Effect of Intraoperative Dynamic Compliance Guided Individualized Positive End-expiratory Pressure on Postoperative Atelectasis After Laparoscopic Bariatric Surgery

NACompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

December 16, 2019

Primary Completion Date

September 30, 2020

Study Completion Date

July 19, 2021

Conditions
Postoperative Atelectasis
Interventions
PROCEDURE

Dynamic compliance guided individualized positive end-expiratory pressure titration strategy

"Basic ventilation: Volume-controlled ventilation (VCV) mode with positive end-expiratory pressure (PEEP) of 8cm H2O after induction of anesthesia,~Recruitment maneuver (RM): Pressure-controlled ventilation (PCV) mode increasing PEEP from 10 to 25cmH2O in step of 5cmH2O per 30s.~PEEP-titration maneuver: ventilation parameters reset as basic ventilation with PEEP still 25cmH2O.Decrease PEEP to 5cmH2O in step of 2cmH2O per 10 respiratory cycles to confirm the highest dynamic lung compliance (Cdy).~After titration: A new RM will be performed and the final PEEP will be the one related to highest Cdy plus 2cm H2O.~Randomized after the second RM. Individualized PEEP arm: maintain individualized PEEP; PEEP8 arm: maintain a fixed PEEP of 8cm H2O.~VCV with other ventilation parameters the same as basic ventilation until extubation .~After discharged from postoperative anesthesia care unit (60 to 90 minutes after extubation): chest CT ."

Trial Locations (1)

Unknown

Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University, Xuzhou

All Listed Sponsors
lead

Xuzhou Medical University

OTHER

NCT04169607 - Effect of Intraoperative Dynamic Compliance Guided Individualized Positive End-expiratory Pressure on Postoperative Atelectasis After Laparoscopic Bariatric Surgery | Biotech Hunter | Biotech Hunter