CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,438

Participants

Timeline

Start Date

March 13, 2020

Primary Completion Date

April 30, 2026

Study Completion Date

August 31, 2026

Conditions
Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)
Interventions
DRUG

Eplontersen

Eplontersen by subcutaneous injection

DRUG

Placebo

Eplontersen-matching placebo by subcutaneous injection

Trial Locations (142)

1090

Medizinische Universität Wien, Vienna

2100

Rigshospitalet, Copenhagen

2170

Liverpool Hospital, Liverpool

3128

Box Hill Hospital, Box Hill

3600

Ziekenhuis Oost-Limburg - Campus Sint-Jan, Genk

4102

Princess Alexandra Hospital, Woolloongabba

5000

Odense Universitetshospital, Odense

5068

Advara Heartcare, Leabrook

6020

Medizinische Universität Innsbruck, Innsbruck

6027

Advara HeartCare, Joondalup

6150

Advara HeartCare Murdoch, Murdoch

7000

Royal Hobart Hospital, Hobart

8000

Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan, Bruges

8036

Medizinische Universität Graz, Graz

10016

New York University Langone Cardiology Associates, New York

10034

Columbia University Irving Medical Center, New York

10065

Weill Cornell Medicine Cardiology, New York

10117

Charité Campus Mitte, Berlin

11422

Laurelton Heart Specialists, Rosedale

11528

Alexandra General Hospital, Athens

13005

Hôpital de la Timone, Marseille

13353

Charité Universitätsmedizin Berlin, Berlin

15261

University of Pittsburgh Medical School, Pittsburgh

15706

Complejo Hospitalario Universitario de Santiago, Santiago de Compostela

17602

Lancaster General Hospital, Lancaster

19104

Penn Presbyterian Medical Center, Philadelphia

20010

MedStar Washington Hospital Center, Washington D.C.

20037

The George Washington Medical Faculty Associates - Foggy Bottom North Pavilion, Washington D.C.

21201

University of Maryland Medical Center, Baltimore

23298

Virginia Commonwealth University (VCU), Richmond

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

27599

The University of North Carolina at Chapel Hill, Chapel Hill

27710

Duke University Medical Center, Durham

28222

Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda

29425

Medical University of South Carolina, Charleston

30120

Hospital Clínico Universitario Virgen de la Arrixaca, Murcia

30214

Piedmont Heart of Fayetteville, Fayetteville

30322

Emory Heart and Vascular Center - Emory Clifton Campus, Atlanta

31059

Hôpital Rangueil, Toulouse

33331

Cleveland Clinic Florida, Weston

33604

Hôpital Haut-Lévêque, Pessac

35128

Azienda Ospedale - Università di Padova, Padua

37232

Vanderbilt University Medical Center, Nashville

40138

Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant Orsola-Malpighi, Bologna

43210

The Ohio State University College of Medicine, Columbus

44106

University Hospitals Cleveland Medical Center, Cleveland

44195

Cleveland Clinic Main Campus, Cleveland

44805

Centre Hospitalier Universitaire De Nantes - Hôpital Nord Laennec, Saint-Herblain

45219

Carl and Edyth Lindner Research Center at The Christ Hospital, Cincinnati

46202

Indiana University Health, Indianapolis

48149

Universitätsklinikum Münster, Münster

48202

Henry Ford Health System, Detroit

50139

Azienda Ospedaliero - Universitaria Careggi, Florence

50937

Uniklinik Koln, Cologne

53226

Froedtert & Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin - Madison, Madison

55407

Minneapolis Heart Institute, Minneapolis

55905

Mayo Clinic - Rochester, Rochester

56126

Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanita Pubblica, Pisa

60126

Azienda Ospedaliero Universitaria Delle Marche, Ancona

60153

Loyola University Medical Center, Maywood

60611

Northwestern University, Chicago

60637

The University of Chicago Medical Center, Chicago

63110

Barnes-Jewish Hospital, St Louis

64111

Saint Luke's Hospital of Kansas City, Kansas City

66160

University of Kansas Medical Center, Kansas City

66421

Universitätsklinikum des Saarlandes, Homburg

69120

Universitaetsklinikum Heidelberg - Zentrum fur Innere Medizin, Heidelberg

70112

Louisiana State University Health Sciences Center, New Orleans

Tulane University Heart and Vascular Institute, New Orleans

70121

Ochsner Health System, New Orleans

75390

University of Texas Southwestern Medical Center, Dallas

77030

Houston Methodist Hospital, Houston

80045

University of Colorado Hospital - Anschutz Medical Campus, Aurora

84112

University of Utah, Salt Lake City

85054

Mayo Clinic - Arizona, Phoenix

85925

Centre Hospitalier Départemental Vendée, La Roche-sur-Yon

90048

Cedars-Sinai Medical Center, Los Angeles

92037

Altman Clinical and Translational Research Institute Center for Clinical Research, La Jolla

94010

Hôpitaux Universitaires Henri Mondor, Créteil

94143

University of California, San Francisco (UCSF) - Medical Center, San Francisco

94305

Stanford Hospital, Stanford

97078

Universitätsklinikum Würzburg, Würzburg

97239

Oregon Health and Science University, Portland

98195

University of Washington, Seattle

3109601

Rambam Health Care Campus, Haifa

9112001

Hadassah University Hospital Ein Kerem, Jerusalem

13083881

Universidade Estadual de Campinas, Campinas

02114

Massachusetts General Hospital, Boston

02115

Brigham and Women's Hospital, Boston

02118

Boston University School of Medicine, Boston

C1428ART

Instituto Cardiovascular de Buenos Aires, Ciudad Autonoma de Buenos Aires

C1199ABB

Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires

NSW 2145

The Westmead Institute for Medical Research, Westmead

90560-030

Hospital Moinhos de Vento, Porto Alegre

14026-900

Centro Avançado de Pesquisa e Estudos para o Diagnóstico CAPED, Ribeirão Preto

14040-030

Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto

01323-030

A Beneficência Portuguesa de São Paulo - Unidade Mirante, São Paulo

04012-909

Instituto Dante Pazzanese de Cardiologia, São Paulo

05403-000

Instituto do Coração de São Paulo, São Paulo

T2N 4Z6

University of Calgary, Calgary

V5Z 1M9

Gordon and Leslie Diamond Health Care Centre, Vancouver

N6A 5A5

University Hospital - London Health Sciences Centre, London

M5G 2M9

Toronto General Hospital, Toronto

H2X 0C1

Centre Hospitalier de l'Université de Montréal (CHUM), Montreal

G5L 5T1

Hôpital Regional de Rimouski, Rimouski

656 91

Fakultní Nemocnice u sv. Anny v Brn, Brno

128 08

Vseobecna Fakultni Nemocnice v Praze, Prague

140 21

Institut Klinické a Experimentální Medicíny, Prague

Unknown

Kaplan Medical Center, Rehovot

00189

Azienda Ospedaliera - Universitaria Sant' Andrea, Roma

798-8510

Uwajima City Hospital, Uwajima-shi

807-8555

Hospital of the University of Occupational and Environmental Health, Kitakyushu-shi

830-0011

Kurume University Hospital, Kurume-shi

060-8543

Sapporo Medical University Hospital, Sapporo

810-0001

Saiseikai Fukuoka General Hospital, Fukuoka

802-8555

Kokura Memorial Hospital, Kitakyushu

602-8566

University Hospital Kyoto Prefectural University of Medicine, Kyoto

390-8621

Shinshu University Hospital, Matsumoto

700-8558

Okayama University Hospital, Okayama

545-8586

Osaka Metropolitan University Hospital, Osaka

431-3192

Hamamatsu University Hospital, Hamamatsu

160-8582

Keio University Hospital, Shinjuku-Ku

860-8556

Kumamoto University Hospital, Kumamoto

31-202

Krakowski Szpital Specjalistyczny im. Jana Pawa II, Krakow

04-628

Narodowy Instytut Kardiologii Stefana kardyna Wyszyskiego - Pastwowy Instytut Badawczy, Warsaw

4835-044

Hospital da Senhora da Oliveira - Guimarães, Guimarães

1169-024

Centro Hospitalar Universitário de Lisboa Central - Hospital de Santa Marta, Lisbon

4099-001

Centro Hospitalar Universitário do Porto - Hospital Geral de Santo Antonio, Porto

4200-319

Centro Hospitalar Universitário de São João, Porto

00921

Veterans Affairs Caribbean Healthcare System, San Juan

08035

Hospital Universitari Vall d'Hebrón, Barcelona

413 45

Sahlgrenska Universitetssjukhuset, Gothenburg

931 86

Skellefteå lasarett, Skellefteå

G20 0SP

Synexus - Scotland Clinical Research Centre, Glasgow

CF15 9SS

Synexus - Wales, Cardiff

B15 2SQ

Synexus Midlands Clinical Research Centre, Edgbaston

TS19 8PE

Synexus - North Tees Clinical Research Centre, Hexham

L22 0LG

Synexus - Manchester Clinical Research Centre, Liverpool

Synexus - Merseyside Clinical Research Centre, Liverpool

HR3M+6R

Royal Free London NHS Foundation Trust, London

SE1 1YR

Richmond Pharmacology, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Ionis Pharmaceuticals, Inc.

INDUSTRY