71
Participants
Start Date
January 7, 2020
Primary Completion Date
February 28, 2022
Study Completion Date
February 28, 2022
VRC-MALMAB0100-00-AB
VRC-MALMAB0100-00-AB (CIS43LS) is a monoclonal antibody that recognizes a unique and conserved region of the Plasmodium falciparum (P. falciparum) circumsporozoite protein and incorporates an LS mutation to increase product half-life in plasma.
Plasmodium falciparum (P. falciparum) sporozoite challenge
Participants were exposed to bites on the forearm from Anopheles stephensi mosquitoes infected with P. falciparum (3D7 strain).
VRC Clinic, NIH Clinical Center, Bethesda
University of Maryland Baltimore, Center for Vaccine Development, Baltimore
National Institute of Allergy and Infectious Diseases (NIAID)
NIH