20
Participants
Start Date
April 3, 2020
Primary Completion Date
August 28, 2023
Study Completion Date
August 27, 2024
Cryoneurolysis with a Painblocker (Epimed International, Farmers Branch, Texas)
The cryoneurolysis device will be triggered using 2 cycles of 2-minute gas activation separated by 1-minute defrost periods. For active probes, the nitrous oxide will be deployed to the tip where a drop in temperature to -70°C will result in cryoneurolysis.
Intercostal nerve block ropivacaine with epinephrine
3 mL of ropivacaine 0.5% (with epinephrine) will be injected perineurally to provide the intercostal nerve block(s)
Sham cryoneurolysis with a Painblocker
The cryoneurolysis device will be triggered using 2 cycles of 2-minute gas activation separated by 1-minute defrost periods. For the sham probes, the nitrous oxide will be vented prior to reaching the probe shaft, resulting in a lack of perineural temperature change.
Placebo intercostal nerve block with normal saline
3 mL of normal saline will be injected perineurally to provide placebo intercostal nerve blocks
University California San Diego, San Diego
University of California, San Diego
OTHER