Mepolizumab as Add-on Treatment IN Participants With COPD Characterized by Frequent Exacerbations and Eosinophil Level

PHASE3CompletedINTERVENTIONAL
Enrollment

806

Participants

Timeline

Start Date

October 30, 2019

Primary Completion Date

August 8, 2024

Study Completion Date

August 8, 2024

Conditions
Pulmonary Disease, Chronic Obstructive
Interventions
BIOLOGICAL

Mepolizumab

Mepolizumab was a sterile liquid formulation. It was administered as a subcutaneous injection (100 milligrams per milliliter \[mg/mL\]) delivered once every 4 weeks using a pre-filled safety syringe.

DRUG

Placebo

Placebo was a 0.9% sodium chloride solution. It was administered as a subcutaneous injection delivered once every 4 weeks using a pre-filled safety syringe.

Trial Locations (361)

1036

GSK Investigational Site, Budapest

1051

GSK Investigational Site, Auckland

1125

GSK Investigational Site, Budapest

1646

GSK Investigational Site, Buenos Aires

2000

GSK Investigational Site, Rosario

2010

GSK Investigational Site, Sydney

2045

GSK Investigational Site, Törökbálint

2100

GSK Investigational Site, Kbenhavn N

2145

GSK Investigational Site, Westmead

2305

GSK Investigational Site, New Lambton

2400

GSK Investigational Site, Koebenhavn NV

2450

GSK Investigational Site, Coffs Harbour

3000

GSK Investigational Site, Hatvan

3010

GSK Investigational Site, Rotorua

3199

GSK Investigational Site, Frankston

3240

GSK Investigational Site, Hamilton

4000

GSK Investigational Site, San Miguel de Tucumán

GSK Investigational Site, Liège

GSK Investigational Site, Roskilde

4025

GSK Investigational Site, Debrecen

4032

GSK Investigational Site, Debrecen

4080

GSK Investigational Site, Hajdúnánás

4130

GSK Investigational Site, Havelock North

5067

GSK Investigational Site, Kent Town

5100

GSK Investigational Site, Jambes

5500

GSK Investigational Site, Mendoza

5530

GSK Investigational Site, Yvoir

5600

GSK Investigational Site, San Rafael

5700

GSK Investigational Site, Gyula

6021

GSK Investigational Site, Wellington

7100

GSK Investigational Site, Vejle

7240

GSK Investigational Site, Lobos

7600

GSK Investigational Site, Mar del Plata

7635

GSK Investigational Site, Pécs

8600

GSK Investigational Site, Siófok

8900

GSK Investigational Site, Zalaegerszeg

9100

GSK Investigational Site, Aalborg

10003

GSK Investigational Site, Cáceres

10009

GSK Investigational Site, Cadiz

10119

GSK Investigational Site, Berlin

10367

GSK Investigational Site, Berlin

10455

GSK Investigational Site, The Bronx

10717

GSK Investigational Site, Berlin

10787

GSK Investigational Site, Berlin

11490

GSK Investigational Site, Taipei

11527

GSK Investigational Site, Athens

12157

GSK Investigational Site, Berlin

12203

GSK Investigational Site, Berlin

12627

GSK Investigational Site, Berlin

15517

GSK Investigational Site, Fürstenwalde

15706

GSK Investigational Site, Santiago de Compostela

15801

GSK Investigational Site, Altoona

18014

GSK Investigational Site, Granada

18300

GSK Investigational Site, Granada

19140

GSK Investigational Site, Philadelphia

21044

GSK Investigational Site, Columbia

21431

GSK Investigational Site, Incheon

21502

GSK Investigational Site, Geesthacht

21565

GSK Investigational Site, Incheon

23552

GSK Investigational Site, Lübeck

24837

GSK Investigational Site, Schleswig

26054

GSK Investigational Site, Rio Patras

27103

GSK Investigational Site, Winston-Salem

28007

GSK Investigational Site, Madrid

28054

GSK Investigational Site, Charlotte

GSK Investigational Site, Gastonia

28150

GSK Investigational Site, Shelby

28223

GSK Investigational Site, Pozuelo de AlarcOn Madr

28401

GSK Investigational Site, Wilmington

28601

GSK Investigational Site, Hickory

29303

GSK Investigational Site, Spartanburg

29325

GSK Investigational Site, Clinton

29340

GSK Investigational Site, Greenville

29603

GSK Investigational Site, Marbella

29609

GSK Investigational Site, Brest

29615

GSK Investigational Site, Greenville

29621

GSK Investigational Site, Anderson

29630

GSK Investigational Site, Benalmádena

29707

GSK Investigational Site, Fort Mill

29732

GSK Investigational Site, Rock Hill

30000

GSK Investigational Site, Taiyuan

30046

GSK Investigational Site, Lawrenceville

30103

GSK Investigational Site, Adairsville

30189

GSK Investigational Site, Woodstock

31224

GSK Investigational Site, Peine

32117

GSK Investigational Site, Daytona Beach

32127

GSK Investigational Site, Port Orange

32608

GSK Investigational Site, Gainesville

32825

GSK Investigational Site, Orlando

33016

GSK Investigational Site, Hialeah

GSK Investigational Site, Miami Lakes

33032

GSK Investigational Site, Homestead

33126

GSK Investigational Site, Miami

33144

GSK Investigational Site, Miami

33155

GSK Investigational Site, Miami

33174

GSK Investigational Site, Miami

33186

GSK Investigational Site, Miami

33324

GSK Investigational Site, Plantation

33704

GSK Investigational Site, St. Petersburg

33765

GSK Investigational Site, Clearwater

33781

GSK Investigational Site, Pinellas Park

34295

GSK Investigational Site, Montpellier

34362

GSK Investigational Site, Haifa

34376

GSK Investigational Site, Immenhausen

34653

GSK Investigational Site, New Port Richey

35211

GSK Investigational Site, Birmingham

35501

GSK Investigational Site, Jasper

35660

GSK Investigational Site, Sheffield

36305

GSK Investigational Site, Dothan

37134

GSK Investigational Site, Verona

37909

GSK Investigational Site, Knoxville

40503

GSK Investigational Site, Lexington

40705

GSK Investigational Site, Taichung

42202

GSK Investigational Site, Częstochowa

42415

GSK Investigational Site, Daegu

43016

GSK Investigational Site, Columbus

43026

GSK Investigational Site, Hilliard

43215

GSK Investigational Site, Columbus

44009

GSK Investigational Site, Nagpur

44100

GSK Investigational Site, Guadalajara

44123

GSK Investigational Site, Ferrara

44130

GSK Investigational Site, Jalisco

44160

GSK Investigational Site, Guadalajara

44281

GSK Investigational Site, Kfar Saba

45236

GSK Investigational Site, Cincinnati

45879

GSK Investigational Site, Gelsenkirchen

46383

GSK Investigational Site, Valparaiso

46520

GSK Investigational Site, Valencia

46600

GSK Investigational Site, Alzira

47714

GSK Investigational Site, Evansville

48076

GSK Investigational Site, Lathrup Village

48431

GSK Investigational Site, Rheine

48960

GSK Investigational Site, Galdakano

49100

GSK Investigational Site, Petah Tikva

49300

GSK Investigational Site, Cholet

50009

GSK Investigational Site, Zaragoza

51080

GSK Investigational Site, Guangzhou

52621

GSK Investigational Site, Ramat Gan

54907

GSK Investigational Site, Jeonju

55131

GSK Investigational Site, Mainz

56068

GSK Investigational Site, Koblenz

57010

GSK Investigational Site, Thessaloniki

58100

GSK Investigational Site, Holon

60313

GSK Investigational Site, Frankfurt

60389

GSK Investigational Site, Frankfurt

60596

GSK Investigational Site, Frankfurt

60602

GSK Investigational Site, Chicago

63000

GSK Investigational Site, Clermont-Ferrand

63110

GSK Investigational Site, Rodgau

63141

GSK Investigational Site, St Louis

63263

GSK Investigational Site, Neu-Isenburg

64020

GSK Investigational Site, Monterrey

64460

GSK Investigational Site, Monterrey

68100

GSK Investigational Site, Mulhouse

GSK Investigational Site, Alexandroupoli

69004

GSK Investigational Site, Lyon

70020

GSK Investigational Site, Bari

70378

GSK Investigational Site, Stuttgart

72000

GSK Investigational Site, Le Mans

72032

GSK Investigational Site, Conway

73072

GSK Investigational Site, Norman

73111

GSK Investigational Site, Oklahoma City

74374

GSK Investigational Site, Epagny Metz-Tessy

75069

GSK Investigational Site, McKinney

75092

GSK Investigational Site, Sherman

75110

GSK Investigational Site, Corsicana

76100

GSK Investigational Site, Rehovot

76550

GSK Investigational Site, Lampasas

77340

GSK Investigational Site, Huntsville

77479

GSK Investigational Site, Houston

77598

GSK Investigational Site, Webster

78229

GSK Investigational Site, San Antonio

78258

GSK Investigational Site, San Antonio

78278

GSK Investigational Site, Ashkelon

78503

GSK Investigational Site, McAllen

80907

GSK Investigational Site, Colorado Springs

82037

GSK Investigational Site, Telese Terme BN

85018

GSK Investigational Site, Phoenix

85020

GSK Investigational Site, Phoenix

85050

GSK Investigational Site, Phoenix

85206

GSK Investigational Site, Mesa

85224

GSK Investigational Site, Chandler

85296

GSK Investigational Site, Gilbert

85741

GSK Investigational Site, Tucson

87108

GSK Investigational Site, Albuquerque

89014

GSK Investigational Site, Phoenix

89106

GSK Investigational Site, Las Vegas

90703

GSK Investigational Site, Cerritos

91031

GSK Investigational Site, Jerusalem

91120

GSK Investigational Site, Jerusalem

92083

GSK Investigational Site, Vista

92120

GSK Investigational Site, San Diego

92262

GSK Investigational Site, Alpine

92506

GSK Investigational Site, Riverside

92663

GSK Investigational Site, Newport Beach

97220

GSK Investigational Site, Portland

100020

GSK Investigational Site, Beijing

100029

GSK Investigational Site, Beijing

100034

GSK Investigational Site, Beijing

100730

GSK Investigational Site, Beijing

110005

GSK Investigational Site, New Delhi

110060

GSK Investigational Site, New Delhi

130021

GSK Investigational Site, Changchun

130041

GSK Investigational Site, Changchun

200032

GSK Investigational Site, Shanghai

200040

GSK Investigational Site, Shanghai

200120

GSK Investigational Site, Shanghai

201100

GSK Investigational Site, Shanghai

202002

GSK Investigational Site, Puducherry

208001

GSK Investigational Site, Kanpur

210009

GSK Investigational Site, Nanjing

210029

GSK Investigational Site, Nanjing

214023

GSK Investigational Site, Wuxi

226003

GSK Investigational Site, Lucknow

250013

GSK Investigational Site, Jinan

266071

GSK Investigational Site, Qingdao

302023

GSK Investigational Site, Jaipur

310006

GSK Investigational Site, Hangzhou

310009

GSK Investigational Site, Hangzhou

314001

GSK Investigational Site, Jiaxing

318000

GSK Investigational Site, Taizhou

330006

GSK Investigational Site, Nanchang

330038

GSK Investigational Site, Nanchang

330200

GSK Investigational Site, Nanchang

361004

GSK Investigational Site, Xiamen

380052

GSK Investigational Site, Ahmedabad

410004

GSK Investigational Site, Changsha

410005

GSK Investigational Site, Changsha

410008

GSK Investigational Site, Changsha

410013

GSK Investigational Site, Changsha

430024

GSK Investigational Site, Wuhan

440012

GSK Investigational Site, Nagpur

453000

GSK Investigational Site, Xinxiang

500003

GSK Investigational Site, Hyderabad

500018

GSK Investigational Site, Hyderabad

510080

GSK Investigational Site, Guangzhou

510150

GSK Investigational Site, Guangzhou

519001

GSK Investigational Site, Zhuhai

530021

GSK Investigational Site, Nanning

570311

GSK Investigational Site, Sanya

643036

GSK Investigational Site, Zigong

703000

GSK Investigational Site, Beer-Yaakov

810007

GSK Investigational Site, Xining

830054

GSK Investigational Site, Ürümqi

90610000

GSK Investigational Site, Porto Alegre

29720-1709

GSK Investigational Site, Chandler

90503-4818

GSK Investigational Site, Torrance

33472-2952

GSK Investigational Site, Boynton Beach

33172-1604

GSK Investigational Site, Doral

34950-4832

GSK Investigational Site, Ft. Pierce

33144-257

GSK Investigational Site, Miami

33173-3259

GSK Investigational Site, Miami

33186-6597

GSK Investigational Site, Miami

33014-2473

GSK Investigational Site, Miami Lakes

33615-3219

GSK Investigational Site, Tampa

30022-7484

GSK Investigational Site, Johns Creek

52246-2209

GSK Investigational Site, Iowa City

71457-6215

GSK Investigational Site, Natchitoches

21224-2141

GSK Investigational Site, Baltimore

08755

GSK Investigational Site, Toms River

45439-2201

GSK Investigational Site, Kettering

29406-7108

GSK Investigational Site, Charleston

75225-6301

GSK Investigational Site, Dallas

77042-4643

GSK Investigational Site, Houston

05701

GSK Investigational Site, Rutland

B1884AAC

GSK Investigational Site, Berazategui Buenos Aires

C1426ABP

GSK Investigational Site, Buenos Aires

C1425AZE

GSK Investigational Site, Ciudad AutOnoma de Buenos Aire

C1122AAK

GSK Investigational Site, Ciudad Autonoma de Bueno

C1414AIF

GSK Investigational Site, Ciudad Autonoma de Bueno

X5003DCE

GSK Investigational Site, Córdoba

B1902COS

GSK Investigational Site, La Plata

B7600DHK

GSK Investigational Site, Mar del Plata

M5500CCG

GSK Investigational Site, Mendoza

B1878FNR

GSK Investigational Site, Quilmes

S2002OJN

GSK Investigational Site, Rosario

C1121ABE

GSK Investigational Site, Rosario Provincia de Santa FE

90035-074

GSK Investigational Site, Porto Alegre

90430-000

GSK Investigational Site, Porto Alegre

05403-000

GSK Investigational Site, São Paulo

V5Z 4E1

GSK Investigational Site, Vancouver

B2N 1L2

GSK Investigational Site, Truro

L1S 2J5

GSK Investigational Site, Ajax

L3Y 5G8

GSK Investigational Site, Newmarket

N7T 4X3

GSK Investigational Site, Sarnia

N8X 1T3

GSK Investigational Site, Windsor

J6E 2B4

GSK Investigational Site, Saint-Charles-Borromée

014010

GSK Investigational Site, Baotou

010050

GSK Investigational Site, Hohehot

DK-2650

GSK Investigational Site, Hvidovre

DK-5000

GSK Investigational Site, Odense C

50-088

GSK Investigational Site, Tallinn

03050

GSK Investigational Site, Cottbus

06108

GSK Investigational Site, Halle

04103

GSK Investigational Site, Leipzig

04207

GSK Investigational Site, Leipzig

04275

GSK Investigational Site, Leipzig

04357

GSK Investigational Site, Leipzig

106 76

GSK Investigational Site, Athens

455 00

GSK Investigational Site, Ioannina

A92 VW28

GSK Investigational Site, Drogheda

D15 X40D

GSK Investigational Site, Dublin

D24 NR0A

GSK Investigational Site, Dublin

DO4T6F4

GSK Investigational Site, Dublin

H53 T971

GSK Investigational Site, Galway

V94 F858

GSK Investigational Site, Limerick

00128

GSK Investigational Site, Roma

4818 CK

GSK Investigational Site, Breda

9728 NT

GSK Investigational Site, Groningen

6419 PC

GSK Investigational Site, Heerlen

3045 PM

GSK Investigational Site, Rotterdam

2545 AA

GSK Investigational Site, The Hague

7207 AE

GSK Investigational Site, Zutphen

15-044

GSK Investigational Site, Bialystok

85-796

GSK Investigational Site, Bydgoszcz

82-300

GSK Investigational Site, Elblag

80-382

GSK Investigational Site, Gdansk

81-537

GSK Investigational Site, Gdynia

40-040

GSK Investigational Site, Katowice

40-081

GSK Investigational Site, Katowice

25-751

GSK Investigational Site, Kielce

30-033

GSK Investigational Site, Krakow

31-209

GSK Investigational Site, Krakow

90-127

GSK Investigational Site, Lodz

90-141

GSK Investigational Site, Lodz

27-400

GSK Investigational Site, Ostrowiec Świętokrzyski

60-214

GSK Investigational Site, Poznan

60-702

GSK Investigational Site, Poznan

35-051

GSK Investigational Site, Rzeszów

35-205

GSK Investigational Site, Rzeszów

81-741

GSK Investigational Site, Sopot

41-200

GSK Investigational Site, Sosnowiec

01-192

GSK Investigational Site, Warsaw

02-777

GSK Investigational Site, Warsaw

53-301

GSK Investigational Site, Wroclaw

22-400

GSK Investigational Site, Zamość

02447

GSK Investigational Site, Seoul

02559

GSK Investigational Site, Seoul

02841

GSK Investigational Site, Seoul

06591

GSK Investigational Site, Seoul

143-729

GSK Investigational Site, Seoul

08003

GSK Investigational Site, Barcelona

08017

GSK Investigational Site, Barcelona

08036

GSK Investigational Site, Barcelona

08907

GSK Investigational Site, Barcelona

08035

GSK Investigational Site, HebrOn

SE-871 31

GSK Investigational Site, Härnösand

SE-211 52

GSK Investigational Site, Malmo

SE-752 37

GSK Investigational Site, Uppsala

B15 2SQ

GSK Investigational Site, Birmingham

GSK Investigational Site, Reading

CF159SS

GSK Investigational Site, Cardiff

G20 0SP

GSK Investigational Site, Glasgow

TS19 8PE

GSK Investigational Site, Hardwick

NE46 1QJ

GSK Investigational Site, Hexham

PR7 7NA

GSK Investigational Site, Lancashire

CF15 9SS

GSK Investigational Site, Liverpool

W1G 8HU

GSK Investigational Site, London

M15 6SE

GSK Investigational Site, Manchester

NR4 7UY

GSK Investigational Site, Norwich

ML2 0DP

GSK Investigational Site, Wishaw

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

PPD Development, LP

INDUSTRY

lead

GlaxoSmithKline

INDUSTRY