176
Participants
Start Date
July 21, 2020
Primary Completion Date
May 30, 2027
Study Completion Date
August 31, 2027
Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization (ETV+CPC)
Since the early 1990s, ETV has become the main alternative to shunting for hydrocephalus. This procedure involves placing an endoscopic camera into the ventricles of the brain and creating a hole in the floor of the third ventricle to act as an internal bypass for obstructed CSF. The cauterization of choroid plexus (CPC) involves the use of a device to burn or cauterize tissue from the choroid plexus. The choroid plexus of the brain exists in the lateral ventricles, the third ventricle, and the fourth ventricle. Its main role is the production of CSF. The success of ETV alone is poor in infants, but when combined with CPC, improved results have been observed and ETV+CPC has become a safe viable option for these children.
Ventriculoperitoneal Shunt
The most common treatment for hydrocephalus has been the insertion of a ventriculoperitoneal shunt, which has been in popular use for over 50 years. This consists of silastic tubing attached to a valve mechanism that runs subcutaneously from the head to the abdomen. It is one of the most common procedures performed by pediatric neurosurgeons.
RECRUITING
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
ACTIVE_NOT_RECRUITING
The Pennsylvania State University, University Park
RECRUITING
Johns Hopkins Children's Center, Baltimore
ACTIVE_NOT_RECRUITING
Virginia Commonwealth University, Richmond
RECRUITING
Wolfson Children's Hospital, Jacksonville
RECRUITING
Arnold Palmer Hospital for Children, Orlando
RECRUITING
Children's of Alabama, Birmingham
RECRUITING
Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville
RECRUITING
Nationwide Children's Hospital, Columbus
NOT_YET_RECRUITING
Trustees of Indiana University, Indianapolis
RECRUITING
St. Louis Children's Hospital, St Louis
RECRUITING
Texas Children's Hospital, Houston
RECRUITING
Children's Hospital Colorado, Aurora
RECRUITING
Primary Children's Hospital, Salt Lake City
NOT_YET_RECRUITING
Phoenix Children's Hospital, Phoenix
RECRUITING
Children's Hospital of Los Angeles, Los Angeles
RECRUITING
Seattle Children's Hospital, Seattle
ACTIVE_NOT_RECRUITING
Yale University, New Haven
RECRUITING
Alberta Children's Hospital, Calgary
RECRUITING
British Columbia Children's Hospital, Vancouver
RECRUITING
The Hospital for Sick Children, Toronto
University of Alabama at Birmingham
OTHER
University of British Columbia
OTHER
University of Pittsburgh
OTHER
The Hospital for Sick Children
OTHER
Seattle Children's Hospital
OTHER
Vanderbilt University Medical Center
OTHER
Washington University School of Medicine
OTHER
Nationwide Children's Hospital
OTHER
Johns Hopkins University
OTHER
University of Calgary
OTHER
University of Colorado, Denver
OTHER
Children's Hospital Los Angeles
OTHER
National Institutes of Health (NIH)
NIH
Hydrocephalus Association
OTHER
Penn State University
OTHER
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Baylor College of Medicine
OTHER
University of Florida
OTHER
Orlando Health, Inc.
OTHER
Virginia Commonwealth University
OTHER
Trustees of Indiana University
UNKNOWN
University of Utah
OTHER