81
Participants
Start Date
March 23, 2020
Primary Completion Date
June 22, 2022
Study Completion Date
August 17, 2023
Lenvatinib
"Lenvatinib 14 milligrams per square meter (mg/m\^2) capsules will be administered once daily on Days 1 to 21 of each 21-day cycle until disease progression (PD), development of unacceptable toxicity, participant request, withdrawal of consent, or discontinuation of study by the sponsor.~An extemporaneous suspension of lenvatinib capsules may be used for participants unable to swallow capsules."
Ifosfamide
Ifosfamide 3000 milligrams per square meter per day (mg/m\^2/day) intravenous infusion will be administered on Days 1 to 3 of each 21-day cycle for a total of 5 cycles.
Etoposide
Etoposide 100 mg/m\^2/day intravenous infusion will be administered on Days 1 to 3 of each 21-day cycle for a total of 5 cycles.
Lenvatinib
Lenvatinib 14 mg/m\^2 capsules will be administered once daily on Days 1 to 21 of each 21-day cycle until the next PD (per response evaluation criteria in solid tumors \[RECIST\] 1.1 as assessed by investigator), development of unacceptable toxicity, participant request, or withdrawal of consent, whichever occurs first.
Memorial Sloan Kettering Cancer Center, New York
Children's National Medical Center, Washington D.C.
Children's of Alabama, Birmingham
Vanderbilt University Medical Center, Nashville
University of Mississippi Medical Center, Jackson
Cincinnati Children's Hospital Medical Center, Cincinnati
Riley Hospital For Children, Indianapolis
Children's Medical Center Dallas, Dallas
Cook Children's Health Care System, Fort Worth
Texas Children's Hospital, Houston
Childrens Hospital Colorado, Aurora
Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
UCSF Benioff Children's Hospitals, San Francisco
Dana Farber Cancer Institute, Boston
Hackensack University Medical Center, Hackensack
Chris O'Brien Lifehouse Hospital, Camperdown
Perth Childrens Hospital, Nedlands
Royal Children's Hospital Melbourne, Parkville
Queensland Children's Hospital, South Brisbane
Children's Hospital at Westmead, Westmead
St. Anna Kinderspital, Vienna
UZ Gent, Ghent
Hospital For Sick Children, Toronto
FN Brno 2 Detska Klinika, Brno
Fakultní nemocnice v Motole, Prague
Centre Hospitalier Universitaire de Bordeaux, Hopital Pellegrin, Bordeaux
Centre Oscar Lambret, Lille
Centre Léon Berard, Lyon
Hopitaux de La Timone, Marseille
Hôpital de La Mère Et de L'enfant, Nantes
CHU de Nice, Nice
Hôpital Armand Trousseau, Paris
Institut Curie, Paris
Hopital de Hautepierre, Strasbourg
Hôpital Des Enfants, Toulouse
CHRU Nancy, Vandœuvre-lès-Nancy
Institut Gustave Roussy, Villejuif
Hong Kong Children's Hospital, Hong Kong
Prince of Wales Hospital, Hong Kong
Children's Health Ireland at Crumlin, Dublin
Schneider Children's Medical Center of Israel, Petah Tikva
Istituti Ortopedici Rizzoli, Bologna
Azienda Ospedaliera A Meyer, Florence
Istituto Giannina Gaslini, Genova
Istituto Nazionale Dei Tumori, Milan
IRCCS Ospedale Pediatrico Bambino Gesù, Roma
Princess Maxima Center for Pediatric Oncology, Utrecht
Auckland City Hospital, Auckland
Starship Children's Hospital, Auckland
KK Women's and Children's Hospital, Singapore
National Cancer Centre, Singapore
National University Hospital, Singapore
National Cancer Center, Goyang-si
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Seoul National University Hospital, Seoul
Severance Hospital Yonsei University Health System, Seoul
Hospital Universitario de Cruces, Barakaldo
Hospital Sant Joan de Deu, Barcelona
Hospital Universitario Vall d'Hebrón, Barcelona
Hospital Infantil Universitario Niño Jesus, Madrid
Hospital Universitario Fundacion Jimenez Diaz, Madrid
Hospital Universitario La Paz, Madrid
Hospital Universitario Virgen del Rocio, Seville
Hospital Universitari i Politecnic La Fe de Valencia, Valencia
Drottning Silvias Barn Och Ungdomssjukhus, Gothenburg
Skanes Universitetssjukhus Lund, Lund
Karolinska Universitetssjukhuset Solna, Stockholm
Centre Hospitalier Universitaire Vaudois, Lausanne
Kinderspital Zürich - Eleonorenstiftung, Zurich
National Taiwan University Hospital, Taipei
Taipei Veterans General Hospital, Taipei
Birmingham Children's Hospital, Birmingham
The Royal Hospital for Children, Bristol
Royal Hospital for Children, Glasgow
Leeds Children Hospital, Leeds
Alder Hey Children's Hospital, Liverpool
UCL Cancer Institute, London
Royal Manchester Childrens Hospital, Manchester
The Christie NHS Foundation Trust, Manchester
Royal Victoria Infirmary, Newcastle
John Radcliffe Hospital, Oxford
Tampereen yliopistollinen sairaala, Tampere
Merck Sharp & Dohme LLC
INDUSTRY
Eisai Inc.
INDUSTRY