Platinum-Based Chemotherapy With/Without INCMGA00012, an Anti-PD-1 Antibody, in Non-Small Cell Lung Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

583

Participants

Timeline

Start Date

September 11, 2020

Primary Completion Date

December 15, 2023

Study Completion Date

August 28, 2026

Conditions
Metastatic Squamous Non-Small Cell Lung CancerMetastatic Nonsquamous Non-Small Cell Lung Cancer
Interventions
DRUG

Retifanlimab

INCMGA00012 administered intravenously every 3 weeks on Day 1 of each cycle for up to 35 cycles.

DRUG

Placebo

Placebo administered intravenously every 3 weeks on Day 1 of each cycle for up to 35 cycles.

DRUG

Pemetrexed

Pemetrexed administered intravenously every 3 weeks on Day 1 of each cycle.

DRUG

Cisplatin

Cisplatin administered intravenously every 3 weeks on Day 1 of each cycle for 4 cycles.

DRUG

Carboplatin

Carboplatin administered intravenously every 3 weeks on Day 1 of each cycle for 4 cycles.

DRUG

Paclitaxel

Paclitaxel administered intravenously every 3 weeks on Day 1 of each cycle for 4 cycles.

DRUG

nab-Paclitaxel

nab-Paclitaxel administered intravenously every 3 weeks on Days 1, 8, and 15 of each cycle for 4 cycles.

Trial Locations (140)

10000

National Lung Hospital, Hanoi

10990

Hospital Pulau Pinang, Pulau Pinang

11000

Clinical Center Bezanijska Kosa, Belgrade

Clinical Center of Serbia, Belgrade

Oncomed-System, Belgrade

13200

Advanced Medical and Dental Institute Husm, Kepala Batas

19612

Reading Hospital and Medical Center, Reading

21204

Institute For Pulmonary Diseases of Vojvodina, Kamenitz

22030

Trakya Universitesi Tip Fakultesi, Edirne

25006

Pp Ppc Acinus Medical and Diagnostic Centre, Kropyvnytskyi

25100

Hospital Tengku Ampuan Afzan, Kuantan

27310

Gaziantep University Gaziantep Oncology Hospital, Gaziantep

34000

Clinical Center Kragujevac, Kragujevac

34098

Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty, Istanbul

34147

Bakirkoy Dr Sadi Konuk Teaching and Research Hospital, Istanbul

34214

Medipol University Medical Faculty, Istanbul

35530

Izmir Medicalpark Hospital, Izmir

40022

Rmi Sumy Regional Clinical Oncology Dispensary, Sumy

42080

Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi, Konya

43018

Volyn Regional Oncological Dispensary, Lutsk

44280

Inonu Universitesi Turgut Ozal Tip Merkezi, Malatya

46050

Beacon Hospital Sdn Bhd, Petaling Jaya

49102

Multifield Clinical Hospital No 4, Dnipro

50048

Mi Kryviy Rih Center of Dnipropetrovsk Regional Council, Kryvyi Rih

50333

University Hospital Hradec Kralove, Hradec Králové

59100

University Malaya Medical Centre, Kuala Lumpur

61070

Communal Non-Profit Enterprise Regional Center of Oncology, Kharkiv

61103

V.T.Zaycev Institute of General and Urgent Surgery of National Academy Medical Sciences of Ukraine, Kharkiv

62250

Institut Kanser Negara - National Cancer Institute, Putrajaya

69059

Medical Center Oncolife Llc, Zaporizhzhia

73000

Kherson Regional Oncologic Dispensary, Kherson

76018

Ci Carpathian Clinical Oncological Center, Ivano-Frankivsk

88000

Cne Ccch of Uzh Cc Oncological Center, Uzhhorod

90603

Innovative Clinical Research Institute, Whittier

92801

Pacific Cancer Medical Center, Anaheim

93586

Sarawak General Hospital, Kuching

100000

Bach Mai Hospital, Hanoi

Hanoi Oncology Hospital, Hanoi

National Cancer Hospital, Hanoi

121309

"Federal State Institution Russian Cancer Research Center Named After N.N. Blokhin Rams", Moscow

150081

Harbin Medical University Cancer Hospital, Harbin

163045

Sbih of Arkhangelsk Region Arkhangelsk Clinical Oncological Dispensary, Arkhangelsk

197022

Pavlov First Saint Petersburg State Medical University, Saint Petersburg

197758

N.N. Petrov Research Institute of Oncology, Saint Petersburg

200030

Shanghai Chest Hospital, Shanghai

230001

University of Science and Technology of China-First Affiliated Hospital (Anhui Provincial Hospital), Hefei

230601

The Second Hospital of Anhui Medical University, Hefei

250013

Jinan Central Hospital, Jinan

276001

Linyi Cancer Hospital, Linyi

300052

General Hospital of Tianjin, Tianjing

300166

S C Oncocenter Oncologie Medicala S R L, Timișoara

300239

Oncomed Srl, Timișoara

305035

Rbih Kursk Regional Clinical Oncology Dispensary of Kursk Region Healthcare Committee, Kursk

310001

Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou

310002

Hangzhou Cancer Hospital, Hangzhou

310003

The First Affiliated Hospital of Zhejiang University, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

330006

The Second Affiliated Hospital of Nanchang University, Nanchang

400015

Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca, Cluj-Napoca

400132

Spitalul Clinic Militar de Urgenta Dr. Constantin Papilian Cluj-Napoca, Cluj-Napoca

400138

Sbhi Volgograd Regional Onclogy Dispensary, Volgograd

410013

Hunan Cancer Hospital, Changsha

430295

S.C Oncopremium Team S.R.L, Baia Mare

450003

Henan Cancer Hostipal, Zhengzhou

Henan Provincial Peoples Hospital, Zhengzhou

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

510080

The First Affiliated Hospital Sun Yat-Sen University, Guangzhou

530021

The First Affiliated Hospital of Guangxi Medical University, Nanning

603089

Llc Tonus, Nizniy Novgorod

630108

Sbhi of Novosibirsk Region Novosibirsk Regional Oncological Dispensary, Novosibirsk

644013

Bhi of Omsk Region Clinical Oncology Dispensary, Omsk

722681

Hcmc Oncology Hospital, Ho Chi Minh City

830000

The Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi

900591

Spitalul Clinic Judetean de Urgenta Constanta, Constanța

14784-400

Fundacao Pio Xii Hospital de Cancer de Barretos, Barretos

95010-005

Incan - Instituto Do Cancer - Hospital Pompeia, Caxias do Sul

60336-045

Centro Regional Integrado de Oncologia, Fortaleza

98700-000

Oncosite - Centro de Pesquisa Clinica E Oncologia, Ijuí

88301-220

Clinica de Neoplasias Litoral Ltda, Itajaí

86015-520

Hospital Do Cancer de Londrina, Londrina

99010-120

Instituto Mederi de Pesquisa E Saude, Passo Fundo

90470-340

Hgb - Hospital Giovanni Battista - Mae de Deus Center, Porto Alegre

20230-130

Inca - Instituto Nacional de Cancer, Rio de Janeiro

03102-002

Sao Camilo Oncologia, S?O Paulo

09060-870

Cepho - Centro de Estudos E Pesquisas de Hematologia E Oncologia, Santo André

15090-000

Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto, São José

01330

Mc Women'S Health-Nadezhda Eood, Sofia

01407

Acibadem Cityclinica Mhat Tokuda, Sofia

01431

Umhat Sv. Ivan Rilski Ead, Sofia

01632

Mhat Serdika Eood, Sofia

01797

Multiprofile Hospital For Active Treatment Central Onco Hospital Ood, Sofia

09002

Shatod Dr Marko Marko - Varna Ltd, Varna

775 20

Fakultni Nemocnice Olomouc, Olomouc

703 84

Nemocnice Agel Ostrava - Vitkovice A.S, Ostrava - Vitkovice

150 06

Fakultni Nemocnice V Motole, Prague

06000

High Technology Hospital Medcenter, Batumi

Bacs Kiskun Megyei Oktatokorhaz, Kecskemét

Cebu Doctors University Hospital, Cebu City

04600

Jsc Evex Hospitals, Kutaisi

00102

Archangel St. Michael Multi Profile Clinical Hospital, Tbilisi

00112

Israel-Georgian Medical Research Clinic Helsicore, Tbilisi

00114

New Hospitals, Tbilisi

00141

Medulla Chemotherapy and Immunotherapy Clinic, Tbilisi

Tbilisi State Medical University First University Clinic, Tbilisi

00144

High Technology Medical Center, University Clinic, Tbilisi

00159

Institute of Clinical Oncology Ltd, Tbilisi

00177

Cancer Research Center Ltd, Tbilisi

01121

Orszagos Koranyi Tbc Es Pulmonological Intezet, Budapest

01781

Asian Hospital and Medical Center, City of Muntinlupa

08000

Davao Doctors Hospital, Davao City

05000

West Visayas State University Medical Center, Iloilo City

01229

Makati Medical Center, Makati

Makati Medical Center, Makati City

01000

Philippine General Hospital, Manila

01605

The Medical City, Pasig

01102

St. Lukes Medical Center, Quezon City

21-500

Ko-Med Centra Kliniczne Biala Podlaska, Biała Podlaska

62-500

Przychodnia Lekarska Komed, Konin

30-363

Centrum Medyczne Plejady, Krakow

90-242

Centrum Terapii Wspolczesnej J.M. Jasnorzewska Sp. Komandytowo-Akcyjna, Lodz

60-693

Przychodnia Med-Polonia Sp. Z O.O., Poznan

11 000

Clinical Center of Serbia, Belgrade

07570

Cape Town Oncology Trials (Pty) Ltd, Cape Town

07700

Cancercare Rondebosch Oncology Centre, Cape Town

02193

Wits Clinical Research, Johannesburg

02196

Sandton Oncology Centre, Johannesburg

00002

University of Pretoria Oncology Department, Pretoria

00181

Mary Potter Oncology Centre, Pretoria

01130

Acibadem Adana Hospital, Adana

01230

Adana Sehir Hastanesi, Adana

06100

Hacettepe Universitesi Tip Fakultesi Hastanesi, Ankara

06105

Dr. Abdurrahman Yurtaslan Onkology Teaching and Research Hospital, Ankara

06520

Memorial Ankara Hospital, Ankara

06800

Yildirim Beyazit University Ankara Ataturk Training and Research Hospital, Ankara

07020

Memorial Antalya Hastanesi, Antalya

03115

Kyiv City Clinical Oncological Center, Kyiv

03126

Medical Center Asklepion Llc, Kyiv

04107

Ci of Krc Kyiv Regional Oncologic Dispensary, Kyiv

00000

Can Tho Oncology Hospital, Can Tho

103 Military Hospital, Hanoi

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY