Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial Infections

Enrolling by invitationOBSERVATIONAL
Enrollment

100

Participants

Timeline

Start Date

July 1, 2019

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
SepsisInfective EndocarditisPneumonia, Bacterial
Interventions
DIAGNOSTIC_TEST

Bood leukocyte subsets

Determination of blood leukocyte subpopulations, myeloid suppressor cells of various origins, type 2 congenital lymphoid cells, depleted T cells, CD45RA+ CD45RB+ CD62L-IRC, T-cell differentiation stages (naive - memory cells - effector - terminally differentiated effectors), B cells (CD5+ B1 cells, CD11c+ ABC, differentiation stages: immature - naive - isotype-unswitched memory cells - isotype-switched memory cells - plasmoblast)

DIAGNOSTIC_TEST

The cholesterol content of the cell membrane of T-cells and monocytes

The cholesterol content of the cell membrane of T-cells and monocytes with flow cytometry analysis

Trial Locations (1)

220114

The Republican Research and Practical Center for Epidemiology and Microbiology, Minsk

All Listed Sponsors
collaborator

Belarusian State Medical University

OTHER

lead

The Republican Research and Practical Center for Epidemiology and Microbiology

OTHER