Development of a Swiss Surveillance Database for Molecular Epidemiology of Hypervirulent and Multi-drug Resistant Pathogens

RecruitingOBSERVATIONAL
Enrollment

10,000

Participants

Timeline

Start Date

September 30, 2019

Primary Completion Date

December 31, 2029

Study Completion Date

December 31, 2029

Conditions
Multiresistant Bacterial PathogensVirulent Bacterial Pathogens
Interventions
DIAGNOSTIC_TEST

Analysis of Bacterial Genome

genome assembly; prediction of sequence type (MLST); core genome MLST tree to rapidly compare strains within a project; core genome single nucleotide polymorphism (SNP) tree to compare all Swiss Pathogen Surveillance Platform (SPSP) strains belonging to a same species; whole genome SNP tree to compare all SPSP strains within the same species and ST;; prediction of resistance and virulence factors within pathogen submitted genomes; time trees and calculation of transmission rates, including basic reproduction number; analysis of classical epidemiological data with advanced statistical methods including machine learning.

Trial Locations (5)

1011

RECRUITING

University Hospital Lausanne CHUV, Lausanne

1205

RECRUITING

University Hospital Geneva, Geneva

3012

RECRUITING

University of Bern, Bern

4031

RECRUITING

University Hospital Basel, Basel

8057

RECRUITING

University of Zurich, Zurich

All Listed Sponsors
collaborator

Swiss National Science Foundation

OTHER

lead

University Hospital, Basel, Switzerland

OTHER