Study to Evaluate Safety and Daytime Sedation in Subjects With Parkinson's Disease With Neuropsychiatric Symptoms Treated With Pimavanserin or Low-Dose Quetiapine

PHASE2TerminatedINTERVENTIONAL
Enrollment

11

Participants

Timeline

Start Date

October 23, 2019

Primary Completion Date

September 25, 2020

Study Completion Date

September 25, 2020

Conditions
Parkinson's Disease
Interventions
DRUG

Pimavanserin

Pimavanserin 34 mg (provided as 2×17 mg encapsulated tablets) administered orally as a single dose once daily

OTHER

Placebo

Placebo (provided as 2 × placebo encapsulated tablets) administered orally as a single dose once daily

DRUG

Quetiapine

Quetiapine 25 mg (provided as 1×25 mg quetiapine encapsulated tablet and 1 × placebo encapsulated tablet), OR 50 mg (provided as 2×25 mg quetiapine encapsulated tablets), OR 100 mg (provided as 2×50 mg quetiapine encapsulated tablets) administered orally as a single dose once daily

Trial Locations (16)

27612

M3 Wake Research, Inc., Raleigh

29615

Prisma Health-Upstate, Greenville

30016

Galiz Research, Hialeah

31406

Meridian Clinical Research, Savannah

32159

Charter Research, LLC, Lady Lake

32792

Charter Research, LLC, Winter Park

33122

Premier Clinical Research Institute, Inc., Miami

33351

Infinity Clinical Research, LLC, Sunrise

45459

Dayton Center for Neurological Disorders, Centerville

48170

SRI International, Plymouth

52242

University of lowa Hospital and Clinics, Iowa City

85258

Movement Disorders Center of Arizona, Scottsdale

85710

Tucson Neuroscience Research, Tucson

95816

Sutter Institute for Medical Research, Sacramento

96817

Hawaii Pacific Neuroscience, LLC., Honolulu

08755

Bio Behavioral Health, Toms River

Sponsors
All Listed Sponsors
lead

ACADIA Pharmaceuticals Inc.

INDUSTRY