV for neoadjuvant treatment. 59.92Gy and 50.4Gy in 28 fractions to PGTV and PTV for definitive treatment.

DRUG

Nimotuzumab

400mg, by intravenous infusion once a week in 4-6 weeks.

DRUG

S-1

40-60mg/m2/d,orally twice a day concurrently with radiotherapy.

Trial Locations (1)

100021

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing

All Listed Sponsors
lead

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

OTHER

NCT04207918 - A Phase II Study of Chemoradiotherapy With Nimotuzumab in Unresectable Esophageal Cancer | Biotech Hunter | Biotech Hunter