KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

RecruitingOBSERVATIONAL
Enrollment

1,065

Participants

Timeline

Start Date

December 19, 2019

Primary Completion Date

February 13, 2032

Study Completion Date

February 13, 2032

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DIAGNOSTIC_TEST

Tumor Imaging

Participants will undergo tumor imaging using either a magnetic resonance imaging (MRI) scan or a computed tomography (CT) scan.

PROCEDURE

Tumor Tissue Collection

Participants without archival tumor tissue samples will undergo tumor tissue collection for newly obtained tumor tissue.

PROCEDURE

Blood Sample Collection

"Participants will have blood samples drawn for analysis of:~* genetics~* ribonucleic acid (RNA)~* serum biomarker~* plasma biomarker~* circulating tumor DNA (ctDNA)"

Trial Locations (40)

1121

RECRUITING

Orszagos Koranyi Pulmonologiai Intezet ( Site 0060), Budapest

5004

RECRUITING

Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 0061), Szolnok

9024

RECRUITING

Petz Aladar Megyei Oktato Korhaz ( Site 0062), Győr

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0034), New York

13620

RECRUITING

Seoul National University Bundang Hospital ( Site 0081), Seongnam-si

19104

RECRUITING

Abramson Cancer Center of the University of Pennsylvania ( Site 0010), Philadelphia

20007

COMPLETED

Georgetown University ( Site 0036), Washington D.C.

20132

RECRUITING

IRCCS Ospedale San Raffaele ( Site 0171), Milan

21237

ACTIVE_NOT_RECRUITING

MedStar Franklin Square Medical Center ( Site 0033), Baltimore

28223

RECRUITING

Hospital Universitario Quiron Madrid ( Site 0091), Madrid

43210

RECRUITING

Ohio State University Comprehensive Cancer Center ( Site 0015), Columbus

44195

RECRUITING

Cleveland Clinic Main ( Site 0006), Cleveland

50134

RECRUITING

Azienda Ospedaliera Universitaria Careggi ( Site 0173), Florence

57104

RECRUITING

Sanford Cancer Center ( Site 0038), Sioux Falls

58102

RECRUITING

Sanford Fargo Medical Center ( Site 0039), Fargo

68130

RECRUITING

Oncology Hematology West, PC DBA Nebraska Cancer Specialists ( Site 0031), Omaha

77030

RECRUITING

The University of Texas MD Anderson Cancer Center ( Site 0009), Houston

85234

RECRUITING

Banner MD Anderson Cancer Center ( Site 0001), Gilbert

91010

COMPLETED

City of Hope ( Site 0014), Duarte

94158

COMPLETED

UCSF Medical Center at Mission Bay ( Site 0007), San Francisco

3109601

RECRUITING

Rambam Health Care Campus-Oncology ( Site 0076), Haifa

4428132

RECRUITING

Meir Medical Center ( Site 0071), Kfar Saba

4941492

RECRUITING

Rabin Medical Center ( Site 0074), Petah Tikva

5262000

RECRUITING

Chaim Sheba Medical Center ( Site 0070), Ramat Gan

6423906

RECRUITING

Sourasky Medical Center ( Site 0077), Tel Aviv

8457108

COMPLETED

Soroka Medical Center ( Site 0072), Beersheba

9103102

RECRUITING

Shaare Zedek Medical Center ( Site 0075), Jerusalem

40536-0293

RECRUITING

University of Kentucky Markey Cancer Center ( Site 0019), Lexington

02114

RECRUITING

Massachusetts General Hospital ( Site 0003), Boston

02215

RECRUITING

Dana Farber Cancer Institute ( Site 0002), Boston

03766

RECRUITING

Dartmouth Hitchcock Medical Center ( Site 0016), Lebanon

07601

COMPLETED

John Theurer Cancer Center at Hackensack University Medical Center ( Site 0037), Hackensack

00168

RECRUITING

Policlinico Gemelli di Roma ( Site 0174), Roma

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 0151), Warsaw

80-952

RECRUITING

Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit ( Site 0150), Gdansk

75-581

ACTIVE_NOT_RECRUITING

Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 0152), Koszalin

03722

RECRUITING

Severance Hospital ( Site 0080), Seoul

06351

RECRUITING

Samsung Medical Center ( Site 0082), Seoul

08907

RECRUITING

ICO L Hospitalet ( Site 0090), L'Hospitalet de Llobregat

08008

RECRUITING

Hospital Clínic de Barcelona ( Site 0092), Barcelona

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY