A Study of Tazemetostat With Enzalutamide or Abiraterone/Prednisone in Participants With Advanced Prostate Cancer

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

102

Participants

Timeline

Start Date

November 18, 2019

Primary Completion Date

November 4, 2024

Study Completion Date

November 4, 2024

Conditions
Metastatic Prostate CancerMetastatic Castration-resistant Prostate Cancer
Interventions
DRUG

Tazemetostat

Tazemetostat (EPZ-6438) is a selective small-molecule inhibitor of the histone-lysine methyltransferase EZH2 gene

DRUG

Abiraterone/prednisone

1,000 mg (two 500 mg tablets or four 250 mg tablets) orally once daily in combination with prednisone 5 mg administered orally twice daily.

DRUG

Enzalutamide

enzalutamide 160 mg (four 40 mg capsules) orally once daily

Trial Locations (24)

10065

Memorial Sloan Kettering Cancer Center, New York

10461

Montefiore Einstein Center for Cancer Care, The Bronx

13210

Associated Medical Professionals of NY, PLLC - Urology, Syracuse

15232

University of Pittsburgh Medical Center - Hillman Cancer Center, Pittsburgh

34952

Hematology Oncology Associates of the Treasure Coast, Port Saint Lucie

37075

Urology Associates P.C., Hendersonville

37203

SCRI - Tennessee Oncology Nashville, Nashville

37404

SCRI - Tennessee Oncology Chattanooga, Chattanooga

37909

XCancer - Tennesee Cancer Specialists, Knoxville

60008

XCancer - Northwest Oncology and Hematology, Rolling Meadows

78229

Urology San Antonio, San Antonio

80211

The Urology Center Of Colorado, Denver

89169

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas

92123

Genesis Healthcare Partners, San Diego

02115

Dana Farber Cancer Institute, Boston

02215

Beth Israel Deaconess Medical Center, Boston

Unknown

Academisch Ziekenhuis Groeninge Campus Kennedylaan, Kortrijk

Hospital Universitario de Jerez de la Frontera, Jerez de la Frontera

Hospital de la Santa Creu i. Sant Pau, Barcelona

Hospital del Mar Parc de Salut Mar, Barcelona

Hospital Clinico San Carlos, Madrid

Hospital Universitario 12 de Octubre, Madrid

Hospital Universitario La Paz, Madrid

Clinica Universidad de Navarra, Pamplona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Epizyme, Inc.

INDUSTRY

NCT04179864 - A Study of Tazemetostat With Enzalutamide or Abiraterone/Prednisone in Participants With Advanced Prostate Cancer | Biotech Hunter | Biotech Hunter