511
Participants
Start Date
February 5, 2020
Primary Completion Date
May 30, 2023
Study Completion Date
March 31, 2025
Lenvatinib
Lenvatinib, 20 mg (two 10-mg oral capsules) administered QD
Pembrolizumab
Pembrolizumab (MK-3475), 200 mg, every 3 weeks (Q3W) by intravenous (IV) infusion for up to 35 3-week cycles
Placebo
Lenvatinib-matching placebo, oral capsules, administered once daily (QD)
National Cheng Kung University Hospital ( Site 1603), Dawan
Chang Gung Medical Foundation. Kaohsiung Branch ( Site 1604), Kaohsiung City
Orszagos Onkologiai Intezet ( Site 2202), Budapest
Uzsoki Utcai Korhaz ( Site 2201), Budapest
Chris OBrien Lifehouse ( Site 1002), Camperdown
St George Hospital ( Site 1001), Kogarah
Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Okta-Klinikai Onkológiai és Sugárterápiás Ce, Miskolc
Debreceni Egyetem Klinikai Kozpont ( Site 2206), Debrecen
Royal Adelaide Hospital ( Site 1004), Adelaide
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 2200), Szolnok
Szegedi Egyetem Szent-Gyorgyi Albert Klinikai Kozpont ( Site 2207), Szeged
Weill Cornell Medicine New York Presbyterian Hospital ( Site 0040), New York
National Taiwan University Hospital ( Site 1600), Taipei
MacKay Memorial Hospital ( Site 1602), Taipei
Taipei Veterans General Hospital ( Site 1601), Taipei
Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 2112), Berlin
Hopital de la Timone ( Site 1903), Marseille
SUNY Upstate Medical University ( Site 0051), Syracuse
Seoul National University Bundang Hospital ( Site 1205), Seongnam-si
Hospital Nacional Guillermo Almenara Irigoyen ( Site 0700), Lima
Hospital Nacional Edgardo Rebagliati Martins ( Site 0702), Lima
Hospital Nacional Arzobispo Loayza ( Site 0703), Lima
Hospital Nacional Cayetano Heredia ( Site 0704), Lima
Ajou University Hospital ( Site 1200), Suwon
ASL Liguria 2 - Ospedale San Paolo ( Site 2401), Savona
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 2400), Milan
IEO Istituto Europeo di Oncologia ( Site 2406), Milan
ASST Santi Paolo e Carlo - Presidio Ospedaliero San Paolo ( Site 2405), Milan
Trakya Universitesi Tip Fakultesi ( Site 2801), Edirne
Inova Schar Cancer Institute ( Site 0009), Fairfax
Blue Ridge Cancer Care ( Site 0015), Blacksburg
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia ( Site 2402), Brescia
University of North Carolina- Chapel Hill ( Site 0056), Chapel Hill
Duke Cancer Center ( Site 0044), Durham
Hospital Universitario 12 de Octubre ( Site 2702), Madrid
Hospital Universitario La Paz ( Site 2706), Madrid
Northwest Georgia Oncology Centers PC ( Site 0028), Marietta
KRH Klinikum Siloah ( Site 2103), Hanover
Georgia Cancer Center at Augusta University ( Site 0013), Augusta
Memorial Regional Hospital-Memorial Cancer Institute ( Site 0069), Hollywood
Medipol Universite Hastanesi ( Site 2800), Istanbul
Ege Universitesi Tip Fakultesi Hastanesi ( Site 2804), Izmir
Istituto Oncologico Veneto ( Site 2404), Padua
Medical Park Izmir Hospital ( Site 2807), Izmir
University of Louisville, James Graham Brown Cancer Center ( Site 0045), Louisville
Hospital de Valme ( Site 2705), Seville
Keimyung University Dongsan Hospital ( Site 1203), Daegu
Inonu Universitesi Turgut Ozal Tip Merkezi ( Site 2803), Malatya
Karmanos Cancer Institute ( Site 0054), Detroit
Henry Ford Health System ( Site 0001), Detroit
Hospital Clinico Universitario Lozano Blesa ( Site 2703), Zaragoza
Universitaetsklinikum Koeln ( Site 2111), Cologne
University of Wisconsin- Madison Carbone Cancer Center ( Site 0006), Madison
Chonnam National University Hwasun Hospital ( Site 1202), Hwasun-gun
St. Vincent Frontier Cancer Center ( Site 0008), Billings
Universitaetsklinikum Frankfurt ( Site 2107), Frankfurt am Main
Washington University School of Medicine ( Site 0060), St Louis
"Hospital Universitario Dr. Jose Eleuterio Gonzalez ( Site 0602)", Monterrey
Christus Muguerza Clinica Vidriera ( Site 0607), Monterrey
University of Kansas Cancer Center ( Site 0033), Westwood
Oaxaca Site Management Organization S.C. ( Site 0603), Oaxaca City
Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0053), Omaha
Centre Leon Berard ( Site 1901), Lyon
Universitaetsklinikum Tuebingen ( Site 2108), Tübingen
Centre Henri Becquerel ( Site 1904), Rouen
Centro de Investigacion y Avances Medicos Especializados -CIAME ( Site 0604), Cancún
University of Colorado Cancer Center ( Site 0023), Aurora
Universitaetsklinikum Ulm ( Site 2102), Ulm
California Cancer Associates for Research & Excellence ( Site 0059), San Marcos
Hopital Foch ( Site 1905), Suresnes
Universitaetsklinikum Regensburg ( Site 2100), Regensburg
California Cancer Associates for Research & Excellence ( Site 0025), Fresno
Gustave Roussy ( Site 1906), Villejuif
Providence Portland Medical Center ( Site 0048), Portland
Cancer Care Northwest ( Site 0017), Spokane Valley
Peking Union Medical College Hospital ( Site 3304), Bejiing
Beijing Cancer Hospital ( Site 3314), Beining
FSCC FMBA of Russia ( Site 2603), Moscow
Jilin Cancer Hospital ( Site 3310), Changchun
Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 2605), Yaroslavl
The Third Affiliated Hospital of Harbin Medical University ( Site 3302), Harbin
Fudan University Shanghai Cancer Center ( Site 3324), Shanghai
Shanghai East Hospital ( Site 3300), Shanghai
Tianjin Medical University Cancer Hospital ( Site 3312), Tianjin
Zhejiang Cancer Hospital ( Site 3303), Hangzhou
Jiangxi Cancer Hospital ( Site 3313), Nanchang
Fujian Provincial Cancer Hospital ( Site 3326), Fuzhou
Chongqing Cancer Hospital ( Site 3327), Chongqing
Hunan Cancer Hospital ( Site 3311), Changsha
Xiangya Hospital of Central South University ( Site 3305), Changsha
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 2609), Kazan'
Wuhan Union hospital Cancer Center ( Site 3307), Wuhan
Tongji Hospital Tongji Medical,Science & Technology ( Site 3316), Wuhan
Henan Cancer Hospital ( Site 3309), Zhengzhou
Guangxi Medical University Affiliated Tumor Hospital ( Site 3322), Nanning
Guizhou Cancer Hospital ( Site 3330), Guiyang
West China Hospital of Sichuan University ( Site 3308), Chengdu
Altay Regional Oncology Dispensary ( Site 2611), Barnaul
The First Affiliated Hospital of Xi an Jiaotong University ( Site 3328), Xi'an
Yokohama City University Hospital ( Site 1104), Yokohama
National Cancer Center Hospital East ( Site 1100), Kashiwa
Aichi Cancer Center Hospital ( Site 1113), Nagoya
Kindai University Hospital ( Site 1107), Sayama
Hiroshima University Hospital ( Site 1109), Hiroshima
University of Connecticut Health Center ( Site 0020), Farmington
Dana Farber Cancer Institute ( Site 0019), Boston
University of Michigan ( Site 0064), Ann Arbor
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0002), Hackensack
Oncocentro Ceara ( Site 0412), Fortaleza
Fundacao Sao Francisco Xavier ( Site 0409), Ipatinga
ELO Pesquisa Clinica ( Site 0405), Maringá
Hospital de Passo Fundo ( Site 0401), Passo Fundo
Clinica LACKS ( Site 0402), Pelotas
Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 0414), Porto Alegre
A.C. Camargo Cancer Center ( Site 0407), São Paulo
Princess Margaret Cancer Centre ( Site 0200), Toronto
McGill University Health Centre ( Site 0206), Montreal
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0, Québec
Universitätsklinikum Leipzig-Department for ENT ( Site 2106), Leipzig
Nagoya University Hospital ( Site 1106), Nagoya
Chiba cancer center ( Site 1110), Chiba
Hyogo Cancer Center ( Site 1112), Akashi
Kagawa University Hospital ( Site 1108), Kita-gun
Shizuoka Cancer Center Hospital and Research Institute ( Site 1105), Sunto-gun
National Hospital Organization Kyushu Medical Center ( Site 1111), Fukuoka
National Cancer Center Hospital ( Site 1102), Tokyo
The Cancer Institute Hospital of JFCR ( Site 1103), Tokyo
Tokyo Medical and Dental University Hospital ( Site 1101), Tokyo
Cryptex Investigación Clínica S.A. de C.V. ( Site 0608), Cuauhtémoc, Mexico City
Instituto Nacional de Enfermedades Neoplasicas ( Site 0701), Lima
Przychodnia Lekarska Komed ( Site 2500), Konin
Szpital Kliniczny im. Heliodora Swiecickiego Uniwers Medyczn ( Site 2509), Poznan
Centrum Onkologii im prof Franciszka Lukaszczyka ( Site 2508), Bydgoszcz
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 2502), Krakow
Dolnoslaskie Centrum Onkologii. ( Site 2507), Wroclaw
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Glowy i Szyi ( Site, Warsaw
Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 2504), Gdynia
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2506), Gliwice
Asan Medical Center ( Site 1201), Songpa-gu
The Catholic University of Korea Eunpyeong St Mary s Hospital ( Site 1204), Seoul
Hospital Duran i Reynals ( Site 2701), L'Hospitalet de Llobregat
H.U. Vall de Hebron ( Site 2700), Barcelona
Hacettepe Universitesi Tip Fakultesi ( Site 2805), Ankara
Ankara Sehir Hastanesi ( Site 2802), Ankara
Aberdeen Royal Infirmary ( Site 2905), Aberdeen
Guy's Hospital in London ( Site 2908), London
Royal Marsden NHS Foundation Trust ( Site 2910), London
Mount Vernon Cancer Centre ( Site 2902), Northwood
Royal Marsden Hospital ( Site 2904), Sutton
Nottingham City Hospital ( Site 2907), Nottingham
Taunton and Somerset Hospital ( Site 2900), Taunton
Christie NHS Foundation Trust ( Site 2903), Manchester
Eisai Inc.
INDUSTRY
Merck Sharp & Dohme LLC
INDUSTRY