200
Participants
Start Date
October 30, 2019
Primary Completion Date
May 30, 2020
Study Completion Date
June 30, 2020
pulse photoplethysmography (PPG)
PPG and systolic blood pressure recording will be performed every two hours for three consecutive days. PPG reading will last two minutes and peaks of NO productions will be captured. Day 1 is considered the day of signing the informed consent followed by the first recording. On the first PPG recording of the same days i.e. on days 1, 2 and 3 the investigators will collect blood from the patients
Measurements of nitric oxide (NO) and malondialdehyde (MDA)
On the first PPG recording of the same days i.e. on days 1, 2 and 3 the investigators will collect blood from the patients. NO will be measured in serum samples by the Griess reaction. MDA that is considered an index of oxidant status will be measured in serum samples by the thiobarbiturate assay and analysis by high-performance liquid chromatography (HPLC)
"Intensive Care Unit, Korgialenio - Benakio General Hospital of Athens", Athens
"Department of Clinical Therapeutics, Alexandra General Hospital of Athens, National and Kapodistrian University of Athens, Medical School", Athens
"2nd Department of Critical Care, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School", Athens
"4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School", Athens
Hellenic Institute for the Study of Sepsis
OTHER