1,438
Participants
Start Date
March 13, 2020
Primary Completion Date
April 30, 2026
Study Completion Date
August 31, 2026
Eplontersen
Eplontersen by subcutaneous injection
Placebo
Eplontersen-matching placebo by subcutaneous injection
Medizinische Universität Wien, Vienna
Rigshospitalet, Copenhagen
Liverpool Hospital, Liverpool
Box Hill Hospital, Box Hill
Ziekenhuis Oost-Limburg - Campus Sint-Jan, Genk
Princess Alexandra Hospital, Woolloongabba
Odense Universitetshospital, Odense
Advara Heartcare, Leabrook
Medizinische Universität Innsbruck, Innsbruck
Advara HeartCare, Joondalup
Advara HeartCare Murdoch, Murdoch
Royal Hobart Hospital, Hobart
Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan, Bruges
Medizinische Universität Graz, Graz
New York University Langone Cardiology Associates, New York
Columbia University Irving Medical Center, New York
Weill Cornell Medicine Cardiology, New York
Charité Campus Mitte, Berlin
Laurelton Heart Specialists, Rosedale
Alexandra General Hospital, Athens
Hôpital de la Timone, Marseille
Charité Universitätsmedizin Berlin, Berlin
University of Pittsburgh Medical School, Pittsburgh
Complejo Hospitalario Universitario de Santiago, Santiago de Compostela
Lancaster General Hospital, Lancaster
Penn Presbyterian Medical Center, Philadelphia
MedStar Washington Hospital Center, Washington D.C.
The George Washington Medical Faculty Associates - Foggy Bottom North Pavilion, Washington D.C.
University of Maryland Medical Center, Baltimore
Virginia Commonwealth University (VCU), Richmond
Fondazione IRCCS Policlinico San Matteo, Pavia
The University of North Carolina at Chapel Hill, Chapel Hill
Duke University Medical Center, Durham
Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda
Medical University of South Carolina, Charleston
Hospital Clínico Universitario Virgen de la Arrixaca, Murcia
Piedmont Heart of Fayetteville, Fayetteville
Emory Heart and Vascular Center - Emory Clifton Campus, Atlanta
Hôpital Rangueil, Toulouse
Cleveland Clinic Florida, Weston
Hôpital Haut-Lévêque, Pessac
Azienda Ospedale - Università di Padova, Padua
Vanderbilt University Medical Center, Nashville
Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant Orsola-Malpighi, Bologna
The Ohio State University College of Medicine, Columbus
University Hospitals Cleveland Medical Center, Cleveland
Cleveland Clinic Main Campus, Cleveland
Centre Hospitalier Universitaire De Nantes - Hôpital Nord Laennec, Saint-Herblain
Carl and Edyth Lindner Research Center at The Christ Hospital, Cincinnati
Indiana University Health, Indianapolis
Universitätsklinikum Münster, Münster
Henry Ford Health System, Detroit
Azienda Ospedaliero - Universitaria Careggi, Florence
Uniklinik Koln, Cologne
Froedtert & Medical College of Wisconsin, Milwaukee
University of Wisconsin - Madison, Madison
Minneapolis Heart Institute, Minneapolis
Mayo Clinic - Rochester, Rochester
Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanita Pubblica, Pisa
Azienda Ospedaliero Universitaria Delle Marche, Ancona
Loyola University Medical Center, Maywood
Northwestern University, Chicago
The University of Chicago Medical Center, Chicago
Barnes-Jewish Hospital, St Louis
Saint Luke's Hospital of Kansas City, Kansas City
University of Kansas Medical Center, Kansas City
Universitätsklinikum des Saarlandes, Homburg
Universitaetsklinikum Heidelberg - Zentrum fur Innere Medizin, Heidelberg
Louisiana State University Health Sciences Center, New Orleans
Tulane University Heart and Vascular Institute, New Orleans
Ochsner Health System, New Orleans
University of Texas Southwestern Medical Center, Dallas
Houston Methodist Hospital, Houston
University of Colorado Hospital - Anschutz Medical Campus, Aurora
University of Utah, Salt Lake City
Mayo Clinic - Arizona, Phoenix
Centre Hospitalier Départemental Vendée, La Roche-sur-Yon
Cedars-Sinai Medical Center, Los Angeles
Altman Clinical and Translational Research Institute Center for Clinical Research, La Jolla
Hôpitaux Universitaires Henri Mondor, Créteil
University of California, San Francisco (UCSF) - Medical Center, San Francisco
Stanford Hospital, Stanford
Universitätsklinikum Würzburg, Würzburg
Oregon Health and Science University, Portland
University of Washington, Seattle
Rambam Health Care Campus, Haifa
Hadassah University Hospital Ein Kerem, Jerusalem
Universidade Estadual de Campinas, Campinas
Massachusetts General Hospital, Boston
Brigham and Women's Hospital, Boston
Boston University School of Medicine, Boston
Instituto Cardiovascular de Buenos Aires, Ciudad Autonoma de Buenos Aires
Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires
The Westmead Institute for Medical Research, Westmead
Hospital Moinhos de Vento, Porto Alegre
Centro Avançado de Pesquisa e Estudos para o Diagnóstico CAPED, Ribeirão Preto
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto
A Beneficência Portuguesa de São Paulo - Unidade Mirante, São Paulo
Instituto Dante Pazzanese de Cardiologia, São Paulo
Instituto do Coração de São Paulo, São Paulo
University of Calgary, Calgary
Gordon and Leslie Diamond Health Care Centre, Vancouver
University Hospital - London Health Sciences Centre, London
Toronto General Hospital, Toronto
Centre Hospitalier de l'Université de Montréal (CHUM), Montreal
Hôpital Regional de Rimouski, Rimouski
Fakultní Nemocnice u sv. Anny v Brn, Brno
Vseobecna Fakultni Nemocnice v Praze, Prague
Institut Klinické a Experimentální Medicíny, Prague
Kaplan Medical Center, Rehovot
Azienda Ospedaliera - Universitaria Sant' Andrea, Roma
Uwajima City Hospital, Uwajima-shi
Hospital of the University of Occupational and Environmental Health, Kitakyushu-shi
Kurume University Hospital, Kurume-shi
Sapporo Medical University Hospital, Sapporo
Saiseikai Fukuoka General Hospital, Fukuoka
Kokura Memorial Hospital, Kitakyushu
University Hospital Kyoto Prefectural University of Medicine, Kyoto
Shinshu University Hospital, Matsumoto
Okayama University Hospital, Okayama
Osaka Metropolitan University Hospital, Osaka
Hamamatsu University Hospital, Hamamatsu
Keio University Hospital, Shinjuku-Ku
Kumamoto University Hospital, Kumamoto
Krakowski Szpital Specjalistyczny im. Jana Pawa II, Krakow
Narodowy Instytut Kardiologii Stefana kardyna Wyszyskiego - Pastwowy Instytut Badawczy, Warsaw
Hospital da Senhora da Oliveira - Guimarães, Guimarães
Centro Hospitalar Universitário de Lisboa Central - Hospital de Santa Marta, Lisbon
Centro Hospitalar Universitário do Porto - Hospital Geral de Santo Antonio, Porto
Centro Hospitalar Universitário de São João, Porto
Veterans Affairs Caribbean Healthcare System, San Juan
Hospital Universitari Vall d'Hebrón, Barcelona
Sahlgrenska Universitetssjukhuset, Gothenburg
Skellefteå lasarett, Skellefteå
Synexus - Scotland Clinical Research Centre, Glasgow
Synexus - Wales, Cardiff
Synexus Midlands Clinical Research Centre, Edgbaston
Synexus - North Tees Clinical Research Centre, Hexham
Synexus - Manchester Clinical Research Centre, Liverpool
Synexus - Merseyside Clinical Research Centre, Liverpool
Royal Free London NHS Foundation Trust, London
Richmond Pharmacology, London
Lead Sponsor
Collaborators (1)
AstraZeneca
INDUSTRY
Ionis Pharmaceuticals, Inc.
INDUSTRY