Immune Equivalence Between Multi-dose and Single Dose Formulation of Vi-DT and Their Overall Safety (Phase III)

PHASE3CompletedINTERVENTIONAL
Enrollment

1,800

Participants

Timeline

Start Date

February 4, 2020

Primary Completion Date

September 11, 2020

Study Completion Date

January 29, 2021

Conditions
Typhoid
Interventions
BIOLOGICAL

Vi-DT (Multi-dose formulation)

"* Manufacturer: SK bioscience Co., Ltd.~* Dose formulation: 25 µg Vi polysaccharide /0.5 mL, presented in Type I glass vial (multi dose Vi-DT with preservative 2 PE)~* Mode of Administration: 0.5 mL by intramuscular injection in the left anterolateral thigh or left arm deltoid region in participants below 2 years of age, less dominant arm deltoid region in age group 2 to 45 years~* Storage Conditions: +2 to +8°C"

BIOLOGICAL

Vi-DT (Single dose formulation)

"* Manufacturer: SK bioscience Co., Ltd.~* Dose formulation: 25 µg Vi polysaccharide /0.5 mL, presented in Type I glass vial (single dose Vi-DT without any preservative)~* Mode of Administration: 0.5 mL by intramuscular injection in the left anterolateral thigh or left arm deltoid region in participants below 2 years of age, less dominant arm deltoid region in age group 2-45 years~* Storage Conditions: +2 to +8°C"

BIOLOGICAL

Control Vaccine

"* For participant ≥ 1 year one dose of locally licensed Meningococcal conjugate vaccine will be administered~* For participants 6 months to 1 year one dose of locally licensed Meningococcal conjugate vaccine will be administered during the study and the next dose will be provided after the study unblinding at the completion of 6 months follow up of last subject."

Trial Locations (4)

1000

University of the Philippines Manila-National Institutes of Health, Manila

1772

Putatan Research Center, Muntinlupa

4000

Magcase Health Center, San Pablo

4027

Lingga Health Research Center, Calamba

All Listed Sponsors
collaborator

SK Bioscience Co., Ltd.

INDUSTRY

collaborator

Bill and Melinda Gates Foundation

OTHER

lead

International Vaccine Institute

OTHER

NCT04204096 - Immune Equivalence Between Multi-dose and Single Dose Formulation of Vi-DT and Their Overall Safety (Phase III) | Biotech Hunter | Biotech Hunter