Transforming Hypertension Treatment in Nigeria Using a Type II Hybrid, Interrupted Time Series Design

NACompletedINTERVENTIONAL
Enrollment

21,922

Participants

Timeline

Start Date

February 1, 2020

Primary Completion Date

December 31, 2023

Study Completion Date

December 31, 2023

Conditions
Hypertension
Interventions
OTHER

Evidence-based fixed-dose combination protocol based treatment

The intervention has been adapted based on a local needs' assessment including exploration of health care workers and patient's knowledge, attitudes, and behaviors related to HTN, causes, consequences, and treatment. Implementation pathways have been developed with particular attention to overcoming modifiable barriers to HTN treatment and control across capability, intentional, and system domains using CFIR. Sites will randomly be assigned to receive either: Step 1 amlodipine 5mg; Step 2 amlodipine 5 mg + losartan 50 mg (as 2 separate pills); Step 3 amlodipine 10 mg + losartan 100 mg (as 4 separate pills); Step 4 amlodipine 10/losartan 100/HCTZ 25 (as 2 single pill combo) or Step 1 amlodipine 5mg; Step 2 amlodipine 5 mg + losartan 50 mg (as 1 single pill combo); Step 3 amlodipine 10 mg + losartan 100 mg (as 2 single pill combo); Step 4 amlodipine 10/losartan 100/HCTZ 25 (as 2 single pill combo).

Trial Locations (60)

Unknown

Agyana PHC, Abaji

Central PHC, Abaji

Gawu PHC, Abaji

Low Cost PHC, Abaji

Naharati PHC, Abaji

New Township Clinic, Abaji

Rimba PHC, Abaji

Yaba PHC, Abaji

Dakwa PHC, Abuja

Gbagarape PHC, Abuja

Gidan Mangoro PHC, Abuja

Gosa PHC, Abuja

Gwagwa PHC, Abuja

Jikwoyi PHC, Abuja

Kagini PHC, Abuja

Karon Majigi PHC, Abuja

Karshi PHC, Abuja

Karu PHC, Abuja

Kuchingoro PHC, Abuja

Lugbe PHC, Abuja

New Garki Apo PHC, Abuja

Orozo PHC, Abuja

Pykassa PHC, Abuja

Byazhin PHC, Bwari

Dei-Dei PHC, Bwari

Kawu PHC, Bwari

Kogo PHC, Bwari

Mpape PHC, Bwari

Sabon Gari PHC, Bwari

Shere PHC, Bwari

Ushafa PHC, Bwari

Anagada PHC, Gwagwalada

Dagiri CPHC, Gwagwalada

Dobi PHC, Gwagwalada

Dukpa PHC, Gwagwalada

Gwagwalada Township Clinic, Gwagwalada

Gwako PHC, Gwagwalada

Old-Kutunku PHC, Gwagwalada

Paikon PHC, Gwagwalada

Rafin Zurfi PHC, Gwagwalada

Yimi PHC, Gwagwalada

Zuba PHC, Gwagwalada

Chukuku PHC, Kuje

Gaube CPHC, Kuje

Gudunkarya PHC, Kuje

Gwargada PHC, Kuje

Kiyi PHC, Kuje

Kuje PHC, Kuje

Kujekwa PHC, Kuje

Pegi PHC, Kuje

Ashara PHC, Kwali

Dabi Bako CPHC, Kwali

Dafa PHC, Kwali

Gomani PHC, Kwali

Kwaita Hausa PHC, Kwali

Kwaita Model PHC, Kwali

Kwali PHC, Kwali

Petti PHC, Kwali

Wako PHC, Kwali

Yangoji PHC, Kwali

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

University of Abuja Teaching Hospital

OTHER

collaborator

Resolve to Save Lives

OTHER

lead

Washington University School of Medicine

OTHER

NCT04158154 - Transforming Hypertension Treatment in Nigeria Using a Type II Hybrid, Interrupted Time Series Design | Biotech Hunter | Biotech Hunter