ASTRAL- a Clinical Study to Assess the Efficacy and Toxicity of High-dose Chemotherapy

PHASE2CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

June 24, 2019

Primary Completion Date

March 30, 2022

Study Completion Date

February 2, 2023

Conditions
Aggressive Non-hodgkin Lymphoma (aNHL)Lymphoma, B-CellLymphoma, T-Cell
Interventions
DRUG

High dose chemotherapy before allogeneic stem cell transplantation (alloSCT)

High-dose therapy (HDT) prior to alloSCT will consist of FTC

PROCEDURE

Bone marrow histology

Bone marrow histology at staging and restaging is only mandatory if the bone marrow was initially involved

DIAGNOSTIC_TEST

clinical and laboratory parameters

During staging and restaging examinations, all clinical and laboratory parameters relevant for therapy.

DIAGNOSTIC_TEST

PET-CT or CT

Metabolic CR in a PET-CT scan after the last cycle of therapy prior to planned SCT. Consists preferably of a PET-CT or a CT scan according to local practice and other appropriate diagnostic procedures with respect to the sites of primary involvement.

Trial Locations (13)

13125

HELIOS Klinik Berlin-Buch, Klinik für Hämatologie und Stammzelltransplantation, Berlin

20246

Universitätsklinikum Hamburg-Eppendorf, Zentrum für Onkologie, Interdisziplinäre Klinik und Poliklinik für Stammzelltransplantation, Hamburg

37075

Universitätsmedizin Göttingen Klinik für Hämatologie/Med. Onkologie, Göttingen

40225

Universitäsklinikum Düsseldorf, Düsseldorf

44892

Medizinisches Universitätsklinikum, Bochum

48149

Universitätsklinikum Münster, KMT-Zentrum/ Med. Klinik A, Münster

69120

Universitätsklinikum Heidelberg, Medizinische Klinik, Innere Medizin V, Heidelberg

70174

Klinikum Stuttgart, Stuttgart

Unknown

Klinikum Augsburg, Medizinische Klinik II, Augsburg

Universitätsklinikum Carl Gustav Carus Dresden, Medzinische Klinik I, Dresden

09116

Klinikum Chemnitz gGmbH, Chemnitz

06120

Universitätsklinikum Halle, Halle

07747

Universitätsklinikum Jena, Klinik für Innere Medizin, Abtl. Hämatologie und Innternistische Onkologie, Jena

All Listed Sponsors
lead

GWT-TUD GmbH

OTHER

NCT04121507 - ASTRAL- a Clinical Study to Assess the Efficacy and Toxicity of High-dose Chemotherapy | Biotech Hunter | Biotech Hunter