Long-term Extension Study of Zanubrutinib (BGB-3111) Regimens in Participants With B-cell Malignancies

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

955

Participants

Timeline

Start Date

January 16, 2020

Primary Completion Date

November 30, 2027

Study Completion Date

December 31, 2028

Conditions
B-cell Malignancies
Interventions
DRUG

Zanubrutinib

Participants will receive zanubrutinib at a dose of 160 mg twice daily (for a total daily dose of 320 mg), or the last dose level received in the BeiGene parent study.

DRUG

Tislelizumab

Patients in Australia who participated in a parent study that involved combination therapy of zanubrutinib and tislelizumab will receive tislelizumab at a dose of 200mg every 3 weeks..

Trial Locations (152)

1023

Auckland City Hospital, Auckland

2025

Aotearoa Clinical Trials, Auckland

2065

Royal North Shore Hospital, St Leonards

2139

Concord Repatriation General Hospital, Concord

2145

Westmead Hospital, Westmead

2217

St George Hospital, Kogarah

2298

Calvary Mater Newcastle, Waratah

2606

Paratus Clinical Research Woden, Canberra

2640

Border Medical Oncology, East Albury

3000

Peter Maccallum Cancer Centre, Melbourne

3004

The Alfred Hospital, Melbourne

3065

St Vincents Hospital Melbourne, Fitzroy

3084

Austin Health, Heidelberg

3112

Tauranga Hospital, Tauranga

3128

Box Hill Hospital, Box Hill

3144

Cabrini Hospital Malvern, Malvern

3168

Monash Health, Clayton

3199

Peninsula Private Hospital, Frankston

3204

Waikato Hospital, Hamilton Waikato

3220

Barwon Health the Geelong Hospital, Geelong

4066

Icon Cancer Centre Wesley, Auchenflower

4102

Princess Alexandra Hospital, Brisbane

4120

Brisbane Clinic For Lymphoma, Greenslopes

4224

John Flynn Private Hospital, Tugun

5000

Royal Adelaide Hospital, Adelaide

5037

Icon Cancer Centre Kurralta Park, Kurralta Park

5042

Flinders Medical Centre, Bedford PK

6000

Royal Perth Hospital, Perth

6009

Sir Charles Gairdner Hospital, Nedlands

6021

Wellington Regional Hospital (Ccdhb), Wellington

7000

Royal Hobart Hospital, Hobart

8011

Christchurch Hospital, Christchurch

8036

Hospital Clinic de Barcelona, Barcelona

10000

Vseobecna Fakultni Nemocnice V Praze, Prague

10034

University Hospital Vinohrady Hematology Department, Prague

10126

Azienda Ospedaliera Citta Della Salute E Della Scienza Di Torino, Torino

10408

National Cancer Center, Goyang-si

11528

General Hospital of Athens Alexandra, Athens

11590

Clinical Research Alliance, Inc, Westbury

15748

Interhem Opieka Szpitalna, Bialystok

17007

Ico Girona, Girona

20162

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan

24014

Oncology and Hematology Associates of Southwest Virginia, Inc, Roanoke

27100

Irccs Policlinico San Matteo, Universita Degli Studi Di Pavi, Pavia

27705

Duke University Hospital, Durham

28034

Hospital Universitario Ramon Y Cajal, Madrid

28100

Aou Maggiore Della Carita, Novara

33076

Centre de Lutte Contre Le Cancer Institut Bergonie, Bordeaux

33100

Aou Santa Maria Della Misericordia Di Udine, Udine

33705

Scri Florida Cancer Specialists North, St. Petersburg

33916

Florida Cancer Specialists Fort Myers, Fort Myers

37000

Chu Tours Hopital Bretonneau, Tours

37007

Hospital Universitario de Salamanca, Salamanca

37205

Tennessee Oncology, Nashville

37404

Scri Tennessee Oncology Chattanooga, Chattanooga

39401

Forrest General Hospital Cancer Center, Hattiesburg

40138

Policlinico Sorsola Malpighi, Aou Di Bologna, Bologna

41124

Universita Degli Studi Di Modena Azienda Ospedaliere Policlinco, Modena

45004

Hospital Universitario de Toledo, Toledo

47014

Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori Irst, Meldola

47392

Inje University Busan Paik Hospital, Busan

48109

University of Michigan Health System, Ann Arbor

48121

Unita Di Ematologia, Dipartimento Di Ematologia Ed Oncologia, Ravenna

49201

Dong A University Hospital, Busan

50005

Fakultni Nemocnice Hradec Kralove, Hradec Králové

55905

Mayo Clinic Rochester, Rochester

59100

Namik Kemal University, Tekirdağ

62500

Fakultni Nemocnice Brno, Brno

68198

University of Nebraska Medical Center, Omaha

69495

Chu Hopital Lyon Sud, PierreBenite

72037

Centre Hospitalier Le Mans, Le Mans

72205

Carti Cancer Center, Little Rock

72488

Srh Kliniken Landkreis Sigmaringen, Sigmaringen

75010

Hopital Saint Louis, Paris

77900

Fakultni Nemocnice Olomouc, Olomouc

78240

Texas Oncology San Antonio Medical Center Usor, San Antonio

80112

Rocky Mountain Cancer Centers Centennial, Centennial

80218

Colorado Blood Cancer Institute, Denver

85234

Banner Md Anderson Cancer Center, Gilbert

85925

Centre Hospitalier Departemental de Vendee, La Roche-sur-Yon

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

97239

Oregon Health and Science University, Portland

97401

Oncology Associates of Oregon Willamette Valley Cancer Center, Eugene

98185

University of Washington Seattle Cancer Alliance, Seattle

99208

Medical Oncology Associates, Spokane

100000

Peking University Third Hospital, Beijing

100044

Peking University Peoples Hospital, Beijing

100142

Beijing Cancer Hospital, Beijing

100730

Peking Union Medical College Hospital, Beijing

110004

Shengjing Hospital of China Medical University, Shenyang

130021

The First Hospital of Jilin University, Changchun

150000

Harbin Medical University Cancer Hospital, Harbin

200000

Fudan University Shanghai Cancer Center, Shanghai

200092

Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai

210029

Jiangsu Province Hospital, Nanjing

221000

The Affiliated Hospital of Xuzhou Medical University, Xuzhou

300020

Institute of Hematology and Hospital of Blood Disease, Tianjin

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310003

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

350001

Fujian Medical University Union Hospital, Fuzhou

362000

Quanzhou First Affliated Hospital of Fujian Medical University, Quanzhou

430022

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430030

Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan

450000

Henan Cancer Hospital, Zhengzhou

510080

Guangdong Provincial Peoples Hospital, Guangzhou

510515

Nanfang Hospital of Southern Medical University, Guangzhou

610041

West China Hospital, Sichuan University, Chengdu

02215

Dana Farber Cancer Institute, Boston

07932

Summit Medical Group, Florham Park

07960

Atlantic Health System, Morristown

76104-2150

Texas Oncology Fort Worth Cancer Center, Fort Worth

77030-4009

The University of Texas Md Anderson Cancer Center, Houston

708 00

Fakultni Nemocnice Ostrava, Ostrava

00168

Fondazione Policlinico Universitario Agostino Gemelli, Roma

05100

Azienda Ospedaliera S Maria Di Terni, Terni

441-8570

Toyohashi Municipal Hospital, Toyohashi

830-0011

Kurume University Hospital, Kurume

003-0804

National Hospital Organization Hokkaido Cancer Center, Sapporo

064-0804

Aiiku Hospital, Sapporo

1105 AZ

Amsterdam Umc Amc, Amsterdam

6525 GA

Albert Schweitzer Ziekenhuis, Nijmegen

3584 CX

Universitair Medisch Centrum Utrecht, Utrecht

0622

North Shore Hospital, Takapuna

36-200

Szpital Specjalist W Brzozowie,Podkarpacki Osrodek Onkologiczny, Brzozów

85-168

Szpital Uniwersytecki Nr Im Dr Jana Biziela, Bydgoszcz

41-500

Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich, Chorzów

80-952

Uniwersyteckie Centrum Kliniczne, Gdansk

80-219

Copernicus Podmiot Leczniczy Sp Z Oo Wojewodzkie Centrum Onkologii, Gdask

30-510

Malopolskie Centrum Medyczne Sc, Krakow

93-510

Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz

60-185

Centrum Medyczne Pratia Poznan, Skorzewo Poznan

03722

Severance Hospital Yonsei University Health System, Seoul

135-740

Samsung Medical Center Hematology Oncology, Seoul

08025

Hospital de La Santa Creu I Sant Pau, Barcelona

08035

Hospital Universitario Vall Dhebron, Barcelona

08916

Ico Hug Trias I Pujol, Barcelona

221 85

Skanes Universitetssjukhus I Lund, Lund

171 76

Karolinska Universitetssjukhuset Solna, Stockholm

AB25 2ZN

Nhs Grampian Ppds, Aberdeen

B9 5SS

Birmingham Heartlands Hospital, Birmingham

BH7 7DW

The Royal Bournemouth and Christchurch Hospitals Nhs Foundation, Bournemouth

CT1 3NG

Kent and Canterbury Hospital, Canterbury

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

M20 4BX

The Christie Hospital, Greater Manchester

OX3 7LE

Churchill Hospital Oxford University Hospital Nhs Trust, Headington

LS9 7LP

St Jamess Institute of Oncology, Leeds

EC1A 7BE

Barts Health Nhs Trust, London

NW1 2PG

University College Hospital, London

NG51PB

Nottingham University Hospitals Nhs Trust, Nottingham

PL6 8DH

Plymouth Hospitals Nhs Trust, Plymouth

SO16 6YD

Southampton General Hospital, Southampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY