Study of Olaparib Plus Pembrolizumab Versus Chemotherapy Plus Pembrolizumab After Induction With First-Line Chemotherapy Plus Pembrolizumab in Triple Negative Breast Cancer (TNBC) (MK-7339-009/KEYLYNK-009)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

462

Participants

Timeline

Start Date

December 19, 2019

Primary Completion Date

December 15, 2022

Study Completion Date

November 18, 2025

Conditions
Triple Negative Breast Neoplasms
Interventions
BIOLOGICAL

Pembrolizumab

intravenous (IV) infusion

DRUG

Olaparib

oral tablets

DRUG

Carboplatin

IV infusion

DRUG

Gemcitabine

IV infusion

Trial Locations (122)

112

Koo Foundation Sun Yat-Sen Cancer Center ( Site 2300), Taipei

704

National Cheng Kung University Hospital ( Site 2303), Tainan City

1122

Orszagos Onkologiai Intezet ( Site 1602), Budapest

4032

Debreceni Egyetem Klinikai Kozpont ( Site 1600), Debrecen

5000

Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 1601), Szolnok

6000

Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 1608), Kecskemét

7400

Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 1604), Kaposvár

7624

Pecsi Tudomanyegyetem Klinikai Kozpont ( Site 1607), Pécs

8900

Zala Megyei Szent Rafael Korhaz ( Site 1605), Zalaegerszeg

10002

Zhytomyr Regional Oncology Center ( Site 1515), Zhytomyr

10065

Memorial Sloan-Kettering Cancer Center ( Site 0156), New York

10408

National Cancer Center ( Site 2406), Goyang-si

10449

MacKay Memorial Hospital ( Site 2301), Taipei

11725

Memorial Sloan-Kettering Cancer Center at Commack ( Site 0160), Commack

13605

Seoul National University Bundang Hospital ( Site 2409), Seongnam-si

14004

Hospital Universitario Reina Sofia ( Site 0705), Córdoba

14029

Chernihiv Medical Center of Modern Oncology ( Site 1520), Chernihiv

14076

Centre Francois Baclesse ( Site 1012), Caen

16499

Ajou University Hospital ( Site 2407), Suwon

21565

Gachon University Gil Medical Center ( Site 2408), Incheon

23456

Virginia Oncology Associates ( Site 0164), Virginia Beach

23502

Virginia Oncology Associates ( Site 0153), Norfolk

23606

Virginia Oncology Associates ( Site 0163), Newport News

25030

CHU-Jean Minjoz ( Site 1013), Besançon

28027

Clinica Universitaria Navarra - Madrid ( Site 0700), Madrid

30177

Gynaekologisch-onkologische Praxis Hannover ( Site 1207), Hanover

30912

Georgia Cancer Center at Augusta University ( Site 0129), Augusta

31059

Institut Claudius Regaud IUCT Oncopole ( Site 1001), Toulouse

33098

Frauenklinik St. Louise ( Site 1216), Paderborn

33136

University of Miami Sylvester CC ( Site 0146), Miami

34070

Centre de Cancerologie du Grand Montpellier ( Site 1009), Montpellier

40225

Universitaetsklinikum AoeR Duesseldorf ( Site 1210), Düsseldorf

40447

China Medical University Hospital ( Site 2302), Taipei

41404

Kyungpook National University Chilgok Hospital ( Site 2402), Daegu

45136

Kliniken Essen-Mitte ( Site 1215), Essen

46015

Hospital General Arnau de Vilanova de Valencia ( Site 0706), Valencia

48202

Henry Ford Health System ( Site 0103), Detroit

49102

Dnipropetrovsk City Multidiscipline Clinical Hosp. 4 of DRC ( Site 1502), Dnipro

50048

CI Krivorizhskiy oncology dispensery ( Site 1504), Kryviy Rih

53111

Gynaekologisches Zentrum-Schwerpunkt Gyn. Onkologie ( Site 1205), Bonn

55407

Virginia Piper Cancer Institute ( Site 0157), Minneapolis

57085

CHR-METZ-THIONVILLE - Hopital de Mercy ( Site 1007), Metz

60637

University of Chicago ( Site 0159), Chicago

61024

Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 1508), Kharkiv

61070

Communal non profit enterprise Regional Clinical Oncology Center ( Site 1512), Kharkiv

61103

SI-Zaytsev institute of general and urgent surgery-NAMS ( Site 1518), Kharkiv

61231

Hochwaldkrankenhaus Bad Nauheim ( Site 1211), Bad Nauheim

63001

Centre Jean Perrin ( Site 1003), Clermont-Ferrand

63069

Sana Klinikum Offenbach Klinik fuer Gynakologie und Geburtshilfe ( Site 1206), Offenbach

68167

Universitaetsklinikum Mannheim GmbH ( Site 1213), Mannheim

69035

Medical center of the Limited Liability Company Yulis ( Site 1517), Zaporizhzhia

69104

Medical Centre LLC Oncolife ( Site 1510), Zaporizhzhya

69373

Centre Leon Berard ( Site 1018), Lyon

73120

Mercy Clinic Oncology and Hematology ( Site 0110), Oklahoma City

75010

Hôpital Saint-Louis ( Site 1025), Paris

76018

MI Precarpathian Clinical Oncology Center ( Site 1506), Ivano-Frankivsk

76038

Centre Henri Becquerel ( Site 1020), Rouen

76104

The Center For Cancer And Blood Disorders ( Site 0151), Fort Worth

77380

Renovatio Clinical ( Site 0117), The Woodlands

78130

Texas Oncology-New Braunfels ( Site 0168), New Braunfels

78217

Texas Oncology-San Antonio Northeast ( Site 0165), San Antonio

78240

Texas Oncology-San Antonio Medical Center ( Site 0158), San Antonio

78258

Texas Oncology - San Antonio Stone Oak ( Site 0166), San Antonio

80000

CHU Amiens Hopital Sud ( Site 1023), Amiens

80337

Klinik und Poliklinik fuer Frauenheilkunde und Geburtshilfe ( Site 1200), Munich

83301

Kaohsiung Chang Gung Memorial Hospital ( Site 2304), Kaohsiung City

84918

Institut Sainte Catherine ( Site 1026), Avignon

90404

John Wayne Cancer Institute ( Site 0111), Santa Monica

91054

Universitaetsklinikum Erlangen ( Site 1201), Erlangen

93940

Pacific Cancer Care ( Site 0142), Monterey

94158

UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0138), San Francisco

94805

Institut Gustave Roussy ( Site 1010), Villejuif

95403

St. Joseph Heritage Healthcare ( Site 0104), Santa Rosa

98902

YVMH dba Virginia Mason Memorial/North Star Lodge Cancer Center ( Site 0128), Yakima

230002

Oncomedica S.A. ( Site 0606), Montería

760032

Fundacion Valle del Lili ( Site 0602), Santiago de Cali

760042

Hemato Oncologos S.A. ( Site 0603), Santiago de Cali

1720430

IC La Serena Research ( Site 0511), La Serena

2520598

Oncocentro ( Site 0502), Viña del Mar

4780000

Centro Investigación del Cáncer James Lind ( Site 0510), Temuco

7500921

Fundacion Arturo Lopez Perez ( Site 0500), Santiago

8330032

Pontificia Universidad Catolica de Chile ( Site 0501), Santiago

02114

Massachusetts General Hospital ( Site 0155), Boston

07748

Memorial Sloan Kettering Cancer Center- Monmouth ( Site 0161), Middletown

07645

MSKCC-Bergen ( Site 0162), Montvale

M5G 2M9

Princess Margaret Cancer Centre ( Site 0005), Toronto

H7M 3L9

CSSS de Laval- Hopital de la Cite de la Sante ( Site 0011), Laval

H2X 3E4

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0003), Montreal

H3T 1E2

Jewish General Hospital ( Site 0010), Montreal

H4A 3J1

McGill University Health Centre ( Site 0002), Montreal

050030

Fundacion Colombiana de Cancerologia Clinica Vida ( Site 0601), Medellín

080020

Clinica de la Costa Ltda. ( Site 0600), Barranquilla

Organizacion Clinica Bonnadona-Prevenir S.A.S. ( Site 0609), Barranquilla

01307

Universitaetsklinikum Carl Gustav Carus ( Site 1203), Dresden

T12 DC4A

Cork University Hospital ( Site 0902), Cork

D04 YN63

St Vincents University Hospital ( Site 0900), Dublin

464-8681

Aichi Cancer Center Hospital ( Site 2202), Nagoya

663-8501

Hyogo College of Medicine Hospital ( Site 2203), Nishinomiya

960-1295

Fukushima Medical University Hospital ( Site 2201), Fukushima

730-8518

Hiroshima City Hiroshima Citizens Hospital ( Site 2204), Hiroshima

540-0006

National Hospital Organization - Osaka National Hospital - Institute For Clinical Research (Site 2200), Osaka

65-300

Pleszewskie Centrum Medyczne w Pleszewie Sp. z o.o. ( Site 1909), Pleszew

30-510

Pratia MCM Krakow ( Site 1919), Krakow

58-100

Regionalny Szpital Specjalistyczny Latawiec ( Site 1917), Swidnica

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (Site 1908), Warsaw

81-519

Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1913), Gdynia

44-102

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1912), Gliwice

03080

Seoul National University Hospital ( Site 2403), Seoul

03722

Severance Hospital Yonsei University Health System ( Site 2401), Seoul

05505

Asan Medical Center ( Site 2404), Seoul

06351

Samsung Medical Center ( Site 2405), Seoul

08023

Instituto Oncologico Baselga.Hospital Quiron. ( Site 0707), Barcelona

08035

Hospital Universitari Vall d Hebron ( Site 0701), Barcelona

08036

Hospital Clinic I Provincial de Barcelona ( Site 0702), Barcelona

04050

Medical Centre Consilium Medical ( Site 1514), Kyiv

03039

Medical Center Verum ( Site 1501), Kyiv

IV2 3UJ

Raigmore Hospital ( Site 0915), Inverness

FY3 8NR

Blackpool Victoria Hospital ( Site 0921), Blackpool

EC1M 6BQ

Barts Health NHS Trust ( Site 0912), London

BT47 6SB

North West Cancer Centre ( Site 0922), Londonderry

TA1 5DA

Musgrove Park Hospital ( Site 0918), Taunton

M20 4BX

The Christie NHS Foundation Trust ( Site 0914), Manchester

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY