TAK-788 as First-Line Treatment Versus Platinum-Based Chemotherapy for Non-Small Cell Lung Cancer (NSCLC) With EGFR Exon 20 Insertion Mutations

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

354

Participants

Timeline

Start Date

January 10, 2020

Primary Completion Date

October 31, 2026

Study Completion Date

October 31, 2026

Conditions
Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)
Interventions
DRUG

TAK-788

TAK-788 capsule

DRUG

Pemetrexed

Pemetrexed IV infusion

DRUG

Cisplatin

Cisplatin IV infusion

DRUG

Carboplatin

Carboplatin IV infusion

Trial Locations (134)

112

Taipei Veterans General Hospital, Taipei

407

Taichung Veterans General Hospital, Taichung

622

Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Dalin

640

National Taiwan University Hospital - YunLin Branch, Douliu

704

National Cheng Kung University Hospital, Tainan City

736

Chi Mei Medical Center, Liouying, Tainan City

807

Kaohsiung Medical University - Chung-Ho Memorial Hospital, Kaohsiung City

1200

Cliniques Universitaires Saint-Luc, Brussels

1210

Klinik Floridsdorf, Vienna

2065

GenesisCare North Shore, St Leonards

4102

Princess Alexandra Hospital, Woolloongabba

4200

Centro Hospitalar de Sao Joao, E.P.E., Porto

5042

Flinders Medical Centre, Bedford Park

6000

Grand Hopital de Charleroi asbl, Charleroi

9300

AZ Sint-Lucas, Aalst

10002

National Taiwan University Hospital, Taipei

10043

Azienda Sanitaria Ospedaliera S Luigi Gonzaga, Orbassano

11527

Sotiria Chest Hospital of Athens, Athens

13915

Hopital Nord AP-HM, Marseille

14004

C.H. Regional Reina Sofia - PPDS, Córdoba

14076

Centre Francois Baclesse, Caen

14165

Helios Klinikum Emil Von Behring, Berlin

15006

Hospital Universitario A Coruna, A Coruña

20133

Istituto Nazionale Dei Tumori, Milan

20141

Instituto Europeo Di Oncologia, Milan

21201

University of Maryland Greenebaum Cancer Center, Baltimore

22030

Trakya University Medical Faculty, Edirne

22908

University of Virginia Health System, Charlottesville

25006

Private Enterprise Private Manufacturing Company Acinus, Kropyvnytskyi

26121

Pius Hospital Oldenburg, Oldenburg

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz - PPDS, Madrid

28644

Chungbuk National University Hospital, Cheongju-si

31059

Hopital Larrey, Toulouse

32804

AdventHealth, Orlando

33081

Centro Di Riferimento Oncologico, Aviano

34298

CRLC Val d'Aurelle - Paul Lamarque, Montpellier

34772

T.C. Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Kadıköy

35100

Ege University Medical Faculty, Bornova

37203

Sarah Cannon Cancer Center, Nashville

38043

CHU de Grenoble, Grenoble

43126

Azienda Ospedaliero Universitaria di Parma, Parma

44000

CHU de Nantes - Hoptal Nord Laennec, Nantes

46026

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

47014

"Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST S.r.l - PPDS", Meldola

48121

Ospedale Santa Maria Delle Croci, Ravenna

49102

"Municipal Non-profit Enterprise City Clinical Hospital # 4 of Dnipro City Council - PPDS", Dnipropetrovsk

52621

Sheba Medical Center - PPDS, Ramat Gan

54290

SAKARYA University Medical Faculty, Karaman

56124

Azienda Ospedaliero Universitaria Pisana, Pisa

59037

Hopital Calmette, Lille

60596

Universitatsklinikum Frankfurt, Frankfurt am Main

60611

Northwestern University, Chicago

61070

Communal Non-profit Enterprise Regional Center of Oncology, Kharkiv

67091

Nouvel Hopital Civil, Strasbourg

69126

Thoraxklinik-Heidelberg gGmbH, Heidelberg

69373

Centre Leon Berard, Lyon

75020

Hopital Tenon, Paris

80131

AORN Dei Colli- Ospedale Monaldi Napoli, Napoli

80336

LMU Klinikum der Universitat Munchen, München

82445

E-DA hospital, Kaohsiung City

84101

Soroka University Medical Centre, Beersheba

90813

City of Hope National Medical Center, Long Beach

92868

University of California Irvine, Orange

93053

University Clinic Regensburg, Regensburg

94304

Stanford University, Palo Alto

94805

Institut Gustave Roussy, Villejuif

100142

Beijing Cancer Hospital - PPDS, Beijing

Beijing Cancer Hospital - PPDS, Beijing

101149

Beijing Chest Hospital, Capital Medical Univerity, Beijing

130012

Jilin Cancer Hospital, Changchun

150081

Harbin Medical University Tumor Hospital, Harbin

169608

National Cancer Centre, Singapore

197022

"LLC EuroCityClinic", Saint Petersburg

197758

GBUZ Saint Petersburg Clinical Research Center of Specialized Types of Care (Oncology), Saint Petersburg

200123

Shanghai East Hospital, Shanghai

310003

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

410769

National Cancer Center, Goyang

430079

Hubei Cancer Hospital, Wuhan

450008

Henan Cancer Hospital, Zhengzhou

510080

Guangdong Provincial People's Hospital, Guangzhou

610041

Sichuan Cancer Hospital & Institute, Chengdu

02115

Beth Israel Deaconess Medical Center - 330 Brookline Ave, Boston

Dana Farber Cancer Institute, Boston

Massachusetts General Hospital, Boston

V5Z-4E6

British Columbia Cancer Agency, Vancouver

L6R 3J7

William Osler Health System, Brampton

M5G2M9

Princess Margaret Hospital, Toronto

H4J 1C5

Hopital Du Sacre Coeur de Montreal, Montreal

Unknown

Icahn School of Medicine at Mount Sinai, Beijing

Princess Margaret Hospital, Kowloon City

Pamela Youde Nethersole Eastern Hospital, Hong Kong

Queen Elizabeth Hospital (QEH), Hong Kong

Queen Mary Hospital - PPDS, Hong Kong

Tuen Mun Hospital, Hong Kong

Prince of Wales Hospital, Shatin

Karolinska Universitetssjukhuset Solna, Stockholm

546 29

Bioclinic Thessaloniki (Galinos clinic), Thessaloniki

470-1101

Fujita Health University Hospital, Toyoake-Shi

277-0882

National Cancer Center Hospital East, Kashiwa-Shi

791-0280

Ehime University Hospital, Matsuyama

003-0804

National Hospital Organization Hokkaido Cancer Center, Sapporo

830-0011

Kurume University Hospital, Kurume-Shi

241-0815

Kanagawa Cancer Center, Yokohama

861-4101

Saiseikai Kumamoto Hospital, Kumamoto

981-1239

Miyagi Cancer Center, Natori-shi

700-0914

Okayama University Hospital, Okayama

540-0008

Osaka International Cancer Institute, Chuo Ku

362-0806

Saitama Cancer Center, Komoro

135-0063

The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Koto-Ku

1081 HV

VU Medisch Centrum, Amsterdam

4520-211

Centro Hospitalar do Porto Hospital de Santo Antonio, Santa Maria da Feira

4434-502

Hospital Cuf Porto, Vila Nova de Gaia

1769-001

Centro Hospitalar de Lisboa Norte E.P.E Hospital Pulido Valente, Lisbon

4200-072

Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS, Porto

602-739

Pusan National University Hospital, Busan

519-763,

Chonnam National University Hwasun Hospital, Jeongnam

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center - PPDS, Seoul

06351

Samsung Medical Center PPDS, Seoul

06591

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

120-752

Severance Hospital Yonsei University Health System - PPDS, Seoul

08907

ICO lHospitalet Hospital Duran i Reynals, L'Hospitalet de Llobregat

03010

Hospital General Universitario de Alicante, Alicante

08035

Hospital Universitario Vall d'Hebron - PPDS, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

01120

Baskent University Medical Faculty Adana Practice and Research Center, Yüreğir

06100

Hacettepe University Medical Faculty, Ankara

NW1 2PG

University College London Hospitals (UCLH), London

SM2 5PT

Royal Marsden Hospital - Surrey, Sutton

CH63 4JY

Clatterbridge Centre For Oncology, Bebington

LE1 5WW

Leicester General Hospital, Leicester

M20 4GJ

The Christie NHS Foundation Trust - PPDS, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Takeda

INDUSTRY