Effect of IV Infusion of Lidocaine Compared to IV Infusion of Dexmedetomidine on Proinflammatory Cytokines

PHASE3CompletedINTERVENTIONAL
Enrollment

54

Participants

Timeline

Start Date

January 2, 2018

Primary Completion Date

June 10, 2020

Study Completion Date

June 13, 2020

Conditions
Inflammatory Response
Interventions
DRUG

dexmedetomidine infusion

a loading dose of 1µg/kg of dexmedetomidine (precedex) made to 50 ml using normal saline will be given over 10 minutes followed by infusion of dexmedetomidine with a dose of 0.5µg/kg/hour till the end of surgery.

DRUG

lidocaine infusion

a loading dose of 1.5 mg/kg of lidocaine made to 50 ml using normal saline and given over 10 minutes followed by infusion of lidocaine with a dose of 1.5 mg/kg/hour till the end of surgery.

DRUG

Placebos

50 ml of normal saline given over 10 minutes followed by saline infusion intraoperatively at a rate of 10 ml/hour till the end of surgery.

Trial Locations (1)

11769

National cancer institute, Cairo

All Listed Sponsors
collaborator

Abdelhamid, Bassant Mohamed, M.D.

INDIV

lead

Norma Osama Abdalla Zayed

OTHER

NCT04148599 - Effect of IV Infusion of Lidocaine Compared to IV Infusion of Dexmedetomidine on Proinflammatory Cytokines | Biotech Hunter | Biotech Hunter