Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

92

Participants

Timeline

Start Date

January 11, 2021

Primary Completion Date

August 1, 2026

Study Completion Date

August 1, 2026

Conditions
Locally Advanced Pancreatic AdenocarcinomaStage III Pancreatic Cancer AJCC v8
Interventions
PROCEDURE

Biopsy Procedure

Undergo tissue collection

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT

RADIATION

Hypofractionated Radiation Therapy

Undergo hypofractionated radiation therapy

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Peposertib

Given PO

OTHER

Placebo Administration

Given PO

Trial Locations (42)

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10029

RECRUITING

Mount Sinai Hospital, New York

10065

RECRUITING

NYP/Weill Cornell Medical Center, New York

10461

RECRUITING

Montefiore Medical Center-Einstein Campus, The Bronx

10467

RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

14263

ACTIVE_NOT_RECRUITING

Roswell Park Cancer Institute, Buffalo

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

20016

RECRUITING

Sibley Memorial Hospital, Washington D.C.

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

27012

ACTIVE_NOT_RECRUITING

Wake Forest University at Clemmons, Clemmons

27157

ACTIVE_NOT_RECRUITING

Wake Forest University Health Sciences, Winston-Salem

28659

ACTIVE_NOT_RECRUITING

Wake Forest Baptist Health - Wilkes Medical Center, Wilkesboro

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

40536

WITHDRAWN

University of Kentucky/Markey Cancer Center, Lexington

48201

SUSPENDED

Wayne State University/Karmanos Cancer Institute, Detroit

48334

SUSPENDED

Weisberg Cancer Treatment Center, Farmington Hills

60611

ACTIVE_NOT_RECRUITING

Northwestern University, Chicago

64064

RECRUITING

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64108

RECRUITING

University Health Truman Medical Center, Kansas City

64116

SUSPENDED

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

RECRUITING

University of Kansas Cancer Center - North, Kansas City

66044

RECRUITING

Lawrence Memorial Hospital, Lawrence

66061

RECRUITING

The University of Kansas Cancer Center - Olathe, Olathe

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Clinical Research Center, Fairway

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

RECRUITING

University of Kansas Cancer Center-Overland Park, Overland Park

66606

RECRUITING

University of Kansas Health System Saint Francis Campus, Topeka

66762

SUSPENDED

Mercy Hospital Pittsburg, Pittsburg

67401

RECRUITING

Salina Regional Health Center, Salina

67601

RECRUITING

HaysMed, Hays

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92618

RECRUITING

City of Hope at Irvine Lennar, Irvine

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

03756

ACTIVE_NOT_RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07039

SUSPENDED

Saint Barnabas Medical Center, Livingston

07740

RECRUITING

Monmouth Medical Center, Long Branch

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH