Combination Treatment (Talazoparib Plus Avelumab) for Stage IV or Recurrent Non-Squamous Non-Small Cell Lung Cancer With STK11 Gene Mutation (A LUNG-MAP Treatment Trial)

PHASE2CompletedINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

February 14, 2020

Primary Completion Date

November 24, 2021

Study Completion Date

May 1, 2024

Conditions
Advanced Lung Non-Squamous Non-Small Cell CarcinomaRecurrent Lung Non-Squamous Non-Small Cell CarcinomaStage IV Lung Cancer AJCC v8Stage IVA Lung Cancer AJCC v8Stage IVB Lung Cancer AJCC v8
Interventions
DRUG

Avelumab

Given IV

DRUG

Talazoparib

Given PO

DRUG

Talazoparib Tosylate

Given PO

Trial Locations (325)

13326

Mary Imogene Bassett Hospital, Cooperstown

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

14905

Arnot Ogden Medical Center/Falck Cancer Center, Elmira

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

17042

Sechler Family Cancer Center, Lebanon

17109

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17325

Adams Cancer Center, Gettysburg

17331

Cherry Tree Cancer Center, Hanover

17403

WellSpan Health-York Cancer Center, York

17522

Ephrata Cancer Center, Ephrata

17701

UPMC Susquehanna, Williamsport

19107

Thomas Jefferson University Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19140

Temple University Hospital, Philadelphia

19464

Pottstown Hospital, Pottstown

19901

Bayhealth Hospital Kent Campus, Dover

19963

Bayhealth Hospital Sussex Campus, Milford

21502

Western Maryland Regional Medical Center, Cumberland

22601

Shenandoah Oncology PC, Winchester

23230

Virginia Cancer Institute, Richmond

23235

VCU Massey Cancer Center at Stony Point, Richmond

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

23970

VCU Community Memorial Health Center, South Hill

24501

Centra Lynchburg Hematology-Oncology Clinic Inc, Lynchburg

25701

Edwards Comprehensive Cancer Center, Huntington

27705

Durham VA Medical Center, Durham

27710

Duke University Medical Center, Durham

28791

Margaret R Pardee Memorial Hospital, Hendersonville

29307

Prisma Health Cancer Institute - Spartanburg, Spartanburg

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29621

AnMed Health Cancer Center, Anderson

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30046

Northside Hospital - Gwinnett, Lawrenceville

30078

Suburban Hematology Oncology Associates - Snellville, Snellville

30096

Northside Hospital - Duluth, Duluth

30342

Northside Hospital, Atlanta

30517

Northeast Georgia Medical Center Braselton, Braselton

30607

University Cancer and Blood Center LLC, Athens

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

33331

Cleveland Clinic-Weston, Weston

33612

Moffitt Cancer Center, Tampa

36688

University of South Alabama Mitchell Cancer Institute, Mobile

39216

University of Mississippi Medical Center, Jackson

40509

Saint Joseph Hospital East, Lexington

40536

University of Kentucky/Markey Cancer Center, Lexington

43015

Delaware Health Center-Grady Cancer Center, Delaware

43055

Licking Memorial Hospital, Newark

43214

Columbus Oncology and Hematology Associates Inc, Columbus

43215

Grant Medical Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43228

Doctors Hospital, Columbus

43302

OhioHealth Marion General Hospital, Marion

43560

ProMedica Flower Hospital, Sylvania

43701

Genesis Healthcare System Cancer Care Center, Zanesville

44024

Geauga Hospital, Chardon

44035

Mercy Cancer Center-Elyria, Elyria

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

South Pointe Hospital, Warrensville Heights

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

UH Seidman Cancer Center at Landerbrook Health Center, Mayfield Heights

44129

University Hospitals Parma Medical Center, Parma

44130

UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights

44136

Cleveland Clinic Cancer Center Strongsville, Strongsville

44145

UH Seidman Cancer Center at Saint John Medical Center, Westlake

UHHS-Westlake Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44266

University Hospitals Portage Medical Center, Ravenna

44281

University Hospitals Sharon Health Center, Wadsworth

44691

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster

44870

North Coast Cancer Care, Sandusky

UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky

44906

Cleveland Clinic Cancer Center Mansfield, Mansfield

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45714

Strecker Cancer Center-Belpre, Belpre

45750

Marietta Memorial Hospital, Marietta

46158

Franciscan Health Mooresville, Mooresville

46237

Franciscan Health Indianapolis, Indianapolis

46526

Goshen Center for Cancer Care, Goshen

46601

Memorial Hospital of South Bend, South Bend

46845

Parkview Regional Medical Center, Fort Wayne

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48044

Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb

48054

Great Lakes Cancer Management Specialists-Doctors Park, East China Township

48093

Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren

Saint John Macomb-Oakland Hospital, Warren

48106

Saint Joseph Mercy Hospital, Ann Arbor

48114

Saint Joseph Mercy Brighton, Brighton

48118

IHA Hematology Oncology Consultants-Chelsea, Chelsea

Saint Joseph Mercy Chelsea, Chelsea

48154

Hope Cancer Clinic, Livonia

Saint Mary Mercy Hospital, Livonia

48188

IHA Hematology Oncology Consultants-Canton, Canton

Saint Joseph Mercy Canton, Canton

48197

IHA Hematology Oncology Consultants-Ann Arbor, Ypsilanti

48202

Henry Ford Hospital, Detroit

48236

Ascension Saint John Hospital, Detroit

Academic Hematology Oncology Specialists, Grosse Pointe Woods

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods

Michigan Breast Specialists-Grosse Pointe Woods, Grosse Pointe Woods

48309

Great Lakes Cancer Management Specialists-Rochester Hills, Rochester Hills

48503

Genesee Cancer and Blood Disease Treatment Center, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

48601

Ascension Saint Mary's Hospital, Saginaw

48604

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48764

Ascension Saint Joseph Hospital, Tawas City

48912

Sparrow Hospital, Lansing

49007

West Michigan Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49085

Marie Yeager Cancer Center, Saint Joseph

49201

Allegiance Health, Jackson

49444

Mercy Health Mercy Campus, Muskegon

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

Spectrum Health at Butterworth Campus, Grand Rapids

49519

Metro Health Hospital, Wyoming

49677

Spectrum Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

50010

Mary Greeley Medical Center, Ames

McFarland Clinic PC - Ames, Ames

50036

McFarland Clinic PC-Boone, Boone

50129

McFarland Clinic PC-Jefferson, Jefferson

50158

McFarland Clinic PC-Marshalltown, Marshalltown

50266

Mercy Medical Center-West Lakes, West Des Moines

50314

Medical Oncology and Hematology Associates-Laurel, Des Moines

Mercy Medical Center - Des Moines, Des Moines

50325

Medical Oncology and Hematology Associates-West Des Moines, Clive

Mercy Cancer Center-West Lakes, Clive

50501

McFarland Clinic PC-Trinity Cancer Center, Fort Dodge

50801

Greater Regional Medical Center, Creston

52803

Genesis Medical Center - East Campus, Davenport

52804

Genesis Cancer Care Institute, Davenport

52807

Iowa Cancer Specialists, Davenport

53022

Aurora Health Care Germantown Health Center, Germantown

53024

Aurora Cancer Care-Grafton, Grafton

53051

Froedtert Menomonee Falls Hospital, Menomonee Falls

53066

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53095

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53105

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53142

Aurora Cancer Care-Kenosha South, Kenosha

53209

Aurora Cancer Care-Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53406

Aurora Cancer Care-Racine, Racine

53792

University of Wisconsin Hospital and Clinics, Madison

54143

Aurora Bay Area Medical Group-Marinette, Marinette

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54311

Aurora BayCare Medical Center, Green Bay

54401

Aspirus Regional Cancer Center, Wausau

54409

Langlade Hospital and Cancer Center, Antigo

54451

Aspirus Medford Hospital, Medford

54494

Aspirus UW Cancer Center, Wisconsin Rapids

54601

Gundersen Lutheran Medical Center, La Crosse

54806

Duluth Clinic Ashland, Ashland

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55072

Essentia Health Sandstone, Sandstone

55415

Hennepin County Medical Center, Minneapolis

55417

Minneapolis VA Medical Center, Minneapolis

55746

Essentia Health Hibbing Clinic, Hibbing

55792

Essentia Health Virginia Clinic, Virginia

55805

Essentia Health Cancer Center, Duluth

56601

Sanford Joe Lueken Cancer Center, Bemidji

56636

Essentia Health - Deer River Clinic, Deer River

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

59715

Bozeman Deaconess Hospital, Bozeman

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

University of Chicago Medicine-Orland Park, Orland Park

60611

Northwestern University, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61282

Genesis Cancer Center - Silvis, Silvis

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61615

Illinois CancerCare-Peoria, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

63080

Missouri Baptist Sullivan Hospital, Sullivan

63110

Washington University School of Medicine, St Louis

63127

Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63129

Siteman Cancer Center-South County, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64108

Truman Medical Centers, Kansas City

64116

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

65804

Mercy Hospital Springfield, Springfield

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66606

University of Kansas Health System Saint Francis Campus, Topeka

67401

Salina Regional Health Center, Salina

67601

HaysMed University of Kansas Health System, Hays

70065

Ochsner Medical Center Kenner, Kenner

70121

Ochsner Medical Center Jefferson, New Orleans

70816

Medical Center of Baton Rouge, Baton Rouge

70836

Ochsner High Grove, Baton Rouge

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

79106

The Don and Sybil Harrington Cancer Center, Amarillo

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

80026

Good Samaritan Medical Center, Lafayette

80033

SCL Health Lutheran Medical Center, Wheat Ridge

80045

University of Colorado Hospital, Aurora

80113

Mountain Blue Cancer Care Center - Swedish, Englewood

Swedish Medical Center, Englewood

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

80206

National Jewish Health-Main Campus, Denver

80218

Rocky Mountain Cancer Centers-Midtown, Denver

SCL Health Saint Joseph Hospital, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

80260

National Jewish Health-Northern Hematology Oncology, Thornton

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80401

National Jewish Health-Western Hematology Oncology, Golden

80539

McKee Medical Center, Loveland

80631

North Colorado Medical Center, Greeley

83301

Saint Luke's Mountain States Tumor Institute-Twin Falls, Twin Falls

83619

Saint Luke's Mountain States Tumor Institute - Fruitland, Fruitland

83642

Saint Luke's Mountain States Tumor Institute - Meridian, Meridian

83686

Saint Luke's Mountain States Tumor Institute - Nampa, Nampa

83712

Saint Luke's Mountain States Tumor Institute, Boise

83814

Kootenai Medical Center, Coeur d'Alene

83854

Kootenai Cancer Center, Post Falls

83864

Kootenai Cancer Clinic, Sandpoint

87102

University of New Mexico Cancer Center, Albuquerque

87110

Presbyterian Kaseman Hospital, Albuquerque

87124

Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho

88011

Memorial Medical Center - Las Cruces, Las Cruces

89102

OptumCare Cancer Care at Oakey, Las Vegas

89148

OptumCare Cancer Care at Fort Apache, Las Vegas

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90034

Kaiser Permanente-Cadillac, Los Angeles

90602

Presbyterian Intercommunity Hospital, Whittier

90706

Kaiser Permanente-Bellflower, Bellflower

90710

Kaiser Permanente - Harbor City, Harbor City

91367

Kaiser Permanente-Woodland Hills, Woodland Hills

91402

Kaiser Permanente - Panorama City, Panorama City

91706

Kaiser Permanente-Baldwin Park, Baldwin Park

92078

Kaiser Permanente-San Marcos, San Marcos

92120

Kaiser Permanente-San Diego Zion, San Diego

92335

Kaiser Permanente-Fontana, Fontana

92505

Kaiser Permanente-Riverside, Riverside

92618

Kaiser Permanente-Irvine, Irvine

92806

Kaiser Permanente-Anaheim, Anaheim

93720

Kaiser Permanente-Fresno, Fresno

94040

Palo Alto Medical Foundation-Camino Division, Mountain View

94080

Kaiser Permanente-South San Francisco, South San Francisco

94086

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

California Pacific Medical Center-Pacific Campus, San Francisco

Kaiser Permanente-San Francisco, San Francisco

94301

Palo Alto Medical Foundation Health Care, Palo Alto

94538

Palo Alto Medical Foundation-Fremont, Fremont

94577

Kaiser Permanente San Leandro, San Leandro

94589

Kaiser Permanente-Vallejo, Vallejo

Sutter Solano Medical Center/Cancer Center, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente-Oakland, Oakland

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

94903

Kaiser San Rafael-Gallinas, San Rafael

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95065

Palo Alto Medical Foundation-Santa Cruz, Santa Cruz

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95661

Kaiser Permanente-Roseville, Roseville

95814

Kaiser Permanente Downtown Commons, Sacramento

95816

Sutter Medical Center Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

96701

Hawaii Cancer Care - Savio, ‘Aiea

96813

Hawaii Cancer Care Inc-POB II, Honolulu

Queen's Cancer Cenrer - POB I, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

96817

Queen's Cancer Center - Kuakini, Honolulu

97227

Kaiser Permanente Northwest, Portland

97301

Salem Hospital, Salem

98368

Jefferson Healthcare, Port Townsend

06520

Yale University, New Haven

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06516

Veterans Affairs Connecticut Healthcare System-West Haven Campus, West Haven

01805

Lahey Hospital and Medical Center, Burlington

01655

UMass Memorial Medical Center - University Campus, Worcester

03301

New Hampshire Oncology Hematology PA-Concord, Concord

03103

Solinsky Center for Cancer Care, Manchester

07740

Monmouth Medical Center, Long Branch

08057

Virtua Samson Cancer Center, Moorestown

08876

Robert Wood Johnson University Hospital Somerset, Somerville

08043

Virtua Voorhees, Voorhees Township

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

54235-1495

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

SWOG Cancer Research Network

NETWORK

NCT04173507 - Combination Treatment (Talazoparib Plus Avelumab) for Stage IV or Recurrent Non-Squamous Non-Small Cell Lung Cancer With STK11 Gene Mutation (A LUNG-MAP Treatment Trial) | Biotech Hunter | Biotech Hunter