Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD)

PHASE2CompletedINTERVENTIONAL
Enrollment

205

Participants

Timeline

Start Date

January 3, 2020

Primary Completion Date

September 1, 2022

Study Completion Date

September 1, 2022

Conditions
Non-Alcoholic Fatty Liver DiseaseNon-Alcoholic Fatty LiverNon-Alcoholic Steatohepatitis
Interventions
DIETARY_SUPPLEMENT

Vitamin E [(all-rac)-α-tocopheryl acetate]

Vitamin E (1000 mg) once daily for 6 months (1 capsule) and matching placebos (2 matched capsules) for 6 months

DIETARY_SUPPLEMENT

Omega-3 fatty acid (DHA EE)

DHA EE (1.89 g) once daily for 6 months (2 capsules) and matching placebo for DHA EE (1 matched capsule for 6 months)

COMBINATION_PRODUCT

Omega-3 fatty acid (DHA EE) & Vitamin E [(all-rac)-α-tocopheryl acetate]

DHA EE (1.89 g) once daily for 6 months and Vitamin E (1000 mg) once daily for 6 months

OTHER

Placebo

Matching soybean placebo (3 capsules) of all arms daily for 6 months.

Trial Locations (15)

27612

M3 Wake Research Associates, Raleigh

30607

Summit Clinical Research LLC, Athens

33012

Indago Research and Health Center, Inc., Hialeah

33147

Advanced Pharma CR LLC, Miami

33165

Med-Care Research, Miami

33166

Integrity Clinical Research LLC, Doral

34211

Florida Research Institute, Lakewood Rch

46202

Indiana University School of Medicine, Indianapolis

72117

Arkansas Gastroenterology, North Little Rock

77058

Centex Studies, Inc., Houston

77479

Liver Specialists of Texas/Mt. Olympus Medical Research, Houston

78215

American Research Corporation at the Texas Liver Institute, San Antonio

85712

Arizona Liver Health, Chandler

Arizona Liver Health, Tucson

92377

Inland Empire Clinical Trials, LLC, Rialto

All Listed Sponsors
collaborator

DSM Nutritional Products, Inc.

INDUSTRY

lead

Naga P. Chalasani

OTHER

NCT04198805 - Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD) | Biotech Hunter | Biotech Hunter