Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion

PHASE3RecruitingINTERVENTIONAL
Enrollment

270

Participants

Timeline

Start Date

September 20, 2020

Primary Completion Date

December 20, 2025

Study Completion Date

December 20, 2025

Conditions
SepsisCardiomyopathiesHypoperfusionLeft Ventricular Systolic Dysfunction
Interventions
DRUG

Placebos

Placebo will initially be started at a dose of 2.5 µg/kg/min and subsequently titrated using incremental steps (predefined durations) of 2.5 µg/kg/min, up to a maximal dose of 10 µg/kg/min. Dose adaptation will be left at the discretion of attending physician.

DRUG

Dobutamine

Dobutamine will initially be started at a dose of 2.5 µg/kg/min and subsequently titrated using incremental steps (predefined durations) of 2.5 µg/kg/min, up to a maximal dose of 10 µg/kg/min. Dose adaptation will be left at the discretion of attending physician.

Trial Locations (27)

16959

TERMINATED

Angouleme Hospital, Angoulême

19100

RECRUITING

CH de Brive, Brive-la-Gaillarde

21033

TERMINATED

Dijon university hospital, Dijon

29200

RECRUITING

University Hospital, Brest

34295

TERMINATED

Montpellier University Hospital, Montpellier

37044

RECRUITING

CHU Tours - Service de Réanimation, Tours

38043

RECRUITING

CHU de Grenoble-Alpes, La Tronche

47067

TERMINATED

CHU Orléans - service de Réanimation, Orléans

54511

WITHDRAWN

CHU de Nancy, Nancy

59045

TERMINATED

Lille University Hospital, Lille

67000

TERMINATED

CHU Strasbourg - service de Réanimation, Strasbourg

67500

RECRUITING

CH d'Haguenau, Haguenau

72000

RECRUITING

Le Mans Hospital, Le Mans

75010

RECRUITING

Aphp - Ambroise Paré, Paris

75014

WITHDRAWN

Hôpital Cochin - service de Réanimation, Paris

80000

WITHDRAWN

University Hospital, Amiens

83000

RECRUITING

CH de Toulon, Toulon

86000

RECRUITING

Poitiers University Hospital, Poitiers

87042

RECRUITING

Limoges University Hospital, Limoges

94010

TERMINATED

Aphp - Henri Mondor, Créteil

95107

RECRUITING

Argenteuil Hospital, Argenteuil

Unknown

RECRUITING

CH de Bethune, Béthune

RECRUITING

CH de Cannes, Cannes

RECRUITING

CH de Vendée, La Roche-sur-Yon

RECRUITING

CH de Versailles, Le Chesnay

RECRUITING

HCL, Lyon

06202

RECRUITING

Nice University Hospital, Nice

All Listed Sponsors
collaborator

Centre d'Investigation Clinique 1415

UNKNOWN

lead

University Hospital, Limoges

OTHER