Efficacy and Safety of Vonoprazan Compared to Lansoprazole in Participants With Erosive Esophagitis

PHASE3CompletedINTERVENTIONAL
Enrollment

1,027

Participants

Timeline

Start Date

October 28, 2019

Primary Completion Date

July 29, 2021

Study Completion Date

August 24, 2021

Conditions
Erosive Esophagitis
Interventions
DRUG

Vonoprazan

Over-encapsulated tablet administered orally with approximately 240 mL water, 30 minutes prior to the morning meal.

DRUG

Lansoprazole

Over-encapsulated capsule administered orally with approximately 240 mL water, 30 minutes prior to the morning meal.

Trial Locations (157)

1036

Synexus (DRS) - Synexus Magyarország Kft. Budapest, Budapest

1202

Second Multiprofile Hospital for Active Treatment Sofia, Sofia

1407

Medical Center Excelsior OOD - PPDS, Sofia

1431

Diagnostic-Consultative Center Aleksandrovska EOOD, Sofia

1606

Fourth Multiprofile Hospital for Active Treatment, Sofia

1784

Synexus - Medical Center Synexus Sofia EOOD, Sofia

2700

Multiprofile Hospital for Active Treatment Puls AD - PPDS, Blagoevgrad

3000

Synexus Affiliate BKS Research Kft. Hatvan, Hatvan

4025

Synexus Affiliate - Synexus Magyarorszag Kft. Debrecen, Debrecen

4032

Debreceni Egyetem Klinikai Kozpont Nagyerdei Krt. 98, Belgyogyaszati Klinika, Debrecen

4400

Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz, Nyíregyháza

5700

Synexus (DRS) - Synexus Magyarorszag Kft. Gyula, Gyula

5800

University Multiprofile Hospital for Active Treatment, Pleven

6003

Synexus - Medical Centre Synexus Sofia EOOD, Stara Zagora

8900

Synexus (DRS) - Synexus Magyarország Kft. Zalaegerszeg, Zalaegerszeg

10530

Drug Trials America - ClinEdge, Hartsdale

14127

Southtowns Gastroenterology, PLLC, Orchard Park

20854

Meridian Clinical Research, Rockville

21286

Clinical Associates Research, Towson

22031

Verity Research, Inc., Fairfax

24073

New River Valley Research Institute, Christiansburg

24502

Blue Ridge Medical Research, Lynchburg

27262

Peters Medical Research, LLC - ClinEdge - PPDS, High Point

27408

Medication Management LLC, Greensboro

27607

Carolina's GI Research, LLC, Raleigh

27710

Duke University Medical Center, Durham

27834

Carolina Research, Greenville

28215

Carolinas Research Center, Charlotte

29406

Clinical Trials of South Carolina, Charleston

29464

Coastal Carolina Research Center, Mt. Pleasant

29621

Synexus Clinical Research US, Inc., Anderson

30071

In-Quest Medical Research, LLC, Peachtree Corners

30342

Atlanta Gastroenterology Associates, Atlanta

30345

Nexgen Research Center, Atlanta

31201

Gastroenterology Associates of Central Georgia, LLC, Macon

32132

Riverside Clinical Research, Edgewater

32256

ENCORE Borland-Groover Clinical Research - ERN - PPDS, Jacksonville

32807

Gutierrez Medical Center, Orlando

33024

Research Centers of America - ERG, Hollywood

33125

Columbus Clinical Services LLC, Miami

33134

Jesscan Medical Research, Miami

33144

Nuren Medical and Research Center, Miami

33157

Innovation Medical Research Center, Palmetto Bay

33165

Premier Research Associate, Inc., Miami

33351

Precision Clinical Research, LLC, Sunrise

33614

Guardian Angel Research Center, Tampa

33781

Synexus Clinical Research US, Inc. - St. Petersburg, Pinellas Park

34452

Nature Coast Clinical Research, Inverness

34684

Advanced Gastroenterology Associates, LLC, Palm Harbor

35211

Synexus Clinical Research US, Inc., Birmingham

35611

North Alabama Research Center LLC, Athens

35801

Medical Affiliated Research Center Inc, Huntsville

36207

Pinnacle Research Group, Anniston

37203

Clinical Research Associates Inc, Nashville

37212

Vanderbilt University Medical Center, Nashville

37601

Multi Specialty Clinical Research, Johnson City

45005

Prestige Clinical Research, Franklin

45415

Dayton Gastroenterology, Inc, Dayton

47150

Gastroenterology Health Partners, PLLC, New Albany

47714

MediSphere Medical Research Center, LLC, Evansville

48085

Oakland Medical Research Center, Troy

49519

Gastroenterology Associates of Western Michigan, PLC, Wyoming

50325

Iowa Digestive Disease Center, Clive

57701

Rapid City Medical Center LLP, Rapid City

60031

Illinois Gastroenterology Group, Gurnee

60181

Summit Digestive & Liver Disease Specialists State Street Clinic, Oakbrook Terrace

63110

Washington University School of Medicine, St Louis

64114

The Alliance for Multispecialty Research, LLC, Kansas City

68134

Heartland Clinical Research, Inc, Omaha

70006

Clinical Trials Management LLC, Metairie

70360

CroNOLA, LLC., Houma

70433

Clinical Trials Management LLC, Covington

71105

Louisiana Research Center, LLC, Shreveport

72117

Arkansas Gastroenterology, North Little Rock

Atria Clinical Research - BTC - PPDS, North Little Rock

72211

Preferred Research Partners - ClinEdge - PPDS, Little Rock

72212

Applied Research Center of Little Rock, Little Rock

73071

Central Sooner Research, Norman

75093

Synexus Clinical Research US, Inc., Plano

75234

Synexus Clinical Research US, Inc. - Dallas, Dallas

77036

Precision Research Institute, LLC, Houston

77084

Biopharma Informatic, LLC, Houston

77505

Digestive System Healthcare, Pasadena

77521

Inquest Clinical Research, Baytown

77581

Pearland Physicians, Pearland

78209

Quality Research Inc, San Antonio

78229

Gastroenterology Research of San Antonio (GERSA), San Antonio

Southern Star Research Institute, LLC, San Antonio

78503

Rio Grande Gastroenterology, McAllen

79905

Texas Tech University Health Sciences Center El Paso, El Paso

80033

Western States Clinical Research, Inc., Wheat Ridge

80909

Synexus Clinical Research US, Inc. - Colorado Springs Family Practice, Colorado Springs

84041

Synexus Clinical Research US, Inc., Layton

84405

Advanced Research Institute, Ogden

85018

Elite Clinical Studies - Phoenix - BTC - PPDS, Phoenix

Hope Research Institute LLC, Phoenix

85206

Synexus Clinical Research US, Inc. - Central Arizona Medical Associates, PC, Mesa

85213

Synexus Clinical Research US, Inc. - Desert Clinical Research, LLC, Mesa

85224

Synexus Clinical Research US, Inc. - East Valley Family Physicians, PLC, Chandler

85712

Del Sol Research Management - BTC - PPDS, Tucson

89052

Synexus Clinical Research US, Inc. Site 1, Henderson

Synexus Clinical Research US, Inc. Site 2, Henderson

89106

Sierra Clinical Research - ClinEdge - PPDS, Las Vegas

89119

Site 2, Las Vegas

89128

Las Vegas - Site 1, Las Vegas

89511

Advanced Research Institute, Reno

90033

LA County + USC Medical Center, Los Angeles

90045

Southern California Research Institute Medical Group, Inc., Los Angeles

90717

Torrance Clinical Research Institute, Lomita

91345

Facey Medical Foundation, Mission Hills

91910

GW Research, Inc. - ClinEdge - PPDS, Chula Vista

91911

eStudySite - Chula Vista - PPDS, Chula Vista

92114

Precision Research Institute, San Diego

92123

Medical Associates Research Group, Inc., San Diego

92262

Palmtree Clinical Research, Palm Springs

92703

Paragon Rx Clinical, Inc., Santa Ana

92801

Anaheim Clinical Trials LLC, Anaheim

92879

Kindred Medical Institute for Clinical Trials, LLC, Corona

93534

OM Research LLC, Lancaster

98004

Washington Gastroenterology, Bellevue

98104

Harborview Medical Center, University of Washington Medical Center, Seattle

92708-7510

HB Clinical Trials, Inc., Fountain Valley

06606

Gastroenterology Associates of Fairfield County, Bridgeport

06010

Connecticut Clinical Research Foundation, Bristol

562 18

Nemocnice Pardubickeho kraje, a.s. Orlickoustecka nemocnice, Interni oddeleni, Cs., Ústí nad Orlicí

190 00

MEDIC KRAL s.r.o., Prague

779 00

PreventaMed s.r.o., Olomouc

120 00

Synexus Czech s.r.o., Prague

401 13

Krajska zdravotni, a.s. - Masarykova nemocnice v Usti nad Labem, o.z. Oddeleni gastroenterolgie, Ústí nad Labem

85-168

Szpital Uniwersytecki Nr 2 im. Dr Jana Biziela w Bydgoszczy Centrum Endoskopii Zabiegowej - Poradnia Chorob Jelitowych, Bydgoszcz

85-681

Gabinet Lekarski-Janusz Rudzinski ul. Powstancow Warszawy 5, Bydgoszcz

42-202

Synexus - Czestochowa, Częstochowa

80-382

Synexus - Gdansk, Gdansk

81-537

Synexus - Gdynia, Gdynia

40-040

Synexus - Katowice, Katowice

31-501

Synexus Affiliate - Krakowskie Centrum Medyczne, Krakow

95-054

Centrum Opieki Zdrowotnej Orkan-Med Stec-Michalska Sp. J., Ksawerów

90-127

Synexus - Lodz, Lodz

90-302

Santa Familia Centrum Badań Profilaktyki i Leczenia, Lodz

20-582

GASTRO MED Zaklad Opieki Zdrowotnej, Lublin

60-702

Synexus - Poznan, Poznan

35-302

Korczowski Bartosz, Gabinet Lekarski, Rzeszów

71-434

Twoja Przychodnia - Szczecińskie Centrum Medyczne, Szczecin

87-100

Gastromed Specjalistyczne Centrum Gastrologii i Endoskopii, Torun

0-691

REUMATIKA - Centrum Reumatologii NZOZ, Warsaw

01-192

Synexus - Warszawa, Warsaw

50-381

Synexus - Wroclaw, Wroclaw

50-449

Melita Medical, Wroclaw

RG2 0TG

Synexus Thames Valley Clinical Research Centre, Reading

B15 2SQ

Synexus - Midlands Clinical Research Centre, Edgbaston

CF15 9SS

Synexus - Wales Clinical Research Centre, Cardiff

PR7 7NA

Synexus - Lancashire Clinical Research Centre, Chorley

G20 0XA

CPS Research, Glasgow

NE46 1QJ

Synexus - Hexham Clinical Research Centre, Hexham

L22 0LG

Synexus - Merseyside Clinical Research Centre, Liverpool

M15 6SE

Synexus - Manchester Clinical Research Centre, Manchester

TS19 8PE

Synexus - North Tees Clinical Research Centre, Stockton-on-Tees

Sponsors
All Listed Sponsors
lead

Phathom Pharmaceuticals, Inc.

INDUSTRY