Randomised Open Label Trial of Hypertonic Saline and Carbocisteine in Bronchiectasis (CLEAR)

PHASE3CompletedINTERVENTIONAL
Enrollment

288

Participants

Timeline

Start Date

June 27, 2018

Primary Completion Date

September 30, 2024

Study Completion Date

December 18, 2024

Conditions
Bronchiectasis
Interventions
DRUG

Hypertonic saline

Nebulized hypertonic saline solution (6%)

DRUG

Carbocysteine 750 MG

Carbocisteine tablet

Trial Locations (20)

HP21 8AL

Stoke Mandeville Hospital, Aylesbury

Unknown

Belfast City Hospital, Belfast Health and Social Care Trust, Belfast

Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham

Royal Brompton Hospital, Royal Brompton and Harefield NHS Foundation Trust, Brompton

Ninewells Hospital and Medical School, NHS Tayside, Dundee

Royal Infirmary Edinburgh, NHS Lothian, Edinburgh

Royal Free Hospital, Royal Free London NHS Foundation Trust, Hamstead

Princess Alexandra Hospital, The Princess Alexandra Hospital NHS Trust, Harlow

Royal Lancaster Infirmary, University Hospitals of Morecambe Bay NHS Foundation Trust, Lancaster

Altnagelvin Area Hospital, Western Health and Social Care Trust, Londonderry

Freeman Hospital, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle

Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford

Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, Southampton

Royal Gwent Hospital, Aneurin Bevan University Health Board, Wales

FY3 8NR

Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool

BD9 6RJ

Bradford Teaching Hospitals, Bradford

CF64 2XX

Cardiff & Vale University Heath Board, Llandough

MK6 5LD

Milton Keynes University Hospital, Milton Keynes

NE29 8NH

Northumbria NHS Foundation Trust, North Shields

B71 4HJ

Sandwell & West Birmingham, West Bromwich

All Listed Sponsors
collaborator

Queen's University, Belfast

OTHER

lead

Belfast Health and Social Care Trust

OTHER

NCT04140214 - Randomised Open Label Trial of Hypertonic Saline and Carbocisteine in Bronchiectasis (CLEAR) | Biotech Hunter | Biotech Hunter