Oral Infigratinib for the Adjuvant Treatment of Subjects With Invasive Urothelial Carcinoma With Susceptible FGFR3 Genetic Alterations

PHASE3TerminatedINTERVENTIONAL
Enrollment

39

Participants

Timeline

Start Date

March 11, 2020

Primary Completion Date

February 28, 2023

Study Completion Date

February 28, 2023

Conditions
Upper Tract Urothelial CarcinomasUrothelial Bladder Cancer
Interventions
DRUG

Infigratinib

Participants randomly assigned to infigratinib will receive hard gelatin capsules for oral administration of infigratinib 125 mg once a day (administered as one 100-mg capsule and one 25-mg capsule) using a 3 weeks on (Days 1-21) /1 week off (Days 22-28) dosing schedule.

DRUG

Placebo

Participants randomly assigned to placebo will receive placebo matching in appearance the investigational product (infigratinib), which will be provided as hard gelatin capsules for oral use and will be administered once daily on a 3 weeks on (Days 1-21) /1 week off (Days 22-28) dosing schedule.

Trial Locations (143)

1200

Cliniques Universitaires Saint-Luc, Brussels

4000

CHU de Liège - Sart Tilman, Liège

8001

University Multiprofile Hospital For Active Treatment Deva Maria, Burgas

10043

Azienda Ospedaliero - Universitaria San Luigi Gonzaga, Orbassano

10117

Charité - Universitatsmedizin Berlin, Berlin

11526

Henry Dunant Hospital Center, Athens

12208

Albany Medical Center - Division of Urology, Albany

13210

Associated Medical Professionals - Syracuse, Syracuse

14004

Hospital Universitario Reina Sofía, Córdoba

16132

Ospedale Policlinico San Martino, Genova

17007

Institut Català d'Oncologia Girona, Girona

20007

Georgetown University Medical Center, Washington D.C.

20141

Istituto Europeo di Oncologia, Milan

21287

Johns Hopkins Hospital, Baltimore

26100

Ospedale di Cremona, Cremona

26506

West Virginia University, Morgantown

27157

Wake Forest Baptist Health, Winston-Salem

27609

Accellacare-DuPage Medical Group, Raleigh

27710

Duke University Cancer Center, Durham

28033

MD Anderson Cancer Center Madrid, Madrid

28034

Hospital Universitario Ramon y Cajal, Madrid

28040

Hospital Clinico San Carlos, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28050

Hospital Universitario HM Sanchinarro, Madrid

28222

Hospital Universitario Puerta Hierro-Majadahonda, Majadahonda

29200

Hôpital Morvan, Brest

29425

Medical University of South Carolina, Charleston

30322

Emory University, Atlanta

Winship Cancer Institute of Emory University, Atlanta

31059

Institut Claudius Regaud, Toulouse

32224

Mayo Clinic - Jacksonville, Jacksonville

33016

Urological Research Network CORP, Hialeah

33805

Lakeland Regional Health Hollis Cancer Center, Lakeland

35042

Centre Eugène Marquis, Rennes

35760

Centre Hospitalier Privé Saint-Grégoire, Saint-Grégoire

37209

Urology Associates, Nashville

38100

Ospedale di Trento - Presidio Ospedaliero Santa Chiara, Trento

40225

Universitätsklinikum Düsseldorf, Düsseldorf

41013

Hospital Universitario Virgen del Rocio, Seville

42100

Arcispedale Santa Maria Nuova, Reggio Emilia

43210

The Ohio State University College of Medicine, Columbus

43606

University of Toledo, Arlington

43614

The University of Toledo Medical Center, Toledo

44195

Cleveland Clinic, Cleveland

44600

Clinique Mutualiste de l'Estuaire, Saint-Nazaire

44625

Marien Hospital Herne - Universitätsklinikum der Ruhr-Universität Bochum, Herne

45005

Hospital Virgen De La Salud, Toledo

45147

Universitätsklinikum Essen, Essen

45242

Oncology Hematology Care, Cincinnati

46009

Fundacion Instituto Valenciano de Oncologia, Valencia

46202

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

47014

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

47179

Urologicum Duisburg, Duisburg

54622

Bioclinic Thessalonikis, Thessaloniki

56126

Azienda Ospedaliero-Universitaria Pisana, Pisa

60532

DuPage Medical Group - Warrenville Road, Lisle

60611

Northwestern University Feinberg School of Medicine, Chicago

60637

UChicago Medicine Duchossois Center for Advanced Medicine (DCAM) - Hyde Park, Chicago

63110

Saint Louis University- SLUCare Academic Pavilion, St Louis

67200

Institut de Cancerologie Strasbourg Europe, Strasbourg

68198

University of Nebraska Medical Center, Omaha

69008

Centre de Lutte Contre le Cancer - Centre Léon Bérard, Lyon

70112

Tulane University/Southeastern Louisiana VA Health Care, New Orleans

70124

Azienda Universitaria Ospedaliera Consorziale - Policlinico di Bari, Bari

73104

Stephenson Cancer Center, Oklahoma City

75013

Hôpital Universitaire Pitié Salpêtrière, Paris

75015

Hôpital Européen Georges-Pompidou, Paris

75018

CHU de Nantes Hopital Hotel Dieu, Paris

75080

UT Southwestern, Richardson

75390

Harold C. Simmons Comprehensive Cancer Center, Dallas

77030

Bayor College of Medicine, Houston

Houston Methodist Hospital- Department of Urology, Houston

The University of Texas MD Anderson Cancer Center, Houston

78229

Urology San Antonio, San Antonio

80045

University of Colorado Cancer Center, Aurora

80131

Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli

80211

The Urology Center of Colorado, Denver

84112

Huntsman Cancer Institute and Hospital, Salt Lake City

85028

IRCCS Centro di Riferimento Oncologico di Basilicata, Rionero in Vulture

85711

Arizona Oncology Associates, Tucson

90033

USC Norris Comprehensive Cancer Center, Los Angeles

91010

City of Hope - Duarte, Duarte

City of Hope, Duarte

92350

Loma Linda University Faculty Medical Clinics, Loma Linda

93053

Caritas-Krankenhaus St. Josef Klinik für Urologie, Regensburg

94805

Gustave Roussy, Villejuif

98109

Seattle Cancer Care Alliance, Seattle

03766

Dartmouth-Hitchcock Medical Center, Lebanon

07601

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack

07663

New Jersey Urology - Saddle Brook, Saddle Brook

08043

New Jersey Urology, Voorhees Township

Unknown

ZNA Middelheim, Antwerp

Universitair Ziekenhuis Leuven, Leuven

University Multiprofile Hospital For Active Treatment Dr. Georgi Stranski EAD, Pleven

"Multiprofile Hospital For Active Treatment Sveta Sofia", Sofia

BC Cancer - Vancouver, Vancouver

CHU de Nantes Hopital Hotel Dieu, Nantes

Hopital Bichat - Claude - Bernard, Paris

Institut De Cancerologie De L'ouest - Site Saint-Herblain, Saint-Herblain

Gustave Roussy, Villejuif

Charite Universitaetsmedizin Berlin, Berlin

Urologie, Berlin

University Hospital Duesseldorf, Düsseldorf

Universitätsklinikum des Saarlandes Klinik für Urologie & Kinderurologie, Homburg

Universitatsklinikum des Saarlandes Klinik fur Urologie & Kinderurologie, Homburg/saar

Universitatsklinikum Magdeburg, Magdeburg

Universitätsklinikum Tübingen, Tübingen

Anassa General Clinic, Volos

Centro di Riferimento Oncologico, Aviano

A.O.U.C. Polclinico di Bari U.O. Oncologia Medica Universitaria, Bari

ASST Cremona, Casalmaggiore

Ospedale Policlinico San Martino Irccs, Genova

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

Fondazione IRCCS INT Milano, Milan

Istituto Europeo di Oncologia, Milan

Int Pascale Napoli, Napoli

AOU San Luigi Gonzaga, Orbassano

Azienda Ospedaliero-Universitaria Pisana, Pisa

IRCCS di Reggio Emilia, Reggio Emilia

Policlinico Universitario Campus Biomedico, Roma

Citta Della Salute e Della Scienz - Torino, Torino

Ospedale di Trento - Presidio Ospedaliero Santa Chiara, Trento

IRCCS Centro di Riferimento Oncologico di Basilicata, Volterra

The Netherlands Cancer Institute, Amsterdam

Zuyderland MC locatie Sittard, Geleen

Hospital de la Santa Creu i Sant Pau, Barcelona

Hospital del Mar, Barcelona

Althaia Xarxa Assistencial Universitària de Manresa, Manresa

Guy's and St Thomas' NHS Foundation Trust, London

Lister Hospital, Stevenage

T6G 1Z2

Cross Cancer Institute, Edmonton

V5Z 4E6

BC Cancer- Vancouver, Vancouver

M5G2M9

Princess Margaret Cancer Centre, Toronto

H4A 3J1

McGill University Health Centre (MUHC), Montreal

G1R 2J6

CHU de Québec Université Laval, Québec

00128

Università Campus Bio-Medico di Roma, Roma

6532 SZ

Canisius-Wilhelmina Ziekenhuis, Nijmegen

08003

VHIO, Barcelona

08041

Sofia, Barcelona

08908

Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet), Barcelona

08916

Institut Català d'Oncologia Badalona, Badalona

08208

Hospital Parc Taulí de Sabadell, Sabadell

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Helsinn Healthcare SA

INDUSTRY

lead

QED Therapeutics, Inc., a Bridgebio company

INDUSTRY