35
Participants
Start Date
October 7, 2020
Primary Completion Date
December 31, 2025
Study Completion Date
December 31, 2025
Biospecimen Collection
Undergo blood sample collection
Computed Tomography
Undergo CT
Echocardiography Test
Undergo ECHO
Magnetic Resonance Imaging
Undergo MRI
Nirogacestat
Given PO
Quality-of-Life Assessment
Ancillary studies
Questionnaire Administration
Ancillary studies
X-Ray Imaging
Undergo x-ray
Starship Children's Hospital, Grafton
The Children's Hospital at Westmead, Westmead
Queensland Children's Hospital, South Brisbane
Perth Children's Hospital, Perth
Christchurch Hospital, Christchurch
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Memorial Sloan Kettering Cancer Center, New York
Montefiore Medical Center - Moses Campus, The Bronx
Albany Medical Center, Albany
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Penn State Children's Hospital, Hershey
Children's Hospital of Philadelphia, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
MedStar Georgetown University Hospital, Washington D.C.
Children's National Medical Center, Washington D.C.
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Children's Hospital of The King's Daughters, Norfolk
Carilion Children's, Roanoke
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Medical University of South Carolina, Charleston
BI-LO Charities Children's Cancer Center, Greenville
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
Nemours Children's Clinic-Jacksonville, Jacksonville
University of Florida Health Science Center - Gainesville, Gainesville
AdventHealth Orlando, Orlando
Nemours Children's Hospital, Orlando
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Johns Hopkins All Children's Hospital, St. Petersburg
Children's Hospital of Alabama, Birmingham
USA Health Strada Patient Care Center, Mobile
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
East Tennessee Childrens Hospital, Knoxville
Saint Jude Children's Research Hospital, Memphis
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
Nationwide Children's Hospital, Columbus
Cleveland Clinic Foundation, Cleveland
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Dayton Children's Hospital, Dayton
Riley Hospital for Children, Indianapolis
C S Mott Children's Hospital, Ann Arbor
Michigan State University, East Lansing
Bronson Methodist Hospital, Kalamazoo
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
Children's Hospital of Wisconsin, Milwaukee
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Lurie Children's Hospital-Chicago, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Saint Jude Midwest Affiliate, Peoria
Washington University School of Medicine, St Louis
Mercy Hospital Saint Louis, St Louis
Children's Mercy Hospitals and Clinics, Kansas City
Children's Hospital New Orleans, New Orleans
Ochsner Medical Center Jefferson, New Orleans
University of Oklahoma Health Sciences Center, Oklahoma City
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Cook Children's Medical Center, Fort Worth
M D Anderson Cancer Center, Houston
University of Texas Health Science Center at San Antonio, San Antonio
Dell Children's Medical Center of Central Texas, Austin
El Paso Children's Hospital, El Paso
Children's Hospital Colorado, Aurora
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
Saint Luke's Cancer Institute - Boise, Boise
Primary Children's Hospital, Salt Lake City
Banner Children's at Desert, Mesa
University Medical Center of Southern Nevada, Las Vegas
Sunrise Hospital and Medical Center, Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
Summerlin Hospital Medical Center, Las Vegas
Renown Regional Medical Center, Reno
Children's Hospital Los Angeles, Los Angeles
Mattel Children's Hospital UCLA, Los Angeles
Kaiser Permanente Downey Medical Center, Downey
Rady Children's Hospital - San Diego, San Diego
Loma Linda University Medical Center, Loma Linda
UCSF Medical Center-Mission Bay, San Francisco
Lucile Packard Children's Hospital Stanford University, Palo Alto
UCSF Benioff Children's Hospital Oakland, Oakland
Kaiser Permanente-Oakland, Oakland
University of California Davis Comprehensive Cancer Center, Sacramento
Kapiolani Medical Center for Women and Children, Honolulu
Oregon Health and Science University, Portland
Arkansas Children's Hospital, Little Rock
Connecticut Children's Medical Center, Hartford
Walter Reed National Military Medical Center, Bethesda
Massachusetts General Hospital Cancer Center, Boston
Dana-Farber Cancer Institute, Boston
Hackensack University Medical Center, Hackensack
Rhode Island Hospital, Providence
Alberta Children's Hospital, Calgary
University of Alberta Hospital, Edmonton
The Montreal Children's Hospital of the MUHC, Montreal
University Pediatric Hospital, San Juan
National Cancer Institute (NCI)
NIH
SpringWorks Therapeutics, Inc.
INDUSTRY
Children's Oncology Group
NETWORK