A Study of Erdafitinib Versus Investigator Choice of Intravesical Chemotherapy in Participants Who Received Bacillus Calmette-Guérin (BCG) and Recurred With High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC)

PHASE2CompletedINTERVENTIONAL
Enrollment

107

Participants

Timeline

Start Date

February 28, 2020

Primary Completion Date

July 12, 2024

Study Completion Date

February 27, 2025

Conditions
Urinary Bladder Neoplasms
Interventions
DRUG

Erdafitinib

Participants will receive erdafitinib orally beginning on Cycle 1 Day 1 until 2 years of treatment have been completed, disease recurrence, intolerable toxicity, withdrawal of consent, a decision by the investigator to discontinue treatment, or study termination, whichever occurs first. Each cycle is of 28 days.

DRUG

Investigator Choice (Gemcitabine)

Investigator's Choice treatment will be given once weekly for at least 4 doses of induction followed by monthly maintenance for at least 6 months.

DRUG

Investigator Choice (Mitomycin C)

Investigator's Choice treatment will be given once weekly for at least 4 doses of induction followed by monthly maintenance for at least 6 months.

Trial Locations (150)

2010

St Vincent s Hospital Sydney, Darlinghurst

2109

Macquarie University, Macquarie University

3000

Peter MacCallum Cancer Centre, Melbourne

UZ Leuven, Leuven

4000

CHU Sart-Tilman, Liège

5000

Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica, Córdoba

5042

Flinders Medical Centre, Bedford Park

8036

Hosp Clinic de Barcelona, Barcelona

8800

Algemeen Ziekenhuis Delta, Roeselare

9000

AZ Maria Middelares, Ghent

10002

National Taiwan University Hospital, Taipei

10016

NYU Langone Health, New York

10408

National Cancer Center, Goyang-si

10461

Montefiore Medical Center, The Bronx

11100

Ospedale Regionale Umberto Parini, Aosta

11217

Taipei Veterans General Hospital, Taipei

12208

Albany Medical College, Albany

13273

Institut Paoli Calmettes, Marseille

14132

Great Lakes Physician PC d/b/a Western New York Urology Associates, Sanborn

15232

University of Pittsburgh Medical Center - Cancer Centers, Pittsburgh

19004

MidLantic Urology, Bala-Cynwyd

20132

IRCCS Ospedale San Raffaele, Milan

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

23538

Universitatsklinikum Schleswig Holstein Campus Lubeck, Lübeck

28034

Hosp. Univ. Ramon Y Cajal, Madrid

28041

Hosp. Univ. 12 de Octubre, Madrid

28046

Hosp. Univ. La Paz, Madrid

28204

Levine Cancer Institute, Charlotte

30322

Emory University Winship Cancer Institute, Atlanta

31000

Institut Universitaire du Cancer Toulouse Oncopole, Toulouse

33016

Urological Research Network, Hialeah

33076

Hopital Pellegrin CHU Bordeaux, Bordeaux

33305

Chang Gung Memorial Hospital- Linkou, Taoyuan

35033

Chu Rennes Hopital Pontchaillou, Rennes

35760

CHP Saint Gregoire, Saint-Grégoire

37126

Azienda Ospedaliera Universitaria Integrata Verona, Verona

37209

Urology Associates, Nashville

39008

Hosp. Univ. Marques de Valdecilla, Santander

40447

China Medical University Hospital, Taichung

40705

Taichung Veterans General Hospital, Taichung

41404

Kyungpook National University Chilgok Hospital, Daegu

42016

Ospedale Civile di Guastalla, Guastalla

43221

The Ohio State University- James Cancer Hospital, Columbus

44625

Klinikum Herne - Urologie, Herne

45212

The Urology Group, Cincinnati

45468

Praxisklinik Urologie Rhein/Ruhr - Germany, Mülheim

46009

Instituto Valenciano de Oncologia, Valencia

47169

Urologicum Duisburg, Duisburg

48149

Universitaetsklinikum Muenster, Münster

49241

Pusan National University Hospital, Busan

50389

CUROS - Uberörtliche urologische Gemeinschaftspraxis, Wesseling

53226

Medical College of Wisconsin Froedtert Hospital, Milwaukee

54519

Centre Hospitalier Universitaire de Nancy - Hôpital Central, Vandœuvre-lès-Nancy

58128

Chonnam National University Hwasun Hospital, Jeollanam-do

59037

Hopital Huriez, Lille

60611

Northwestern University, Chicago

62100

UOC Oncologia Ospedale Provinciale di Macerata, Macerata

62702

Simmons Cancer Institute, Springfield

63000

CHU Gabriel-Montpied, Clermont-Ferrand

66205

University of Kansas, Westwood

69437

Hôpital Edouard Herriot, Lyon

70021

Ente Ecclesiastico Ospedale Generale Regionale F. Miulli, Acquaviva delle Fonti

72622

Studienpraxis Urologie Drs. Feyerabend, Nürtingen

73100

Azienda Ospedaliera ''Vito Fazzi'', Lecce

75013

Hôpital Universitaire Pitié-Salpêtrière, Paris

75020

Groupe Hospitalier Diaconesses Croix Saint Simon, Paris

75390

UT Southwestern Medical Center, Dallas

75877

Hopital Bichat Claude Bernard, Paris

76031

Hopital Charles Nicolle, Rouen

80138

Fondazione G Pascale Istituto Nazionale Tumori IRCCS, Napoli

80211

The Urology Center of Colorado, Denver

80756

Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung City

81675

Klinikum rechts der Isar - III. Med. Klinik und Poliklinik, München

85741

Urological Associates of Southern Arizona, P.C., Tucson

86021

CHU De Poitiers, Poitiers

90015

Fondazione Istituto G. Giglio, Cefalù

90033

USC Institute of Urology, Los Angeles

90491

MVZ Urologie 24 gGmbH, Nuremberg

94800

Gustave Roussy, Villejuif

97239

Oregon Health And Science University, Portland

98008

University of Washington, Seattle

110085

Rajiv Gandhi Cancer Institute & Research Centre, Delhi

200032

Fudan University Shanghai Cancer Center, Shanghai

200240

Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai

210008

Nanjing Drum Tower Hospital, Nanjing

226003

King Georges Medical University, Lucknow

387001

Muljibhai Patel Urological Hospital, Nadiād

411040

CIMET s Inamdar Multispeciality Hospital, Pune

430030

Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology, Wuhan

560027

Health Care Global Enterprises pvt Ltd, Bangalore

625107

Meenakshi Mission Hospital and Research Center, Madurai

C1419AHN

Sociedade Beneficente de Senhoras Hospital Sirio Libanes, Buenos Aires

C1431FWN

CEMIC Saavedra, Buenos Aires

Unknown

Hospital Britanico de Buenos Aires, Buenos Aires

C1199ABB

Hospital Italiano de Buenos Aires, Ciudad Autonoma de

X5000KPH

Centro Urologico Profesor Bengio, Córdoba

XX5016KEH

Hospital Privado de Cordoba, Córdoba

81520 060

Liga Paranaense de Combate ao Cancer, Curitiba

60135-237

Oncocentro Ceará, Fortaleza

74605-070

Associacao de Combate ao Cancer em Goias - Hospital de Cancer Araujo Jorge, Goiânia

59075-740

Liga Norte Riograndense Contra O Cancer, Natal

90050-170

Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre

91350 200

Hospital Nossa Senhora da Conceicao S A, Porto Alegre

50070-550

Instituto de Medicina Integral Professor Fernando Figueira, Recife

14048-900

Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP, Ribeirão Preto

22250 905

Oncoclinicas Rio de Janeiro S A, Rio de Janeiro

22775 001

Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI), Rio de Janeiro

09060-650

CEPHO Centro de Estudos e Pesquisa de Hematologia e Oncologia, Santo André

01246 000

Fundacao Faculdade de Medicina Instituto do Cancer do Estado de Sao Paulo, São Paulo

01308 901

Sociedade Beneficente de Senhoras Hospital Sirio Libanes, São Paulo

04039-004

Instituto de Assistencia Medica ao Servidor Publico Estadual IAMSPE, São Paulo

656 91

Fakultni nemocnice u sv. Anny v Brne, Brno

460 63

Krajská nemocnice Liberec, Liberec

128 08

Vseobecna fakultni nemocnice v Praze, Prague

150 06

Fakultni nemocnice v Motole, Prague

00189

Azienda Ospedaliera Sant Andrea, Roma

113 8431

Juntendo University Hospital, Bunkyō City

113 8519

Tokyo Medical and Dental University Hospital, Bunkyō City

289-2511

Asahi General Hospital, Chiba

040 8611

Hakodate Goryoukaku Hospital, Hakodate

350-1298

Saitama Medical University International Medical Center, Hidaka

317-0077

Hitachi General Hospital, Hitachi

216 8511

St Marianna University Hospital, Kanagawa

466 8560

Nagoya University Hospital, Nagoya

591-8025

JOHAS Osaka Rosai Hospital, Osaka

373 8550

Gunma Prefectural Cancer Center, Ōta-ku

569-8686

Osaka Medical and Pharmaceutical University Hospital, Takatsuki

105-8470

Toranomon Hospital, Tokyo

135 8550

The Cancer Institute Hospital of JFCR, Tokyo

470-1192

Fujita Health University Hospital, Toyoake

305 8576

University of Tsukuba Hospital, Tsukuba

232 0024

Yokohama City University Medical Center, Yokohama

80 214

Uniwersyteckie Centrum Kliniczne, Gdansk

30 727

Pratia MCM Krakow, Krakow

35-055

Uniwersytecki Szpital Kliniczny im. Fryderyka Chopina w Rzeszowie, Rzeszów

70-111

Samodzielny Publiczny Szpital Kliniczny nr 2 PUM, Szczecin

02 798

Medical Concierge Centrum Medyczne, Warsaw

02-473

City Clinic Sp. z o.o., Warsaw

50-556

Uniwersytecki Szpital Kliniczny, Wroclaw

361-711

Chungbuk National University Hospital, Cheongju-si

02841

Korea University Anam Hospital, Seoul

03080

Seoul National University Hospital, Seoul

03181

Kangbuk Samsung Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

06351

Samsung Medical Center, Seoul

08025

Fund. Puigvert, Barcelona

08208

Corporacio Sanitari Parc Tauli, Sabadell

M20 4BX

The Christie NHS Foundation Trust Christie Hospital, Manchester

S10 2JF

Universirty of Sheffield Teaching Hospitals NHS Trust, Sheffield

SG1 4AB

Lister Hospital, Stevenage

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY

NCT04172675 - A Study of Erdafitinib Versus Investigator Choice of Intravesical Chemotherapy in Participants Who Received Bacillus Calmette-Guérin (BCG) and Recurred With High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) | Biotech Hunter | Biotech Hunter