EBV-TCR-T Cells for EB Virus Infection After HSCT

PHASE1CompletedINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

February 10, 2020

Primary Completion Date

July 30, 2021

Study Completion Date

October 31, 2021

Conditions
EBV Emia and EBV Positive PTLD After Allogenic HSCT
Interventions
BIOLOGICAL

EBV-TCR-T cells

EBV-TCR-T cells are prepared via lentiviral infection. patients with EBV emias or EBV positive PTLD will be enrolled, and donor derived EBV-TCR-T(HLA-A\*1101\\0201\\2402) cells will be intravenously infused with a escalated dose of 0.1-1×106 EBV-TCR-T cells. The EBV DNA copies and EBV-TCR-T cell proliferation will be monitored in the scheduled time (day 0, day 4, day 7, day 10, day 14, day 28).

Trial Locations (1)

065200

Hebei Yanda Ludaopei Hospital, Sanhe

All Listed Sponsors
collaborator

China Immunotech (Beijing) Biotechnology Co., Ltd.

INDUSTRY

lead

Hebei Yanda Ludaopei Hospital

OTHER

NCT04156217 - EBV-TCR-T Cells for EB Virus Infection After HSCT | Biotech Hunter | Biotech Hunter