A Study Evaluating Safety and Efficacy of Venetoclax in Combination With Azacitidine Versus Standard of Care After Allogeneic Stem Cell Transplantation (SCT) in Participants With Acute Myeloid Leukemia (AML)

PHASE3TerminatedINTERVENTIONAL
Enrollment

465

Participants

Timeline

Start Date

February 26, 2020

Primary Completion Date

September 23, 2025

Study Completion Date

September 23, 2025

Conditions
Acute Myeloid Leukemia (AML)Cancer
Interventions
DRUG

Venetoclax

Tablet; Oral

DRUG

Azacitidine

Subcutaneous (SC) or intravenous (IV) injection

OTHER

Best Supportive Care (BSC)

BSC is the best supportive care, without AML directed therapy, determined per the investigator and institutional guidelines.

Trial Locations (165)

100

National Taiwan University Hospital /ID# 215245, Taipei City

333

Linkou Chang Gung Memorial Hospital /ID# 215319, Taoyuan

807

Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 215197, Kaohsiung City

2010

The Kinghorn Cancer Centre /ID# 214660, Darlinghurst

3000

Peter MacCallum Cancer Ctr /ID# 214653, Melbourne

3004

The Alfred Hospital /ID# 240931, Melbourne

4031

Duplicate_Universitätsspital Basel /ID# 215892, Basel

4032

Debreceni Egyetem-Klinikai Kozpont /ID# 241123, Debrecen

5000

Royal Adelaide Hospital /ID# 215678, Adelaide

8006

University Hospital Zurich /ID# 215891, Zurich

10065

Weill Cornell Medical College /ID# 214887, New York

10126

A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 216148, Turin

10467

Montefiore Medical Center - Moses Campus /ID# 241669, The Bronx

10676

General Hospital of Athens Evangelismos /ID# 238810, Athens

11217

Taipei Veterans General Hosp /ID# 239289, Taipei

12462

University General Hospital Attikon /ID# 238812, Athens

14263

Roswell Park Cancer Institute /ID# 217857, Buffalo

15212

Duplicate_Allegheny General Hospital /ID# 216756, Pittsburgh

15232

UPMC Hillman Cancer Ctr /ID# 213715, Pittsburgh

19104

Perelman Center for Advanced Medicine /ID# 214518, Philadelphia

20132

IRCCS Ospedale San Raffaele /ID# 214311, Milan

20141

Istituto Europeo Di Oncologia /ID# 242579, Milan

21201

University of Maryland, Baltimore /ID# 213855, Baltimore

23219

Virginia Commonwealth University Medical Center Main Hospital /ID# 239203, Richmond

25030

CHU de Besancon - Jean Minjoz /ID# 241171, Besançon

25123

ASST degli Spedali Civili di Brescia /ID# 215997, Brescia

26504

University General Hospital of Patras /ID# 238811, RION Patras Achaia

27157

Wake Forest Univ HS /ID# 239210, Winston-Salem

27514

University of North Carolina /ID# 215814, Chapel Hill

28007

Hospital General Universitario Gregorio Maranon /ID# 215107, Madrid

28034

Hospital Universitario Ramon y Cajal /ID# 218102, Madrid

28046

Hospital Universitario La Paz /ID# 218103, Madrid

30625

Medizinische Hochschule Hannover /ID# 214243, Hanover

32224

Mayo Clinic /ID# 239710, Jacksonville

33604

Duplicate_CHU Bordeaux - Hopital Haut Leveque /ID# 214055, Pessac

40447

China Medical University Hospital /ID# 215198, Taichung

40705

Taichung Veterans General Hospital /ID# 239288, Taichung

41013

Hospital Universitario Virgen del Rocio /ID# 215463, Seville

44000

CHU de Nantes, Hotel Dieu -HME /ID# 214060, Nantes

46010

Hospital Clinico Universitario de Valencia /ID# 215106, Valencia

46237

Indiana Blood & Marrow Transpl /ID# 215842, Indianapolis

48149

Universitaetsklinikum Muenster /ID# 215213, Münster

52621

Sheba Medical Center /ID# 239571, Ramat Gan

55455

Masonic Cancer Center /ID# 239492, Minneapolis

59037

CHRU Lille - Hopital Claude Huriez /ID# 217916, Lille

60153

Loyola University Medical Ctr /ID# 215617, Maywood

60611

Ann & Robert H Lurie Children's Hospital of Chicago /ID# 215840, Chicago

69120

Universitaetsklinik Heidelberg /ID# 216623, Heidelberg

70121

Duplicate_Ochsner Clinic Foundation-New Orleans /ID# 213834, New Orleans

72205

University of Arkansas for Medical Sciences /ID# 239804, Little Rock

75010

Hôpital Saint-Louis /ID# 214054, Paris

75012

AP-HP - Hopital Saint-Antoine /ID# 216957, Paris

75013

Hopital Pitie Salpetriere /ID# 241072, Paris

75230

Texas Oncology - Medical City Dallas /ID# 216720, Dallas

78229

Texas Transplant Institute /ID# 214691, San Antonio

80218

Colorado Blood Cancer Institute /ID# 215980, Denver

85724

University of Arizona Cancer Center - Tucson /ID# 242507, Tucson

86156

Klinikum Augsburg /ID# 239583, Augsburg

91010

City of Hope /ID# 213681, Duarte

91120

Hadassah Medical Center-Hebrew University /ID# 218697, Jerusalem

97080

Universitaetsklinikum Wuerzburg /ID# 215212, Würzburg

97239

Oregon Health and Science University /ID# 215874, Portland

100044

Peking University People's Hospital /ID# 215551, Beijing

100853

Chinese PLA General Hospital /ID# 216287, Beijing

200433

Shanghai Changhai Hospital /ID# 216334, Shanghai

210009

Zhongda Hospital Southeast University /ID# 218926, Nanjing

215006

The First Affiliated Hospital of Soochow University /ID# 216605, Suzhou

221006

The Affiliated Hospital of Xuzhou Medical College /ID# 239098, Xuzhou

300020

Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 215546, Tianjin

310003

The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 215550, Hangzhou

330006

The First Affiliated Hospital of Nanchang University /ID# 239168, Nanchang

350001

Fujian Medical University Union Hospital /ID# 215555, Fuzhou

410008

Xiangya Hospital Central South University /ID# 219025, Changsha

430022

Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 215552, Wuhan

Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 238373, Wuhan

450008

Henan Cancer Hospital /ID# 215554, Zhengzhou

510080

Guangdong Provincial People's Hospital /ID# 218666, Guangzhou

510280

Zhujiang Hospital of Southern Medical University /ID# 216333, Guangzhou

510515

Nanfang Hospital of Southern Medical University /ID# 215553, Guangzhou

518039

Shenzhen Second People's Hospital /ID# 239401, Shenzhen

710038

Tangdu Hospital of The Fourth Military Medical University, PLA /ID# 216282, Xi’an

861059

Aerospace Center Hospital /ID# 217018, Beijing

3109601

Rambam Health Care Campus /ID# 214507, Haifa

4920235

Schneider Children's Medical Center /ID# 224326, Petah Tikva

4941492

Rabin Medical Center /ID# 214509, Petah Tikva

5265601

The Chaim Sheba Medical Center /ID# 214305, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center /ID# 214508, Tel Aviv

9808574

Tohoku University Hospital /ID# 214670, Sendai

85258-4547

Arizona Oncology - Scottsdale - Cancer Transplant Institute /ID# 239711, Scottsdale

80045-2517

UCHSC Anschultz Cancer Pavilion /ID# 215618, Aurora

32804-5505

AdventHealth Medical Group Blood & Marrow Transplant at Orlando /ID# 213985, Orlando

60637-1443

The University of Chicago Medical Center /ID# 215616, Chicago

02114

Massachusetts General Hospital /ID# 215765, Boston

48201-2013

Karmanos Cancer Institute - Dresner Clinic /ID# 214581, Detroit

55905-0001

Mayo Clinic - Rochester /ID# 214685, Rochester

39216-4500

University of Mississippi Medical Center /ID# 239343, Jackson

07601

The John Theurer Cancer /ID# 215251, Hackensack

10032-3729

Columbia University Medical Center /ID# 240875, New York

10065-6007

Memorial Sloan Kettering Cancer Center-Koch Center /ID# 240680, New York

45267-2800

UC Health - Cincinnati /ID# 239263, Cincinnati

44106-1716

University Hospitals - Seidman Cancer Center /ID# 239260, Cleveland

73104-5418

University of Oklahoma, Stephenson Cancer Center /ID# 215611, Oklahoma City

17033-2360

Penn State Hershey Medical Ctr /ID# 217120, Hershey

19104-4319

Children's Hospital of Philadelphia - Main /ID# 215410, Philadelphia

37203-1551

TriStar Centennial Medical Center /ID# 218750, Nashville

75246-2003

Texas Oncology- Baylor Charles A. Sammons Cancer Center /ID# 213735, Dallas

98109-1024

Fred Hutchinson Cancer Research Center /ID# 214436, Seattle

53792-0001

Univ of Wisconsin Hosp/Clinics /ID# 216096, Madison

90035-903

Hospital de Clinicas de Porto Alegre /ID# 215042, Porto Alegre

17210-070

Hospital Amaral Carvalho - Fundacao Doutor Amaral Carvalho /ID# 215145, Jaú

01409-001

Hospital Nove de Julho /ID# 242359, São Paulo

05403-000

Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 239516, São Paulo

V5Z 1M9

Vancouver Coastal Health Research Institute (VCHRI) /ID# 215363, Vancouver

M5G 2M9

University Health Network_Princess Margaret Cancer Centre /ID# 215344, Toronto

H1T 2M4

CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 214591, Montreal

H4A 3J1

Royal Victoria Hospital / McGill University Health Centre /ID# 215253, Montreal

S7N 4H4

Saskatoon Cancer Centre /ID# 238821, Saskatoon

625 00

Fakultní Nemocnice Brno - Jihlavská /ID# 214811, Brno

500 05

Fakultní nemocnice Hradec Králové - Sokolská /ID# 214814, Hradec Králové

708 52

Fakultni Nemocnice Ostrava /ID# 239922, Ostrava

128 00

Ustav hematologie a krevni transfuze /ID# 215133, Prague

06200

Duplicate_CHU de Nice - Hôpital Archet 1 /ID# 214056, Nice

01307

Universitaetsklinikum Carl Gustav Carus Dresden /ID# 214244, Dresden

04103

Universitaetsklinikum Leipzig /ID# 245892, Leipzig

06120

Universitaetsklinikum Halle (Saale) /ID# 239585, Halle

00161

Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 254964, Rome

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 214910, Rome

446-8602

Anjou Kousei Hospital /ID# 215857, Anjo-shi

453-8511

Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital /ID# 215679, Nagoya

910-1104

University of Fukui Hospital /ID# 253383, Yoshida-gun

812-8582

Kyushu University Hospital /ID# 215285, Fukuoka

960-1295

Fukushima Medical University Hospital /ID# 252293, Fukushima

730-8619

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital /ID# 217522, Hiroshima

060-8648

Hokkaido University Hospital /ID# 215937, Sapporo

650-0047

Kobe City Medical Center General Hospital /ID# 215388, Kobe

663-8501

Hyogo Medical University Hospital /ID# 215389, Nishinomiya-shi

920-8641

Kanazawa University Hospital /ID# 242955, Kanazawa

890-0064

Imamura General Hospital /ID# 215688, Kagoshima

259-1193

Tokai University Hospital /ID# 250086, Isehara

241-8515

Kanagawa Cancer Center /ID# 215029, Yokohama

606-8507

Kyoto University Hospital /ID# 243209, Kyoto

700-8558

Okayama University Hospital /ID# 214842, Okayama

545-8586

Osaka Metropolitan University Hospital /ID# 215227, Osaka

589-8511

Kindai University Hospital /ID# 214917, Osakasayama-shi

330-8503

Jichi Medical University Saitama Medical Center /ID# 216092, Saitama-shi

329-0498

Jichi Medical University Hospital /ID# 216091, Shimotsuke-shi

113-8677

Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital /ID# 215939, Bunkyo-ku

104-0045

National Cancer Center Hospital /ID# 242639, Chuo-ku

105-8470

Toranomon Hospital /ID# 215311, Minato-ku

157-8535

National Center for Child Health and Development /ID# 242479, Setagaya-ku

160-8582

Keio University Hospital /ID# 243549, Shinjuku-ku

990-9585

Yamagata University Hospital /ID# 253304, Yamagata

03080

Seoul National University Hospital /ID# 214891, Seoul

05505

Asan Medical Center /ID# 214893, Seoul

06351

Samsung Medical Center /ID# 239087, Seoul

06591

The Catholic University of Korea, Seoul St. Marys Hospital /ID# 214892, Seoul

08036

Hospital Clinic de Barcelona /ID# 215108, Barcelona

08041

Hospital Santa Creu i Sant Pau /ID# 240397, Barcelona

W12 0HS

Hammersmith Hospital /ID# 215665, London

G12 0YN

Gartnavel General Hospital /ID# 215663, Glasgow

NW1 2BU

University College London Hospital /ID# 215662, London

B15 2TH

University Hospitals Birmingham NHS Foundation Trust /ID# 215120, Birmingham

SE5 9RS

King's College Hospital NHS Foundation Trust /ID# 215338, London

SW3 6JJ

The Royal Marsden NHS Foundation Trust /ID# 215124, London

NE3 3HD

The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 248359, Newcastle upon Tyne

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