Study of Autophagy and the Effects of GALIG Gene Products in HIV-1 Infected Patients Who Are Under Antiretroviral Therapy Since Primary-infection, Chronic Phase, or Never Treated.

RecruitingOBSERVATIONAL
Enrollment

180

Participants

Timeline

Start Date

November 7, 2019

Primary Completion Date

November 7, 2029

Study Completion Date

November 7, 2039

Conditions
AutophagyGalectinsHIV InfectionsHighly Active Antiretroviral Therapy
Interventions
BIOLOGICAL

expression of a panel

Quantify, by droplet digital PCR, the expression of a panel of 7 genes (+ GALIG) involved in autophagy2 on sub-populations (CD4+ and CD8+ lymphocytes and monocytes) after their sorting using magnetic bead cell then RNA extraction Evaluate, on a functional test (as previously described1), whether the observed expression dysregulation is associated with a deregulation of the autophagic function, whether constitutive or induced.

Trial Locations (1)

45067

RECRUITING

CHR d'Orleans, Orléans

All Listed Sponsors
lead

Centre Hospitalier Régional d'Orléans

OTHER