An Open-Label Study of JZP-458 (RC-P) in Patients With Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL)

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

229

Participants

Timeline

Start Date

December 27, 2019

Primary Completion Date

July 13, 2022

Study Completion Date

July 13, 2022

Conditions
Acute Lymphoblastic LeukemiaLymphoblastic Leukemia
Interventions
DRUG

IM JZP-458

IM JZP-458 will be administered in Part A, Cohorts 1 \& 2

DRUG

IV JZP-458

IV JZP-458 will be administered in Part B

Trial Locations (74)

10016

NYU - Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, New York

10032

Herbert Irving Comprehensive Cancer Center, New York

10065

Memorial Sloan-Kettering Cancer Center - New York, New York

11040

Cohen Children's Medical Center, New Hyde Park

15224

University of Pittsburgh Medical Center - Children's Hospital of Pittsburgh, Pittsburgh

19104

Children's Hospital of Philadelphia, Philadelphia

19803

Nemours Alfred I. Dupont Hospital for Children, Wilmington

20010

Children's National Health System, Washington D.C.

22042

Inova Medical Group - Fairfax Hospital, Falls Church

23220

Massey Cancer Center, Richmond

23507

Children's Hospital of The King's Daughters, Norfolk

27157

Wake Forest Baptist Health, Winston-Salem

30342

Scottish Rite Hospital, Atlanta

32207

Nemours Children's Specialty Care Jacksonville, Jacksonville

32803

AdventHealth Orlando, Orlando

33021

Memorial Medical Office Centre, Hollywood

33701

Johns Hopkins All Children's Hospital, St. Petersburg

33908

Golisano Children's Hospital of Southwest Florida, Fort Myers

35233

Children's of Alabama, Birmingham

37232

Vanderbilt University Medical Center, Nashville

37913

East Tennessee Children's Hospital, Knoxville

38018

Neurology Clinic, P.C, Cordova

38105

St. Jude Children's Research Hospital, Memphis

39216

University of Mississippi Medical Center, Jackson

40202

Norton Children's Hospital, Louisville

43205

Nationwide Children's Hospital, Columbus

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

48109

C.S. Mott Children's Hospital, Ann Arbor

55404

Children's Minnesota, Minneapolis

55455

Masonic Cancer Center, Minneapolis

60611

Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago

63110

Washington University School of Medicine in Saint Louis, St Louis

72202

Arkansas Children's Hospital, Little Rock

73104

The Children's Hospital at Oklahoma University Medical Center, Oklahoma City

75230

Medical City Dallas Hospital, Dallas

75390

University of Texas Southwestern Medical Center, Dallas

77030

Texas Children's Hospital, Houston

78229

Methodist Hospital - San Antonio, San Antonio

78723

Children's Blood and Cancer Center, Austin

84113

Primary Children's Hospital, Salt Lake City

85016

Phoenix Children's Hospital, Phoenix

89135

Alliance for Childhood Diseases, Las Vegas

90027

Children's Hospital Los Angeles, Los Angeles

Kaiser Permanente- Los Angeles Medical Center, Los Angeles

90242

Kaiser Permanente - Downey Medical Center, Downey

90806

MemorialCare Miller Children's and Women's Hospital Long Beach, Long Beach

92120

Kaiser Permanente - San Diego Medical Center, San Diego

92335

Kaiser Permanente - Fontana Medical Center, Fontana

92350

Loma Linda University Medical Center, Loma Linda

92806

Kaiser Permanente - Orange County - Anaheim Medical Center, Anaheim

92868

Children's Hospital of Orange County Main Campus - Orange, Orange

94158

University of California San Francisco Benioff Children's Hospital - Mission Bay, San Francisco

94609

Benioff Children's Hospital Oakland, Oakland

94611

Kaiser Permanente - Oakland Medical Center, Oakland

95051

Kaiser Permanente - Santa Clara Medical Center, Santa Clara

95661

Kaiser Permanente - Roseville Medical Center, Roseville

95817

University of California Davis Comprehensive Cancer Center, Sacramento

96826

Kapi'olani Medical Center for Women and Children, Honolulu

97201

Oregon Health and Science University, Portland

98105

Seattle Children's Hospital, Seattle

99204

Providence Sacred Heart Medical Center, Spokane

06106

Connecticut Children's Medical Center, Hartford

06511

Smilow Cancer Hospital - New Haven, New Haven

02215

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston

07601

Hackensack University Medical Center, Hackensack

07960

Morristown Medical Center, Morristown

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

R3E 0V9

CancerCare Manitoba - McDermot and Urgent Care Site, Winnipeg

L8N 3Z5

McMaster Children's Hospital, Hamilton

N6C 2V5

Victoria Hospital & Children's Hospital, London

K1H 8L1

Children's Hospital of Eastern Ontario, Ottawa

M5G 1X8

SickKids - The Hospital for Sick Children, Toronto

H3T 1C5

Centre Hospitalier Universitaire Sainte-Justine, Montreal

H4A 3J1

The Montreal Children's Hospital, Montreal

Sponsors
All Listed Sponsors
collaborator

Children's Oncology Group

NETWORK

lead

Jazz Pharmaceuticals

INDUSTRY